ABSTRACT
Background: Radical cystectomy and removal of pelvic lymph nodes (RC-PLND) is a recommended treatment for high-risk non-muscle-invasive and muscle-invasive non-metastatic bladder cancer (BC). However, 50% of patients relapse after RC-PLND. This study aimed to evaluate the effect of programmed cell death ligand-1 (PD-L1) on the prognosis of bladder urothelial carcinoma (BUC) after RC-PLND. Methods: We present this meta-analysis according to the Preferred Reporting Items for Systematic Review and Meta-Analyses Guidelines. The main outcomes were overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival (CSS) of 3 and 5 years after RC-PLND. Results: Overall, 11 studies and 1393 BUC cases were included in our meta-analysis. In tumor cells (TCs), the PD-L1 negative group had statistically significant advantage in 5-year OS (risk ratio [RR]: 0.85, 95% confidence interval [CI]: 0.74-0.97, P = 0.02), RFS (RR: 0.76, 95% CI: 0.58-0.99, P = 0.04), and CSS (RR: 0.73, 95% CI: 0.58-0.92, P = 0.009) compared with the PD-L1 positive group. But, no statistically significant difference in 5-year OS and RFS was observed between the PD-L1 negative and positive groups in tumor-infiltrating immune cells. Conclusions: Our study found that patients with BUC who tested positive for PD-L1 in TCs had a poor prognosis after RC-PLND. PD-1 or PD-L1 inhibitors could be used as a adjuvant medication for patients with BUC after RC-PLND who exhibit PD-L1 overexpression in TCs. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42022301424.
Subject(s)
Carcinoma, Transitional Cell , Urinary Bladder Neoplasms , Apoptosis , B7-H1 Antigen/genetics , B7-H1 Antigen/metabolism , Carcinoma, Transitional Cell/pathology , Cystectomy , Humans , Immune Checkpoint Inhibitors , Ligands , Lymph Node Excision , Neoplasm Recurrence, Local/pathology , Prognosis , Programmed Cell Death 1 Receptor , Urinary Bladder , Urinary Bladder Neoplasms/pathologyABSTRACT
A new species of the peltoperlid genus Microperla Chu, 1928, Microperla qinlinga Chen, sp. nov. from Shaanxi Province of northwestern China is described and illustrated. The new species is characterized by the widely rounded ventral lobe in males and the extremely large and bilobed subgenital plate in female. In addition, the taxonomic history and current status of the genus Microperla is reviewed.
Subject(s)
Insecta , Animal Distribution , Animals , China , Female , Male , NeopteraABSTRACT
A new species of the perlodid genus Isoperla Banks, 1906, Isoperla qinlinga Chen, sp. nov. from Shaanxi Province of northwestern China is described. The new species is characterized by the mostly dark head and pronotum, the poorly developed vesicle, the modified ventral and dorsal aedeagal lobes, and the slightly developed, rounded subgenital plate of the female. Comments are provided on the known species of Isoperla of China.
Subject(s)
Insecta , Animals , China , Female , NeopteraABSTRACT
A new winter stonefly species of the genus Capnia Pictet, 1841, Capnia s.l. bilobata sp. nov. is described and illustrated from Shaanxi Province of northwestern China. The new species is distinguished from all currently known Capnia s.l. by the male and female genitalic characters. The falciform projection on male tergum 9 and the unique-shaped female subgenital plate separate the new taxon from other congeners.
