N'-(2-Hy-droxy-1,2-diphenyl-ethyl-idene)benzohydrazide.

In the title compound, C(21)H(18)N(2)O(2), the amino group is involved in an intra-molecular N-H⋯O hydrogen bond. The rings make dihedral angles of 37.9 (2), 64.4 (2) and 83.6 (2)°. In the crystal, inter-molecular O-H⋯N and O-H⋯O hydrogen bonds link the mol-ecules into chains running along [100].

N,N-Bis(pyridin-2-yl-methyl-idene)pyridine-2,6-dicarbohydrazide dimethyl-formamide monosolvate.

In the crystal of the title compound, C(22)H(22)N(8)O(3), the dicarbohydrazide mol-ecules are linked into a chain along [010] by C-H⋯N inter-actions involving the pyridyl N atoms and aromatic C-H groups. The DMF mol-ecule is hydrogen bonded with the amide N-H via N-H⋯O inter-actions. C-H⋯O inter-actions also occur.

1-(2-Hy-droxy-benzo-yl)thio-semicarbazide hemihydrate.

The asymmetric unit of the title compound, C(8)H(9)N(3)O(2)S·0.5H(2)O, contains two thiosemicarbazide mol-ecules with the short distance of 3.521 (3) Šbetween the centroids of the benzene rings, and one water mol-ecule. In the two independent mol-ecules, the benzene rings and the thio-semicarbazone fragments are twisted at 9.2 (3) and 18.5 (3)°. An extensive three-dimensional hydrogen-bonding network, formed by inter-molecular N-H⋯O, N-H⋯S and O-H⋯O hydrogen bonds, consolidates the crystal packing.

N'-(2-Chloro-benzyl-idene)benzo-hydrazide.

The asymmetric unit of the title compound, C(14)H(11)ClN(2)O, contains two independent mol-ecules. In one mol-ecule, the two aromatic rings form a dihedral angle of 45.94 (16)°, while in the second mol-ecule this angle is 58.48 (16)°. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into two crystallographically independent sets of chains propagating along [001].

(E)-N'-[1-(4-Bromo-phen-yl)ethyl-idene]-2-hydroxy-benzohydrazide.

In the title compound, C(15)H(13)BrN(2)O(2), the two aromatic rings form a dihedral angle of 7.9 (1)° and an intra-molecular N-H⋯O hydrogen bond influences the mol-ecular conformation. In the crystal, inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into chains propagated in [001]. The crystal packing exhibits also π-π inter-actions, which pair mol-ecules into centrosymmetric dimers with short inter-molecular distances of 3.671 (4) Šbetween the centroids of aromatic rings.

(E)-N'-(2-Furylmethyl-ene)benzo-hydrazide.

In the title compound, C(12)H(10)N(2)O(2), the dihedral angle between the benzene and furan rings is 52.54 (7)°. In the crystal, inter-molecular N-H⋯O hydrogen bonds and C-H⋯π inter-actions link the mol-ecules.

(E)-N'-(4-Methoxy-benzyl-idene)benzohydrazide.

In the title mol-ecule, C(15)H(14)N(2)O(2), the dihedral angle between the benzene rings is 5.93 (17)°. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into chains propagating in [010].

Microcalorimetric study on host-guest complexation of naphtho-15-crown-5 with four ions of alkaline earth metal.

Thermodynamic parameters of complexation of naphto-15-crown-5 with four alkaline earth ions in aqueous media was determined using titration microcalorimetry at 298.15 K. The stability of the complexes, thermal effect and entropy effect of the complexation is discussed on the basis of the guest ions structure and the solvent effect. The stability constants tendency to vary with ion radius was interpreted. Complex of naphtha-15-crown-5 with calcium ion is very stable due to the synergism of static electric interaction and size selectivity between the host and the guest.

[Clinical evaluation of integration of transcatheter arterial chemoembolization and traditional Chinese medicine in treating metastatic liver cancer].

OBJECTIVE: To evaluate the treatment effect, quality of life and side-effect of transcatheter arterial chemoembolization (TACE) and traditional Chinese medicine (TCM) in treating metastatic liver cancer. METHODS: Thirty-nine cases of colon metastatic liver cancer were randomly divided into two groups. Both TACE and TCM were used in the treatment group, while only TACE was used in the control group. The drug used in TACE included floxuridine, pirarubicin, cisplatin, and the herbs for strengthening the spleen and regulating Qi were used in TCM. RESULTS: The response rate in the treatment group was 30% (45% including minor remission patients), and the median survival time was 18.6 months. While in the control group the response rate was 15.8% (36.8% including minor remission patients), and the median survival time was 14.3 months. The 1-, 2-, 3- year survival rates of treatment group and the control group were 70.2%, 40.3%, 13.0% and 68.7%, 29.5%, 10.3% respectively. There were fewer other organ metastases in the treatment group. The score from the EORTC quality of life questionnaire QLQ-C30 in treatment group was higher than that in the control group. CONCLUSION: Integration of TACE and TCM in treating colon metastatic liver cancer has better results.

[Evaluation of therapeutic effects of traditional Chinese medicine combined with western medicine on breast cancer after resection: analysis of 71 cases].

OBJECTIVE: To evaluate the effectiveness of traditional Chinese medicine (TCM) combined with western medicine on breast cancer after surgical resection. METHODS: Seventy-one patients with breast cancer received chemotherapy, radiotherapy, endocrine therapy and TCM following resection. RESULTS: None of the patients died during the follow-up period. Fifty-seven patients were treated with TCM shortly after undergoing resection. Two recurrences (3.5%) and 6 metastases (10.5%) were observed in 8 patients, whose median disease free survival was 5.9 years. Fourteen patients didn't receive TCM until recurrence or metastasis emerged, with a median disease free survival of 3.5 years. There was significant difference between the two groups (P=0.033). CONCLUSION: TCM combined with western medicine is efficient in preventing and delaying recurrence and metastasis.