ABSTRACT
OBJECTIVES: We explored whether newly developed application (Smartphone-based brain Anti-aging and memory Reinforcement Training, SMART) improved memory performance in older adults with subjective memory complaints (SMC). METHOD: A total of 53 adults (range: 50-68 years; 52.8% female) were randomized into either one of two intervention groups [SMART (n = 18) vs. Fit Brains® (n = 19)] or a wait-list group (n = 16). Participants in the intervention groups underwent 15-20 minutes of training per day, five days per week for 8 weeks. We used objective cognitive measures to evaluate changes with respect to four domains: attention, memory, working memory (WM), and response inhibition. In addition, we included self-report questionnaires to assess levels of SMC, depression, and anxiety. RESULTS: Total WM quotient [t(17) = 6.27, p < .001] as well as auditory-verbal WM score [t(17) = 4.45, p < .001] increased significantly in the SMART group but not in the control groups. Self-reports of memory contentment, however, increased in the Fit Brains® group only [t(18) = 2.12, p < .05). CONCLUSION: Use of an 8-week smartphone-based memory training program may improve WM function in older adults. However, objective improvement in performance does not necessarily lead to decreased SMC.
Subject(s)
Cognitive Remediation/methods , Memory Disorders/rehabilitation , Memory, Short-Term , Mobile Applications , Aged , Diagnostic Self Evaluation , Female , Humans , Male , Middle Aged , Smartphone , Treatment OutcomeABSTRACT
Patients with schizophrenia present with dysfunction of the magnocellular pathway, which might impair their early visual processing. We explored the relationship between functional abnormality of early visual processing and brain volumetric changes in schizophrenia. Eighteen patients and 16 healthy controls underwent electroencephalographic recordings and high-resolution magnetic resonance imaging. During electroencephalographic recordings, participants passively viewed neutral or fearful faces with broad, high, or low spatial frequency characteristics. Voxel-based morphometry was performed to investigate brain volume correlates of visual processing deficits. Event related potential analysis suggested that patients with schizophrenia had relatively impaired P100 processing of low spatial frequency fearful face stimuli compared with healthy controls; patients' gray-matter volumes in the dorsolateral and medial prefrontal cortices positively correlated with this amplitude. In addition, patients' gray-matter volume in the right cuneus positively correlated with the P100 amplitude in the left hemisphere for the high spatial frequency neutral face condition and that in the left dorsolateral prefrontal cortex negatively correlated with the negative score of the Positive and Negative Syndrome Scale. No significant correlations were observed in healthy controls. This study suggests that the cuneus and prefrontal cortex are significantly involved with the early visual processing of magnocellular input in patients with schizophrenia.
ABSTRACT
Previous meta-analytic studies conducted in Western countries have consistently revealed impairments in theory of mind (ToM) in schizophrenia. However, there is no systematic meta-analytic review of ToM deficits in individuals with schizophrenia in non-Western countries. In addition, ToM impairments in individuals with schizophrenia have not been investigated in the distinctive domains (i.e., verbal vs. visual, or affective vs. cognitive). The current meta-analytic study systematically synthesized 13 studies comparing ToM performance of adults with schizophrenia (n=377) and that of healthy controls (n=386) in Korea. The results indicate that Koreans with schizophrenia showed overall large ToM impairments (d=-1.273) but intact performance in control tasks that require a similar amount of cognitive demand as ToM tasks do. Large impairments in affective and cognitive ToM (d=-1.445 and -1.202, respectively) and verbal and visual ToM (d=-1.239 and -1.221, respectively) were found in Koreans with schizophrenia. There were no differences in magnitude between affective and cognitive ToM or between verbal and visual ToM. These results suggest that Koreans with schizophrenia experience substantial impairments in various ToM domains. Comprehensive multi-modality-based assessment targeting various ToM domains should be considered for treatment planning of individuals with schizophrenia.
Subject(s)
Schizophrenia , Schizophrenic Psychology , Theory of Mind , Adult , Female , Humans , Male , Republic of Korea , Schizophrenia/ethnologyABSTRACT
Abnormal facial emotion recognition is considered as one of the key symptoms of schizophrenia. Only few studies have considered deficits in the spatial frequency (SF)-dependent visual pathway leading to abnormal facial emotion recognition in schizophrenia. Twenty-one patients with schizophrenia and 19 matched healthy controls (HC) were recruited for this study. Event-related potentials (ERP) were measured during presentation of SF-modulated face stimuli and their source imaging was analyzed. The patients showed reduced P100 amplitude for low-spatial frequency (LSF) pictures of fearful faces compared with the HC group. The P100 amplitude for high-spatial frequency (HSF) pictures of neutral faces was increased in the schizophrenia group, but not in the HC group. The neural source activities of the LSF fearful faces and HSF neutral faces led to hypo- and hyperactivation of the frontal lobe of subjects from the schizophrenia group and HC group, respectively. In addition, patients with schizophrenia showed enhanced N170 activation in the right hemisphere in the LSF condition, while the HC group did not. Our results suggest that deficits in the LSF-dependent visual pathway, which involves magnocellular neurons, impair early visual processing leading to dysfunctional facial emotion recognition in schizophrenia. Moreover, it suggests impaired bottom-up processing rather than top-down dysfunction for facial emotion recognition in these patients.
