1.
Chem Commun (Camb)
; 52(72): 10886-9, 2016 Sep 18.
Article
in English
| MEDLINE
| ID: mdl-27530357
ABSTRACT
We have designed and synthesized MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential self-adjuvanting cancer vaccines using a linear solid phase peptide synthesis strategy. These vaccine candidates have elicited T cell dependent immune response and the induced antibodies showed intense specific binding affinity to human MCF-7 cells.
Subject(s)
Bacterial Proteins/chemistry , Cancer Vaccines/chemistry , Lymphokines/chemistry , Mucin-1/chemistry , Adjuvants, Immunologic , Amino Acid Sequence , Animals , Antibodies/immunology , Antibodies/metabolism , Bacterial Proteins/immunology , Cancer Vaccines/chemical synthesis , Cancer Vaccines/immunology , Cytokines/analysis , Cytokines/metabolism , Enzyme-Linked Immunosorbent Assay , Humans , Lymphokines/immunology , MCF-7 Cells , Mice , Mucin-1/immunology , Mycoplasma salivarium/metabolism , Neoplasms/immunology , Neoplasms/pathology , Neoplasms/prevention & control , Solid-Phase Synthesis Techniques , T-Lymphocytes/cytology , T-Lymphocytes/immunology , T-Lymphocytes/metabolism
2.
Org Biomol Chem
; 12(37): 7310-7, 2014 Oct 07.
Article
in English
| MEDLINE
| ID: mdl-25113599
ABSTRACT
A concise synthesis of (2S,5R) and (2S,5S)-5-hydroxy-lysine was achieved by utilizing D-galactose as a chiral-precursor with stereo retention. This synthetic strategy showcased the potential of utilizing carbohydrates as starting materials to prepare amino acids. Using the diazido intermediate, the derived ß-D-galactopyranosyl and α-D-glucopyranosyl-(1â2)-ß-D-galactosyl moieties were synthesized.
