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1.
Food Chem Toxicol ; 179: 113982, 2023 Sep.
Article in English | MEDLINE | ID: mdl-37553049

ABSTRACT

The presence of anorexia in animals is the most well-known clinical symptom of T-2 toxin poisoning. T-2 toxin is the most characteristic type A toxin in the trichothecene mycotoxins. The consumption of T-2 toxin can cause anorexic response in mice, rats, rabbits, and other animals. In this review, the basic information of T-2 toxin, appetite regulation mechanism and the molecular mechanism of T-2 toxin-induced anorectic response in animals are presented and discussed. The objective of this overview is to describe the research progress of anorexia in animals produced by T-2 toxin. T-2 toxin mainly causes antifeedant reaction through four pathways: vagus nerve, gastrointestinal hormone, neurotransmitter and cytokine. This review aims to give an academic basis and useable reference for the prevention and treatment of clinical symptoms of anorexia in animals resulting from T-2 toxin.


Subject(s)
Appetite Depressants , Mycotoxins , T-2 Toxin , Mice , Rats , Animals , Rabbits , Anorexia/chemically induced , Mycotoxins/adverse effects , Neurotransmitter Agents
2.
Zhonghua Yan Ke Za Zhi ; 39(12): 710-3, 2003 Dec.
Article in Chinese | MEDLINE | ID: mdl-14769219

ABSTRACT

OBJECTIVE: Human visual plasticity was studied by the observation of the effects of treatment in teenage and adult amblyopia. METHODS: One hundred and two cases (125 eyes) were diagnosed as amblyopia according to the national criteria of amblyopia. These patients were divided into teenage group (15 - 17 years old, 47 cases and 57 eyes) and adult group (18 - 45 years old, 55 cases and 68 eyes). Eye examination, including best correct visual acuity, laser interference fringes visual acuity (IVA), degree and patterns of amblyopia, and nature of fixation were performed in these two groups before amblyopic treatment. Patients were treated with correct spectacle, optical and drug penalization (including far and near penalization, as well as light penalization), combined with occlusion and assisted with red light pleoption. All patients were followed up for 1 - 5 years, with an average of 2.9 years. RESULTS: Fifty five eyes (44%) were cured (23 eyes recovered, 32 eyes basically cured), 37 eyes (29.6%) were improved, 33 eyes (26.4%) were nullified and the total improvement rate was 73.6%. Different ages did not influence the results of treatment significantly (P > 0.05). Outcome of foveal fixation and parafoveal fixation was much better than that of paramacular fixation and peripheral fixation (P < 0.005). The curative efficiency of amblyopia was also dependent on the degree of amblyopia (P < 0.005). Curative effects of ametropic and anisometropic amblyopia were better than that of strabismic and deprivable amblyopia (P < 0.01). Visual acuity predicted by IVA before the treatment was the same as real results after the treatment in 112 eyes among 125 eyes (92.8%). The correlation efficient between the predicted and real vision was statistically significant (r = 0.886 2, P < 0.000 1). CONCLUSIONS: Vision in most teenage and adult amblyopia can be improved by amblyopic therapy. Therefore, it seems that human visual plasticity exists permanently during the whole life. Visual acuity after the treatment can be predicted by pre-treatment IVA. Results of amblyopia treatment are closely related with the degree and patterns of amblyopia and are also dependent on the cooperation of the patients.


Subject(s)
Amblyopia/therapy , Vision, Ocular , Adolescent , Adult , Age Factors , Amblyopia/physiopathology , Female , Humans , Male , Middle Aged , Visual Acuity
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