ABSTRACT
Voxel-based morphometry (VBM) studies have provided cumulative evidence of gray matter (GM) atrophy in patients with progressive supranuclear palsy (PSP) relative to healthy controls (HC). However, not all findings have been entirely concordant. Herein, we performed a quantitative meta-analysis study in order to consistently quantify GM anomalies in PSP. We conducted a systematic search for VBM studies of PSP patients and HC using PubMed and Embase databases from January 2000 to May 2012. Meta-analysis of these VBM studies was performed using a newly improved voxel-based meta-analytic technique, effect-size signed differential mapping. A total of 9 cross-sectional VBM studies that involved 143 PSP patients and 216 HC subjects met the inclusion criteria. Considerable regional GM volume decrease was detected in the thalamus, basal ganglia, midbrain, insular cortex, and frontal cortex. These findings remained largely unchanged following jackknife sensitivity analyses. The present meta-analysis provided evidence of PSP-specific GM atrophy. This finding might help contribute to our understanding of the neurobiological basis underlying PSP.
Subject(s)
Brain Mapping/methods , Cerebral Cortex/pathology , Supranuclear Palsy, Progressive/pathology , Animals , Atrophy/diagnosis , Atrophy/epidemiology , Clinical Trials as Topic/methods , Humans , Supranuclear Palsy, Progressive/diagnosis , Supranuclear Palsy, Progressive/epidemiologyABSTRACT
Voxel-based morphometry (VBM) studies have provided cumulative evidence of gray matter (GM) atrophy in patients with Parkinson's disease with dementia (PDD) relative to healthy controls (HC). However, not all the studies reported entirely consistent findings. A systematic search for VBM studies of PDD patients and HC subjects published in PubMed and Embase databases from January 2000 to June 2012 was conducted. Meta-analysis was performed by using a newly improved voxel-based meta-analytic technique, effect size signed differential mapping, to quantitatively explore the GM abnormalities between PDD patients and HC subjects. A total of 6 cross-sectional VBM studies involving 105 PDD patients and 131 HC subjects met the inclusion criteria. Considerable regional GM decrease was detected in the medial temporal lobe (MTL) and basal ganglia. The findings of the present study remained largely unchanged in the entire brain jackknife sensitivity analyses. Meta-regression showed dementia severity correlated with the left MTL. The present meta-analysis provided evidence of PDD-related GM atrophy, which suggested MTL and basal ganglia were implicated in PDD. This finding could give us further insight about the pathophysiological basis revealed by structure abnormalities in PDD.
Subject(s)
Brain/pathology , Dementia/pathology , Parkinson Disease/pathology , Aged , Aged, 80 and over , Atrophy/etiology , Atrophy/pathology , Brain Mapping , Databases, Bibliographic/statistics & numerical data , Dementia/complications , Female , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Mental Status Schedule , Parkinson Disease/complicationsABSTRACT
OBJECTIVE: To study the effect of some active Chinese herbal fraction on protein expression of brain tissue in ischemic mouse with proteomic technique. METHODS: Ischemia-reperfusion mice were treated with baicalin, geniposide, cholic acid and concha margaritifera respectively for 3 hrs, and then their brain tissue were taken to extract the total protein. Protein expression in ischemic mouse brain was analyzed with surface-enhanced laser desorption/inionation-time of flight-mass spectra (SELDI-TOF-MS) protein-chip. RESULTS: The four components tested had effect on 3 target proteins at 5373Da, 5707Da and 15103Da, showing the nature of multi-target and with different action on protein expression. CONCLUSION: Protein-chip is an effective approach for exploring the pharmacological mechanism of Chinese herbal fraction.
