ABSTRACT
BACKGROUND: Deep Sylvian meningiomas are rare and difficult to diagnose when small tumours lead to various symptoms. The difficulty associated with surgery is underestimated. Our case involved a mass (11 mm × 12 mm × 12 mm in size) in the right Sylvian fissure. It is the smallest deep Sylvian meningioma known and might be more easily misdiagnosed than previous examples. CASE SUMMARY: A well-enhanced mass in the right Sylvian fissure of a 26-year-old male with a three-month history of seizure was identified via magnetic resonance imaging. The patient underwent operations twice for seizure control. During the first operation, the tumour was surrounded by the second segment of the middle cerebral artery and its numerous perforators. Partial resection had to be selected due to mild arterial damage. After the first operation, the patient presented with simple partial seizure. During reoperation, we isolated the anatomical structure near the tumour and the tumour over and removed it from its dorsal side by piecemeal resection. CONCLUSION: This case reported the smallest deep Sylvian meningioma according to a literature review. Preoperative diagnosis is a crucial step due to deep Sylvian meningioma firmly adhering to the middle cerebral artery and its perforators. Adequate preparation is crucial to ensure the success of surgery.
ABSTRACT
OBJECTIVE: To explore the expression of δ subunit-containing γ-aminobutyric acid(A) (GABA)(A) receptors in insular electrical kindled rats and analyze the significance of the findings. METHODS: A total of 48 male Sprague-Dawley rats were divided randomly into 3 groups: kindled, sham-operated and control. Kindled group: chronic insular electrical kindled models of rats established by electrical stimulation. Sham-operated group: the same method of the kindled group without electrical stimulation. CONTROL GROUP: without surgery. The number of hippocampal neurons of rat epilepsy, sham-operated and control groups were detected by Nissl staining. The hippocampal expressions of δ subunit of these groups were tested by immunohistochemistry. The mRNA of δ subunit of hippocampus of these groups was detected by quantitative-polymerase chain reaction (q-PCR). RESULTS: The findings of Nissl staining showed that there was no significant difference of the number of hippocampal neurons between epileptic and normal rats (P > 0.05). The findings of q-PCR showed that mRNA of δ subunit of the hippocampus of sham-operated and control groups represented much more than that of kindled group at Day 7 post-kindling (P < 0.01). The findings of immunohistochemistry showed that the hippocampal expression of δ subunit of sham-operated and control groups represented much more than that of kindled group at Day 7 post-kindling (P < 0.01). CONCLUSION: The hippocampal expression of δ subunit-containing GABA(A) receptors decreases in insular epilepsy. It may play an important role in the occurrence and development of insular epilepsy.
