[The feasibility of using Quick Dementia Rating System in clinical practice: results of a multi-center prospective validation study]. / Vozmozhnost' ispol'zovaniia shkaly bystroi otsenki dementsii v klinicheskoi praktike: rezul'taty mnogotsentrovogo prospektivnogo issledovaniia.

AIM: To determine the sensitivity and specificity of the Quick Dementia Rating System (QDRS), a 10-item questionnaire for the assessment of cognitive, behavioral, and functional impairments, in the Russian population. MATERIAL AND METHODS: The authors examined 2357 patients,1479 female (63%) and 878 male (37%), with subjective cognitive impairment (SCI), mild cognitive impairment (MCI) or dementia. Their average age was 73,1±9,7. All patients were assessed using QDRS and MMSE on baseline visits and reassessed after 1, 3, and 6 months. RESULTS: The sensitivity and specificity of QDRS were 79,2% and 81,2%, respectively, at cut-interval of more than 7 points. There was a strong inverse correlation between QDRS and MMSE indicators (r=-0,740). QDRS was the most sensitive for the detection of severe dementia (sensitivity of 78,2% and specificity of 85,2%), while for mild and moderate dementia the sensitivity was high (79,4% and 81,6%) and specificity was low (56,6% and 61,9%, respectively). The sensitivity and specificity of separate subtests were variable. CONCLUSION: The QDRS sensitivity and specificity allow recommending it for clinical practice. The questionnaire is the most sensitive to detect more severe cognitive impairment.

[Modern trends in epidemiology of dementia and management of patients with cognitive impairment]. / Sovremennye tendentsii v épidemiologii dementsii i vedenii patsientov s kognitivnymi narusheniiami.

Dementia is an important medical problem with the prevalence and significance growing year after year. Improvement of diagnostic methods facilitates early diagnosis and treatment. This year marks the 20th anniversary of memantine, one of the basic anti-dementia drugs, registration in Russia. It provided conditions for more efficient care of patients with dementia and development of memory clinics in Moscow and major regions of Russia used modern investigation technology and neuropsychological testing. Many multi-central studies involving 1250 patients with cognitive impairment were conducted A great number of educational activities, social projects that helped to increase awareness of dementia issues in medical community as well as society in general were implemented. Total screening programs for identification of cognitive impairment are being introduced, psychological support programs for caregivers of dementia patients are being implemented.