ABSTRACT
Rectal administration of metaside (20 mg per 100 g body weight) as suppositories for 10 days was found to cause vitamin B2 deficiency both in rats on low-vitamin B2 diet and in those on balanced diet. This appeared as decreased vitamin B2 levels in the liver and plasma. The design and application of suppositories containing the mixed preparation of metaside and riboflavin drug (in a dose of 100 micrograms per rat, which corresponds to the recommended daily requirement) completely prevents vitamin B2 deficiency.
Subject(s)
Antitubercular Agents/pharmacology , Isoniazid/analogs & derivatives , Riboflavin Deficiency/chemically induced , Riboflavin Deficiency/prevention & control , Animals , Antitubercular Agents/administration & dosage , Drug Combinations , Drug Evaluation, Preclinical , Isoniazid/administration & dosage , Isoniazid/pharmacology , Liver/drug effects , Liver/metabolism , Rats , Riboflavin/administration & dosage , Riboflavin/metabolism , Riboflavin/pharmacology , Riboflavin Deficiency/metabolism , SuppositoriesABSTRACT
It was established that 10-day administration of suppository methazide (20 mg per 100 g b. w.) induces B2 vitamin deficiency indicated by relevant hepatic and plasmic values. In vitamin B2 deficiency methazide-induced changes in vitamin B6 metabolism are less marked in rats provided with riboflavin. Use of suppository methazide in combination with riboflavin (100 micrograms per animal which is a recommended daily dose) prevents B2 deficiency. It is recommended daily use combinations of methazide with riboflavin or piridoxin in essential daily consumption doses to treat patients with alimentary vitamin B2 and B6 deficiencies. This will not only prevent side effects of methazide, but also help to overcome deficiency of the above vitamins.
Subject(s)
Isoniazid/analogs & derivatives , Pyridoxine/administration & dosage , Riboflavin/administration & dosage , Vitamin B Complex/metabolism , Animals , Drug Combinations , Drug Evaluation, Preclinical , Isoniazid/administration & dosage , Isoniazid/adverse effects , Rats , Riboflavin Deficiency/drug therapy , Riboflavin Deficiency/metabolism , Suppositories , Vitamin B 6 Deficiency/drug therapy , Vitamin B 6 Deficiency/metabolism , Vitamin B Complex/analysisABSTRACT
Experiments on 220 chick embryos were made to study the embryotoxic action of ethyl alcohol and nicotine administered alone and combined, depending on the drug dose, route and frequency of administration. It has been disclosed that the toxic effect of the drugs manifests primarily at the cellular and subcellular levels and mainly affects the cardiovascular system and liver. The drug side effects increased on repeated administration. Combined use of alcohol and nicotine does not lead to potentiation of their toxic effect on the developing embryo.
