ABSTRACT
BACKGROUND: We report changes in MRI brain of children with Infantile Tremor Syndrome (ITS) at the onset of illness and following treatment. CASE CHARACTERISTICS: Three children with infantile tremor syndrome were assessed for changes in brain neuroimaging at admission and at follow-up visit. On MRI, all children had mild to severe diffuse cerebral atrophy, which reverted back to normal on follow-up visits. OUTCOME: Children with infantile tremor syndrome have reversible diffuse cerebral atrophy on neuroimaging.
Subject(s)
Brain Diseases , Brain , Tremor/diagnosis , Atrophy , Brain/diagnostic imaging , Brain/pathology , Brain Diseases/diagnostic imaging , Brain Diseases/pathology , Female , Humans , Infant , Magnetic Resonance Imaging , Malnutrition/therapy , Propranolol/therapeutic use , Treatment Outcome , Tremor/drug therapyABSTRACT
OBJECTIVE: To study the role of Vitamin B12 as an etiological factor in patients of infantile tremor syndrome (ITS). METHODS: Twelve consecutive admissions of children diagnosed clinically as ITS were assessed. Assessment was done using a predefined pro forma to document patient demographic factors, general examination, systemic examination as well as relevant hematological and biochemical investigations. RESULTS: Out of the 12 cases of ITS, 6 were males and 6 were females. Two cases had serum B12 levels below reference values, five had levels in low normal range, and remaining five had normal values. CONCLUSIONS: Role of Vitamin B12 deficiency as an etiological factor in the patients of ITS is inconclusive.
