ABSTRACT
The development of green and sustainable processes to synthesize active pharmaceutical ingredients and key starting materials is a priority for the pharmaceutical industry. A green and sustainable protocol for the oxidative cleavage of olefins to produce pharmaceutically and biologically valuable carboxylic acids is achieved. The developed protocol involves 70% aq. TBHP as an oxidant over a heterogeneous vanadium catalyst system. Notably, the synthesis of industrially important azelaic acid from various renewable vegetable oils is accomplished. The catalyst could be recycled for up to 5 cycles without significant loss in yield and the protocol was successfully demonstrated at the gram-scale.
ABSTRACT
A novel formic acid-assisted rapid and efficient route for C-S bond construction via the thiol-ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing different functionalities were well tolerated. The reaction also provided a good yield of sulfones in a one-pot two-step protocol. The developed method is operationally simple, green, metal-free, solvent-free, and having a high atom economy with high regioselectivity.
