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1.
Nat Commun ; 13(1): 1011, 2022 Feb 23.
Article in English | MEDLINE | ID: mdl-35197491

ABSTRACT

Strong electronic nematic fluctuations have been discovered near optimal doping for several families of Fe-based superconductors, motivating the search for a possible link between these fluctuations, nematic quantum criticality, and high temperature superconductivity. Here we probe a key prediction of quantum criticality, namely power-law dependence of the associated nematic susceptibility as a function of composition and temperature approaching the compositionally tuned putative quantum critical point. To probe the 'bare' quantum critical point requires suppression of the superconducting state, which we achieve by using large magnetic fields, up to 45 T, while performing elastoresistivity measurements to follow the nematic susceptibility. We performed these measurements for the prototypical electron-doped pnictide, Ba(Fe1-xCox)2As2, over a dense comb of dopings. We find that close to the putative quantum critical point, the elastoresistivity appears to obey power-law behavior as a function of composition over almost a decade of variation in composition. Paradoxically, however, we also find that the temperature dependence for compositions close to the critical value cannot be described by a single power law.

2.
J Neural Eng ; 8(3): 036014, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21525568

ABSTRACT

Several recent studies have demonstrated that neuronal models allow multiple parameter value solutions for a given output. In the face of this variability of parameter values, what can be learned about neural function through parameter value differences? Here, in two different models, we examine this question by attempting to reconstruct the source of model output changes based on simple statistical analyses of parameter distributions generated by automated searches. We conclude that changes to parameter values or their associated distributions do not reliably reflect the specific mechanisms responsible for a given change in output.


Subject(s)
Action Potentials/physiology , Biological Clocks/physiology , Models, Neurological , Neurons/physiology , Pattern Recognition, Automated/methods , Synaptic Transmission/physiology , Animals , Computer Simulation , Humans , Models, Statistical
3.
J Neural Eng ; 4(3): 189-96, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17873420

ABSTRACT

Neural models are increasingly being used as design components of physical systems. In order to best use models in these novel contexts, we must develop design rules that describe how decisions in model construction relate to the functional performance of the resulting system. In the accompanying paper, we described a series of related neuron models of varying complexity. Here, we use these models to build several half-center oscillators, and investigate how model complexity influences the robustness and flexibility of these oscillators. Our results indicate that model complexity has a significant effect on the robustness and flexibility of systems that incorporate neural models.


Subject(s)
Action Potentials/physiology , Algorithms , Biological Clocks/physiology , Models, Neurological , Nerve Net/physiology , Neurons/physiology , Periodicity , Animals , Computer Simulation , Feedback/physiology , Humans
4.
J Neural Eng ; 4(3): 179-88, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17873419

ABSTRACT

Neural models are increasingly being used as design components of physical systems. In order to most effectively utilize neuronal models in these novel contexts, we need to develop design rules for neuronal systems that relate how model design affects overall system performance. In this paper and a companion article, we investigate how the complexity of a neural model affects the performance of a two-cell oscillator built from the model. In this paper, we create a series of related neuron models with different mathematical complexity. Starting with a complex mechanistic model of a bursting neuron, we use a variety of techniques to create a series of simplified neuron models. These three reduced models produce bursting activity that is qualitatively very similar to the original model. In the following companion article, we investigate the functional performance of oscillators built from these models.


Subject(s)
Action Potentials/physiology , Algorithms , Biological Clocks/physiology , Models, Neurological , Nerve Net/physiology , Neurons/physiology , Periodicity , Animals , Computer Simulation , Feedback/physiology , Humans
5.
Am J Nurs ; 86(10): 1171-2, 1986 Oct.
Article in English | MEDLINE | ID: mdl-3639709
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