A critical review on the ecotoxicity of heavy metal on multispecies in global context: A bibliometric analysis.

Heavy metals (HMs) have become a significant concern in the current era, with deleterious effects on diverse living organisms when exposed beyond threshold concentrations. Both nature and human beings have been constantly casting out HMs into environmental matrices through various activities. Innumerable cases of threatened diseases such as cancer, respiratory ailments, reproductive defects, skin diseases, and several others have been a cause of significant concern for humans as the number of instances has been increasing with each decade. HMs migrates via several pathways to infiltrate biological organisms and amass within them. Even though numerous treatment approaches are available for remediating HM pollution, however, they are expensive, along with other setbacks. Due to such constraints, combating HM contamination requires environmentally conscious strategies like bioremediation, which employs an array of biological systems to remove HMs from the environment. Nonetheless, to address the current global HM pollution situation, it is critical to comprehend not only how these hazardous HMs cause toxicity in various living organisms but also the knowledge gaps that currently exist concerning the subject of HM ecotoxicity. In the present investigation, data was extracted from Google Scholar using software program called Harzing's Publish or Perish. The collected information has been subsequently displayed as a network file using the VOSViewer software tool. Thus, the current review presents a significant insight with the inclusion of a readily accessible bibliometric analysis to comprehend the present status of HMs research, global research trends, existing knowledge discrepancies, and research challenges. Further, it also provides an in-depth review of HMs ecotoxicity, with a focus on arsenic (As), cadmium (Cd), and lead (Pb). Thus, as indicated by the bibliometric study, the present review will assist future investigators studying HMs ecotoxicity by providing baseline data concerning a wide range of living organisms and by addressing research gaps.

Autochthonous psychrophilic hydrocarbonoclastic bacteria and its ecological function in contaminated cold environments.

Petroleum hydrocarbon (PH) pollution has mostly been caused by oil exploration, extraction, and transportation activities in colder regions, particularly in the Arctic and Antarctic regions, where it serves as a primary source of energy. Due to the resilience feature of nature, such polluted environments become the realized ecological niches for a wide community of psychrophilic hydrocarbonoclastic bacteria (PHcB). In contrast, to other psychrophilic species, PHcB is extremely cold-adapted and has unique characteristics that allow them to thrive in greater parts of the cold environment burdened with PHs. The stated group of bacteria in its ecological niche aids in the breakdown of litter, turnover of nutrients, cycling of carbon and nutrients, and bioremediation. Although such bacteria are the pioneers of harsh colder environments, their growth and distribution remain under the influence of various biotic and abiotic factors of the environment. The review discusses the prevalence of PHcB community in colder habitats, the metabolic processes involved in the biodegradation of PH, and the influence of biotic and abiotic stress factors. The existing understanding of the PH metabolism by PHcB offers confirmation of excellent enzymatic proficiency with high cold stability. The discovery of more flexible PH degrading strategies used by PHcB in colder environments could have a significant beneficial outcome on existing bioremediation technologies. Still, PHcB is least explored for other industrial and biotechnological applications as compared to non-PHcB psychrophiles. The present review highlights the pros and cons of the existing bioremediation technologies as well as the potential of different bioaugmentation processes for the effective removal of PH from the contaminated cold environment. Such research will not only serve to investigate the effects of pollution on the basic functional relationships that form the cold ecosystem but also to assess the efficacy of various remediation solutions for diverse settings and climatic conditions.

In-situ biofabrication of bacterial nanocellulose (BNC)/graphene oxide (GO) nano-biocomposite and study of its cationic dyes adsorption properties.

In the present study, bacterial nanocellulose/graphene oxide nano-biocomposites (BNC-GO-NBCs) were fabricated by Komagataeibacter saccharivorans NUWB1 using an in-situ method involving three time-dependent approaches. Physicochemical studies showed that the chosen dried BNC-GO-NBC possessed a three-dimensional interconnected porous structure of BNC with GO layers embedded within the BNC fibrils. BNC-GO-NBC had a crystallinity index of 74.21 %, higher thermostability up to 380 °C and could withstand a tensile load of 84.72 MPa. N2 adsorption-desorption isotherm of the BNC-GO-NBC was found to be of type IV, suggesting a mesoporous type structure with a total pore volume and surface area of 6.232e-04 cc g-1 and 10.498 m2. BNC-GO-NBC exhibited remarkable adsorption capacity for two cationic dyes, Rhodamine B (RhB) and Acridine Orange (AO), and the adsorption data conformed well to the Langmuir isotherm (R2 = 0.99) and pseudo-second-order model. Thermodynamic studies indicated that the adsorption process was spontaneous and endothermic. Additionally, the BNC-GO-NBC displayed the potential for regeneration, with the ability to be recycled up to five times. Further, the antibacterial activity, cell cytotoxicity and oxidative stress assays of the BNC-GO-NBC revealed its non-cytotoxic nature. The findings of the present investigation evidently suggest the potentiality of BNC-GO-NBC in the application of dye adsorption and other environmental applications.

Environmentally benign synthesis of unsymmetrical ureas and their evaluation as potential HIV-1 protease inhibitors via a computational approach.

The present work reports the cost-effective, high yielding and environmentally acceptable preparation of unsymmetrical ureas from thiocarbamate salts using sodium percarbonate as an oxidant. Efficacy of the unsymmetrical ureas as potential human immune deficiency virus (HIV-1) protease inhibitors has been evaluated via in silico approach. The results revealed interactions of the urea compounds at the active site of the enzyme with favorable binding affinities causing possible mutations hindering the functioning of the enzyme. Further computational assessment of IC50 using known references satisfactorily authenticated the inhibitory action of the selected compounds against HIV-1 protease. Added to the easy synthesis of the ureas following an environmentally benign protocol, this work may be a valuable addition to the ongoing search for drugs with better efficacy profiles and reduced toxicity against HIV.

PHA-Based Bioplastic: a Potential Alternative to Address Microplastic Pollution.

Petroleum-derived plastics are linked to a variety of growing environmental issues throughout their lifecycle, including emission of greenhouse gases, accumulation in terrestrial and marine habitats, pollution, among others. There has been a lot of attention over the last decade in industrial and research communities in developing and producing eco-friendly polymers to deal with the current environmental issues. Bioplastics preferably are a fast-developing family of polymeric substances that are frequently promoted as substitutes to petroleum-derived plastics. Polyhydroxyalkanoates (PHAs) have a number of appealing properties that make PHAs a feasible source material for bioplastics, either as a direct replacement of petroleum-derived plastics or as a blend with elements derived from natural origin, fabricated biodegradable polymers, and/or non-biodegradable polymers. Among the most promising PHAs, polyhydroxybutyrates (PHBs) are the most well-known and have a significant potential to replace traditional plastics. These biodegradable plastics decompose faster after decomposing into carbon dioxide, water, and inorganic chemicals. Bioplastics have been extensively utilized in several sectors such as food-processing industry, medical, agriculture, automobile industry, etc. However, it is also associated with disadvantages like high cost, uneconomic feasibility, brittleness, and hydrophilic nature. A variety of tactics have been explored to improve the qualities of bioplastics, with the most prevalent being the development of gas and water barrier properties. The prime objective of this study is to review the current knowledge on PHAs and provide a brief introduction to PHAs, which have drawn attention as a possible potential alternative to conventional plastics due to their biological origin, biocompatibility, and biodegradability, thereby reducing the negative impact of microplastics in the environment. This review may help trigger further scientific interest to thoroughly research on PHAs as a sustainable option to greener bioplastics.

Bioprospecting of indigenous biosurfactant-producing oleophilic bacteria for green remediation: an eco-sustainable approach for the management of petroleum contaminated soil.

In the present study, the efficiency of four different strains of Pseudomonas aeruginosa and their biosurfactants in the bioremediation process were investigated. The strains were found to be capable of metabolizing a wide range of hydrocarbons (HCs) with preference for high molecular weight aliphatic (ALP) over aromatic (ARO) compounds. After treating with individual bacteria and 11 different consortia, the residual crude oils were quantified and qualitatively analyzed. The bacterial strains degraded ALP, ARO, and nitrogen, sulphur, oxygen (NSO) containing fractions of the crude oil by 73-67.5, 31.8-12.3 and 14.7-7.3%, respectively. Additionally, the viscosity of the residual crude oil reduced from 48.7 to 34.6-39 mPa s. Further, consortium designated as 7 and 11 improved the degradation of ALP, ARO, and NSO HCs portions by 80.4-78.6, 42.7-42.4 and 21.6-19.2%, respectively. Moreover, addition of biosurfactant further increased the degradation performance of consortia by 81.6-80.7, 43.8-42.6 and 22.5-20.7%, respectively. Gas chromatographic analysis confirmed the ability of the individual strains and their consortium to degrade various fractions of crude oil. Experiments with biosurfactants revealed that polyaromatic hydrocarbons (PAHs) are more soluble in the presence of biosurfactants. Phenanthrene had the highest solubility among the tested PAHs, which further increased as biosurfactant doses raised above their respective critical micelle concentrations (CMC). Furthermore, biosurfactants were able to recover 73.5-63.4% of residual oil from the sludge within their respective CMCs. Hence, selected surfactant-producing bacteria and their consortium could be useful in developing a greener and eco-sustainable way for removing crude oil pollutants from soil.