ABSTRACT
The high sensitivity C-reactive protein (hs-CRP) is an important biomarker in inflammatory processes. The objective was to analyze the relationship between the concentrations of hs-CRP in adults from a northern Mexico region with their typical food intake patterns. A sample of 72 university professors underwent clinical and anthropometric assessments and their hs-CRP levels were quantified with an immunoenzymometric assay. Additionally, they filled out a food intake frequency questionnaire, from which the servings of different food groups were obtained with the ESHA software. The average age of participants was 49.75 +/- 10.05 years and the average hs-CRP concentration was 1.66 (0.97, 3.52) mg/L. The value of the association between fruit consumption and hs-CRP level was protective, according to the logistic regression analysis, being the Odds Ratio (OR) 0.23 (95% CI: 0.05, 1.03); while for vegetables the OR was 0.66 (95% CI: 0.12, 3.68). Furthermore, high protein content foods, dairy products, oils and fats were associated with elevated levels of hs-CRP. In conclusion, in our study, the intake of some food groups like fruits and vegetables, and to a lesser extent cereals, were associated with low values of hs-PCR.
Subject(s)
C-Reactive Protein/analysis , Diet , Inflammation/blood , Adult , Anthropometry , Dairy Products , Dietary Fats , Edible Grain , Feeding Behavior , Female , Food/classification , Fruit , Humans , Inflammation/epidemiology , Inflammation/etiology , Male , Meat , Mexico , Middle Aged , Reference Values , VegetablesABSTRACT
La proteína C-reactiva ultrasensible (PCR-us) es un biomarcador importante en procesos inflamatorios. El objetivo del estudio fue examinar la relación entre la concentración de la PCR-us de adultos aparentemente sanos, con su patrón alimentario característico del norte de México. A una muestra de 72 profesores universitarios se les realizó una valoración clínica y antropométrica y se les cuantificó la PCR-us con un ensayo inmunoenzimométrico (EIA). Los profesores además contestaron un cuestionario de frecuencia de consumo de alimentos, del cual se estimaron las raciones de grupos de alimentos con el programa ESHA. La edad promedio de los participantes fue 49,75 ±10,05 años y la concentración de PCR-us tuvo un promedio de 1,66 (0,97 a 3,52) mg/L. La magnitud de la asociación entre el consumo de frutas y el nivel de PCR-us fue protectora de acuerdo con el análisis de regresión logística cuya Razón de Momios (RM) fue de 0,23 (95% IC: 0,05 a 1,03), mientras que para los vegetales la RM fue de 0,66 (95% IC: 0,12 a 3,68). Por otro lado, los alimentos proteicos, lácteos, aceites y grasas se asociaron con niveles elevados de la PCR-us. En conclusión, la menor concentración de la PCR-us se asoció con la mayor ingesta de los grupos de frutas y vegetales, y en menor grado con los cereales.
The high sensitivity C-reactive protein (hs-CRP) is an important biomarker in inflammatory processes. The objective was to analyze the relationship between the concentrations of hs-CRP in adults from a northern Mexico region with their typical food intake patterns. A sample of 72 university professors underwent clinical and anthropometric assessments and their hs-CRP levels were quantified with an immunoenzymometric assay. Additionally, they filled out a food intake frequency questionnaire, from which the servings of different food groups were obtained with the ESHA software. The average age of participants was 49.75 ± 10.05 years and the average hs-CRP concentration was 1.66 (0.97, 3.52) mg/L. The value of the association between fruit consumption and hs-CRP level was protective, according to the logistic regression analysis, being the Odds Ratio (OR) 0.23 (95% CI: 0.05, 1.03); while for vegetables the OR was 0.66 (95% CI: 0.12, 3.68). Furthermore, high protein content foods, dairy products, oils and fats were associated with elevated levels of hs-CRP. In conclusion, in our study, the intake of some food groups like fruits and vegetables, and to a lesser extent cereals, were associated with low values of hs-PCR.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , C-Reactive Protein/analysis , Diet , Inflammation/blood , Anthropometry , Dairy Products , Dietary Fats , Edible Grain , Feeding Behavior , Fruit , Food/classification , Inflammation/epidemiology , Inflammation/etiology , Meat , Mexico , Reference Values , VegetablesABSTRACT
Isoniazid (INH) is a drug extensively used as a prophylactic and therapeutic agent for human tuberculosis (TB). INH is metabolized by the enzymatic activity of N-acetyltransferase 2 (NAT2). Human NAT2, encoded by a highly polymorphic gene, is involved in the biotransformation of xenobiotics, including drugs and certain chemical carcinogens. Numerous studies have established the correlation between the acetylator phenotype and the NAT2 genotype in several populations; however, little is known regarding Latin-American populations and the pharmacogenetics of NAT2. Here, we report the molecular genotyping of the NAT2 gene, the acetylator phenotype, and the incidence of INH-related adverse reactions in a group of 25 Mexican individuals enrolled in a prophylactic protocol for TB. Using both the NAT2 genotyping and acetylation phenotyping approach, we found a ratio of 69.2 and 30.8% of slow and fast acetylators, respectively. Concordance of the NAT2 genotype and phenotype classification was 88% in the bimodal model. Regarding INH-related adverse reactions, only 2 individuals (8%) exhibited declared gastric intolerance. In our study group, we found an association between the NAT2 genotype and acetylator phenotype (OR=7.78, 95% CI, 0.87-87.98, Fisher's exact test, p<0.05), but did not find any genotype or phenotype association with the incidence of INH-related adverse reactions (Fisher's exact test, p>0.05).
