A simple instrument to assess the risk of falling in postpartum women: the SLOPE scale (riSk of faLling in pOstPartum womEn).

The purpose of this study was to introduce a novel instrument aimed at stratifying the risk of falling in postpartum patients. The research was a survey of a sample of 460 midwives working at different hospitals, mainly in Northern Italy, except for a hospital in Rome (Italy). The survey, consisting of 70 items, was conducted among midwives and asked them to express their opinion regarding the increased risk of falling in puerperal women on a Likert scale according to the characteristics listed in the questionnaire. Items were derived from the synthesis of scales available in the literature from settings other than the postpartum period, and interviews were conducted with midwives with great experience in this area. A shortened version was obtained using principal component analysis. A 30-item final scale was obtained, the SLOPE (riSk of faLling in pOst-Partum womEn), ranging from 0 to 100. The scale allows stratification of postpartum women at low (0-10), intermediate (10-20) and high risk (>20) of falling. The development of the SLOPE scale is the first step towards more rational evidence-based management of the risk of falling in postpartum women in current clinical practice.Impact statementWhat is already known on this subject? Falls occurring in the postnatal period are not limited to women because infants are often involved in this adverse event, with several significant consequences. There is a lack of information on this issue due to the absence of both registries and scales for the prevention of falls.What do the results of this study add? The main result of this study is the development of a novel scale to assess the falling risk in postpartum women.What are the implications of these findings for clinical practice and/or further research? The development of this novel scale, even if based on midwives' experience and not on patients' data, is a first step towards a more rational evidence-based management of the risk of falling in postpartum women.

Overrunning in clinical trials: some thoughts from a methodological review.

BACKGROUND: In sequential and adaptive trials, the delay that happens after the trial is stopped, by a predetermined stopping criterion, takes the name of overrunning. Overrunning consists of extra data, collected by investigators while awaiting results of the interim analysis (IA). The inclusion of such extra data in the analyses is scientifically appropriate and follows regulatory advice. Nevertheless, its effect from a broader perspective is unclear. METHODS: This article aims at clarifying the overall impact of including such overrunning data, providing first a revision, and then a comparison of the several approaches proposed in the literature for treating such data. A simulation study is performed based on two real-life examples. RESULTS: The paper shows that overrunning inclusion could seriously change the decision of an early conclusion of the study. It also shows that some of the methods proposed in the literature to include overrunning data are more conservative than others. CONCLUSION: The choice of a more or a less conservative method could be considered more appropriate depending on the endpoint type or the design type.

Effect of Online Health Information Seeking on Anxiety in Hospitalized Pregnant Women: Cohort Study.

BACKGROUND: There are approximately 1,000,000 pregnant women at high risk for obstetric complications per year, more than half of whom require hospitalization. OBJECTIVE: The aim of this study was to determine the relation between online health information seeking and anxiety levels in a sample of hospitalized woman with pregnancy-related complications. METHODS: A sample of 105 pregnant women hospitalized in northern Italy, all with an obstetric complication diagnosis, completed different questionnaires: Use of Internet Health-information (UIH) questionnaire about use of the internet, EuroQOL 5 dimensions (EQ-5D) questionnaire on quality of life, State-Trait Anxiety Inventory (STAI) questionnaire measuring general anxiety levels, and a questionnaire about critical events occurring during hospitalization. RESULTS: Overall, 98/105 (93.3%) of the women used the internet at home to obtain nonspecific information about health in general and 95/105 (90.5%) of the women used the internet to specifically search for information related to their obstetric disease. Online health information-seeking behavior substantially decreased the self-reported anxiety levels (P=.008). CONCLUSIONS: Web browsing for health information was associated with anxiety reduction, suggesting that the internet can be a useful instrument in supporting professional intervention to control and possibly reduce discomfort and anxiety for women during complicated pregnancies.

Protocols for early discharging of premature infants: an empirical assessment on safety and savings.

Background Preterm newborns may be discharged when clinical conditions are stable. Several criteria for early discharge have been proposed in the literature. This study carried out the first quantitative comparison of their impact in terms of hospitalization savings, safety and costs. Methods This study was based on the clinical histories of 213 premature infants born in the Neonatal Intensive Care Unit of Padova University Hospital between 2013 and 2014. Seventeen early discharge criteria were drawn from the literature and retrospectively applied to these data, and computation of hospitalization savings, safety and costs implied by each criterion was carried out. Results Among the criteria considered, average gains ranged from 1.1 to 10.3 hospital days and between 0.3 and 1.1 fewer infections per discharged infant. Criteria that led to saving more hospital days had higher cost-effectiveness in terms of crisis and infection, and they spared infants from more infections. However, episodes of apnea and bradycardia were detected after the potential early discharge date for all criteria, with a mean number of episodes numbering between 0.3 and 1.4. Conclusion The results highlight a clear trade-off between days saved and health risks for infants, with potential consequences for health care costs.

Temporal and regional trends of choking injuries in children in Italy, 2001-2013.

BACKGROUND: Choking injuries in children are a significant public health problem. The present study was aimed at examining the epidemiologic patterns of choking injuries in children using Italian official data from hospital discharge records. METHODS: Hospital discharge records (from 2001 to 2013) reporting cases of choking injuries corresponding to the ICD-9 CM codes 933 ("Foreign body in pharynx and larynx"), 934 ("Foreign body in trachea, bronchus, and lung"), and fourth digit specifications (933.0 "pharynx", 933.1 "larynx", 934.0 "trachea", 934.1 "main bronchus", 934.8 "other specified parts", 934.9 "respiratory tree, unspecified") occurred in children aged 0-14 years were analyzed to assess the temporal and regional trends. Annual rates of hospitalizations due to choking injuries per 100,000 person-years were calculated and compared between boys and girls. RESULTS: During the 13-year study period, there were a total of 7143 hospitalizations due to choking injuries in Italian children. The annual rates of hospitalizations due to choking injuries per 100,000 person-years decreased from 5.28 in 2001 to 3.46 in 2013 (p < 0.001). The reduction in choking injuries occurred across all the regions, particularly in Campania, Lombardia, Puglia, and Veneto. CONCLUSIONS: Hospitalizations for choking injuries in Italian children have decreased significantly in recent years. Choking injuries in children remain a cause of concern in some regions. Future research needs to elicit the causal factors underlying the downward trends and regional variations and develop targeted interventions to further reduce choking injuries in Italian children.

Prognostic impact of leaflet-to-annulus index in patients treated with transapical off-pump echo-guided mitral valve repair with NeoChord implantation.

BACKGROUND: The transapical echo-guided NeoChord repair is a procedure to correct mitral regurgitation (MR) without the need for concomitant annuloplasty for degenerative mitral valve (MV) disease. Lacking strict criteria to define normal annular dimensions for patients undergoing MV repair, we consequently missed having precise selection criteria to identify patients who can benefit from a ringless procedure with respect to who would need a combined annular and leaflet repair. The aim of this study is to identify whether a new preoperative echocardiographic index may predict postoperative outcomes after NeoChord repair. METHODS: All consecutive patients with posterior leaflet disease who underwent NeoChord repair between November 2013 and January 2016 presenting complete postoperative echocardiographic assessment up to 1year were included. Leaflet-to-Annulus Index (LAI) was defined as the ratio between the sum of anterior leaflet length (AML) and posterior leaflet length (PML) over antero-posterior length (AP; AML+PML/AP). Measurements were performed with 2D transesophageal echocardiography. RESULTS: Sixty-six patients were enrolled. At 1year MR was absent in (24) 38% of patients, mild in (28) 44%, moderate in (10) 16% and severe in (1) 2%. Logistic regression analysis identified LAI as positive prognostic predictor of MR≤mild for values >1.35 at 3months, 1.30 at 6months and 1.25 at 1year. At 30days LAI was not associated with the grade of residual MR. CONCLUSIONS: LAI is a positive postoperative predictor of MR≤mild at 1-year follow-up and can be used to identify patients who could benefit from a ringless NeoChord repair procedure for the absence of a leaflet-to-annulus mismatch.

Acute intraoperative echocardiographic changes after transapical off-pump mitral valve repair with NeoChord implantation.

OBJECTIVES: Our aim is to investigate the acute intraoperative effects of the NeoChord repair procedure on mitral valve (MV) annular geometry and LV function and the impact of these changes on MR at 1-year follow-up. BACKGROUND: Recently transapical off-pump mitral valve repair with NeoChord implantation has been demonstrated to be safe and effective in patients with degenerative mitral regurgitation (DMR). METHODS: We retrospectively analyzed baseline and early postoperative 3-dimensional transesophageal echocardiography of 66 patients who underwent NeoChord repair for isolated posterior leaflet MV disease using semiautomatic off-line analysis software. RESULTS: We observed a significant acute reduction of indexed LV end diastolic volume (Δ% = 14, p < .001), LV ejection fraction (Δ = 5.7%, p = .002), indexed left atrial volume (Δ = 14.7%, p = .045), and pulmonary artery pressure (Δ = 2.1%, p = .026). Among MV geometric parameters, we observed a significant reduction of MV antero-posterior diameter (Δ = 7%, p < .001), sphericity index (Δ = 8%, p < .001), annulus circumference (Δ = 0.9%, p = .021), and annulus area (Δ = 2.7%, p = .018). At 1-year, 53 patients (85.5%) presented MR ≤ mild, while 9 patients (14.5%) had MR ≥ moderate. Reduction of AP diameter (OR = 0.14, CI -3.83; 0.08, p < .001), annulus circumference (OR = 0.27, CI -2.98; 0.37, p = .005), MV area (OR = 0.39, CI -2.46; 0.61, p = .04), aorto-mitral angle (OR = 0.38, CI -2.49; 0.54, p = .002) and iEDV (OR = 0.44, CI -2.44; 0.81, p = .001) were independent protective factors against recurrence of MR greater than mild at 1-year follow-up. CONCLUSIONS: Transapical NeoChord repair produces important acute intraoperative changes in MV anatomy in DMR patients. The acute changes observed were associated with procedure durability at 1-year FU.

Evaluating therapeutic effect on WOMAC subscales in osteoarthritis RCTs: When model choice matters.

RATIONALE, AIMS, AND OBJECTIVES: The study aimed at developing a method for modelling the Western Ontario and McMaster Universities index (WOMAC), accounting for correlation between its subscales and for heterogeneity of treatment effect (HTE), using data from 2 twin trials on knee osteoarthritis. METHOD: Two randomized, double-blind, placebo-controlled clinical trials (twin trials). Studies aimed at investigating the effectiveness of a pharmacological treatment on clinical outcomes of knee osteoarthritis, measured using WOMAC index. To take into account that the WOMAC subscales are correlated and skewed, we proposed and compared multivariate gamma and Gaussian approaches with latent variable capturing correlation between outcomes. Besides the latent term, the interaction between the latent term and treatment, accounting for HTE, was further estimated. RESULTS: Modelling the subscales by using a gamma approach accounting for skewness of data, we found out different results compared with Gaussian models. The main difference regarded the latent variable interacting with treatment (accounting for unobserved heterogeneity), which is not significant for the Gaussian approach (P value = .102) and significant in the gamma model (P value < .002). Thus, indicating that unobserved covariates affect treatment's performance. Additionally, plotting the observed and the estimated values of WOMAC index of the Gaussian and gamma models, we showed that, compared with the Gaussian, the gamma one best fits the data, especially among poor responders. CONCLUSION: Multivariate gamma approach accounting for correlation between outcomes and for HTE has been demonstrated to be more suitable to model WOMAC subscales and to provide more information on effect of therapy.

High Agreement and High Prevalence: The Paradox of Cohen's Kappa.

BACKGROUND: Cohen's Kappa is the most used agreement statistic in literature. However, under certain conditions, it is affected by a paradox which returns biased estimates of the statistic itself. OBJECTIVE: The aim of the study is to provide sufficient information which allows the reader to make an informed choice of the correct agreement measure, by underlining some optimal properties of Gwet's AC1 in comparison to Cohen's Kappa, using a real data example. METHOD: During the process of literature review, we have asked a panel of three evaluators to come up with a judgment on the quality of 57 randomized controlled trials assigning a score to each trial using the Jadad scale. The quality was evaluated according to the following dimensions: adopted design, randomization unit, type of primary endpoint. With respect to each of the above described features, the agreement between the three evaluators has been calculated using Cohen's Kappa statistic and Gwet's AC1 statistic and, finally, the values have been compared with the observed agreement. RESULTS: The values of the Cohen's Kappa statistic would lead to believe that the agreement levels for the variables Unit, Design and Primary Endpoints are totally unsatisfactory. The AC1 statistic, on the contrary, shows plausible values which are in line with the respective values of the observed concordance. CONCLUSION: We conclude that it would always be appropriate to adopt the AC1 statistic, thus bypassing any risk of incurring the paradox and drawing wrong conclusions about the results of agreement analysis.

A Social Network Approach to the Estimation of Perceived Quality of Health Care.

BACKGROUND: Measuring service quality aids health care providers to recognize specific and unmet needs of patients. Nevertheless, perceived quality of health care services (PQC) is often investigated with inadequate techniques which may lead to biased results. OBJECTIVE: The aim of the present study is to develop a proof-of-concept for estimating the PQC using the scale-up estimator, with reference to a concrete assessment in patients of a major Oncology Hospital in Veneto (IOV). Results have then been compared with those collected by the Customer Relations Office (CRO) after the annual survey conducted with traditional questionnaire based techniques. MATERIAL AND METHODS: Seven hundred and eighty-three sets consisting of two questionnaires were handed out to IOV patients between 26 and 28 November 2012. The first questionnaire was the CRO annual one composed by 15 direct questions about the perception of quality satisfaction rate using a Likert scale. The second questionnaire was the scale-up (NSUM) one, composed by 20 indirect questions, 5 of which were reproducing the main target of CRO for estimating PQC. RESULTS: The comparisons made over 299 sets of questionnaires showed differences between the two techniques. Network Scale-Up Method (NSUM) questionnaire seems to be able to produce lower estimates of PQC with respect to the CRO annual questionnaire. In some cases, the NSUM showed dissatisfaction rates which are 20-fold higher respect to CRO. CONCLUSION: NSUM could be a promising method for assessing the perceived quality of care.

Association between simple anthropometric measures in children of different ethnicities: results from the OBEY-AD study

Body mass index (BMI) is considered a good predictor of overall adiposity, with significant sensitivities in identifying overweight children. Recently, it has been suggested that other anthropometric measures may also be employed as adequate surrogates for imaging techniques and BMI. However, it is well known that differences exist in body fat distribution among different ethnicities. The present study aims at assessing the relationship between anthropometric measures in children from different geographical regions. The OBEY-AD is an international study enrolling 2720 children (3-11 years of age), balanced by gender. Children underwent anthropometric assessment. The association between these anthropometric measures was estimated using linear mixed models. South-American children had a higher BMI and waist and hip circumference compared to European and Indian ones. Conversely, Indian children were found to be taller and to have a higher waisthip ratio than those of European and South-American kids, suggesting a different body composition of Indian children compared to those of the other ethnic groups. Overall, this data provides further evidence on the differences in anthropometric measures between the Indian, South American and European child populations(AU)

El índice de masa corporal (IMC) es considerado un buen indicador de adiposidad general, con una capacidad significativa para la identificación de niños con sobrepeso. Recientemente, se ha sugerido que también es posible utilizar otras medidas antropométricas como sustitutos adecuados de las técnicas de diagnóstico por imagen y del IMC. Sin embargo, es bien sabido que existen diferencias en la distribución de la grasa corporal entre diferentes grupos étnicos. El objetivo del presente estudio es evaluar la relación entre las medidas antropométricas en niños de diferentes regiones geográficas. El OBEYAD es un estudio internacional que incluyó a 2720 niños (de entre 3 y 11 años de edad), equilibrados por sexo. A los niños se les realizó una evaluación antropométrica. Se realizó la estimación de la asociación entre estas medidas antropométricas por medio de modelos lineales mixtos. Los niños de América del Sur tuvieron valores más altos de IMC, circunferencia de cintura y cadera, en comparación con los resultados de los niños europeos e hindúes. Por el contrario, se encontró que los niños de la India tenían una mayor estatura y una relación cintura-cadera mayor que la de los niños europeos y sudamericanos, lo que sugiere la existencia de una composición corporal diferente en los niños hindúes respecto de los de los otros grupos étnicos. Este hallazgo fue confirmado asimismo en el modelo lineal. En general, estos datos proporcionan evidencia adicional sobre las diferencias en las medidas antropométricas entre la población infantil de la India, de América del Sur y de Europa(AU)

Is branding food promoting obesity? An investigation on children in San Luis Potosí

This study aims at assessing children's awareness towards branded food products in central Mexico. One-hundred and twenty children, aged 3-10 years and balanced by gender, were recruited in San Luis Potosí. Kids' heights and weights were measured in order to calculate their BMI. A cross-sectional questionnaire was administered to children's parents in order to gain socio-demographic information. Children's brand awareness was assessed using the IBAI (International Brand Awareness Inventory). Basic exploratory analyses were performed for samples' general characteristics, and ANOVA was adopted for investigating differences between the IBAI tasks. Results demonstrated that 50% of kids correctly associated the logo to the respective brand in more than 70% of the cases. About half of the sample recalled the right name of the food type in 50% of the cases. 50% of kids recognized the brand name in less than 20% of cases. Older children (7-10 y) showed a higher brand awareness when compared to younger ones (3-6 y). Children demonstrated a consistent knowledge of famous fast-food and snack products. Prevention through informative campaigns should make parents more aware of the TV contents, their kids are exposed to(AU)

Este estudio tiene como objetivo evaluar la conciencia de los niños hacia los productos alimenticios de marca en México. Ciento veinte niños, de entre 3-10 años en grupos equitativos por sexos, fueron reclutados en San Luis Potosí. Se midieron la talla y los pesos de los niños con el fin de calcular sus IMC. A los padres de los niños se les entrego un cuestionario transversal a fines de obtener información socio-demográfica. El conocimiento de la marca de los niños se evaluó, mediante el uso del IBAI (Inventario Internacional de conocimiento de la marca). Se realizó un análisis exploratorio de base para obtener las características generales de la muestra y se adoptó un anova para investigar las diferencias entre las tareas ibai . Los resultados demostraron que el 50% de los niños había asociado correctamente el logotipo de la marca respectiva en más del 70% de los casos. Aproximadamente la mitad de la muestra recordaba el nombre correcto de marca de alimentos en el 50% de los casos. 50% de los niños reconocía el nombre de la marca en menos del 20% de los casos. Los niños mayores (7-10 años) mostraron una conciencia de marca más alta si se compara con los más jóvenes (3-6 años). Los niños demostraron consistentemente tener conocimiento de los productos de comida rápida y bocadillos más conocidos. La prevención a través de campañas informativas debería conscientizar a los padres sobre los contenidos de televisión a los que que sus hijos están expuestos(AU)

Dietary patterns in Mexico and obesity in children

his cross-sectional study aims to investigate food habits, socio-economic status and blood lipids profile in schoolchildren (10-11 years of age) living in a low-income area of Mexico (the city of Montemorelos), characterizing lipid concentrations among children obese and evaluating the impact of socio-economic factors and dietary habits on blood lipids profile of these children. Complete data were available for 156 children (78 boys and 78 girls), food habits and socio economic status were assessed using a questionnaire developed from the one previously used from the enKid study conducted on Spanish children. Food reported in the questionnaire was classified in four food groups (animal source food/legumes, grains/tubers, fruits/vegetables, fats/sweets), beverages were classified separately. Blood samples were analyzed to determine concentrations of: total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, glucose. Children were found to eat fats and sweets more frequently than other food groups. The 59 children, found to be obese and overweight, presented significant higher blood lipid levels (except to glucose levels) than normal weight kids. Using random forests, we found out that food and beverage consumption plays a key role in influencing blood lipids profile in children overweight and obese. Given these observations, it's crucial to develop health care policies promoting healthy eating habits among schoolchildren taking into account the specific characteristics of this geographical area in Mexico(AU)

Este estudio transversal tiene como objetivo investigar los hábitos alimentarios, el nivel socioeconómico y el perfil de lípidos sanguíneos en niños en edad escolar que viven en una zona de bajos recursos en México, caracterizando las concentraciones de lípidos en niños obesos/sobrepeso y evaluar el impacto de los factores socioeconómicos y hábitos dietéticos en el perfil de lípidos de estos niños. Mediante un cuestionario utilizado previamente en el estudio enKid realizado con niños españoles lo realizaron en forma completa 156 niños (78 niños y 78 niñas), se evaluó los hábitos alimentarios y el estado socioeconómico. Los alimentos reportados en el cuestionario se clasifica en cuatro grupos de alimentos (alimentos fuente animal / legumbres, granos / tubérculos, frutas / verduras, grasas / dulces), las bebidas fueron clasificadas por separado. Se analizaron muestras de sangre para determinar las concentraciones de: colesterol total, LDL-colesterol, HDL-colesterol, triglicéridos, glucosa. Los 59 niños, obesos/sobrepeso, presentaron niveles de lípidos en sangre significativamente más altos que los niños de peso normal. Usando Selvas Aleatorias nos enteramos de que los alimentos y el consumo de bebidas juegan un rol clave para influir en el perfil de lípidos en la sangre en niños obesos/sobrepeso. Teniendo en cuenta estas observaciones, es crucial desarrollar políticas de salud que promueven hábitos alimenticios saludables entre los escolares, teniendo en cuenta las características específicas de esta área geográfica en México(AU)

What is breakfast for Mexican children?

In order to face with the concerning rising prevalence of overweight and obesity in childhood, Mexican government has implemented Nutritional Indications (NI) for preschool and schoolchildren. The aim of our study is to investigate what Mexican children have for breakfast and if they meet NI, which recommends that daily breakfast should include one food from each of the three recommended food groups (grains and tubers, animal source food and legumes, fruits and vegetables). We considered a sample of 120 male children aged 3-14 years, their mothers were asked to complete a questionnaire and to fill a breakfast diary for one week. Food was grouped in the three recommended food groups and a further group including fats and sweets was considered. Only 32 children met NI at least once a week (compliant children) and nobody followed NI throughout the week. The analysis on breakfast records showed a low intake of the fruits and vegetables food group. Children were more likely to follow NI when they had breakfast with family members. We show that children do not meet breakfast's NI, but further researches are needed to investigate the long-term impact of NI on Mexican children eating patterns(AU)

Para hacer frente al aumento de la prevalencia de sobrepeso y obesidad en la infancia, el Gobierno Mexicano ha implementado las indicaciones nutricionales (IN) para niños en etapas preescolar y escolar. El objetivo de nuestro estudio es investigar los componentes del desayuno en la dieta de niños Mexicanos, además del cumplimiento con las IN, que recomiendan que el desayuno diario debe incluir un alimento de cada uno de los tres grupos alimenticios recomendados (granos y tubérculos, alimentos de origen animal, y legumbres, frutas y verduras). Se consideró una muestra de 120 niños (de género masculino) con edades entre 3 y 14 años. Se solicitó a sus madres completar un cuestionario y realizar un registro diario de los componentes del desayuno durante una semana. Los alimentos se agruparon según dictan las IN; además, un grupo que incluye grasas y dulces fue también considerado. Sólo 32 niños cumplieron con las IN al menos una vez a la semana (los niños que cumplen) y ninguno siguió las IN durante toda la semana. El análisis sobre los registros diarios mostró un bajo consumo del grupo de alimentos compuesto por frutas y verduras. El justo seguimiento de las IN ha sido más probable cuando el desayuno se ha realizado con miembros de la familia. Se demuestra que los niños no cumplen el IN del desayuno, pero se necesitan más investigaciones para investigar el impacto a largo plazo de IN sobre los hábitos alimenticios de los niños mexicanos(AU)

Research in Nursing and Nutrition: Is Randomized Clinical Trial the Actual Gold Standard?

The aim of this study was to assess the quality of reporting of nurse-driven randomized controlled trials involving a direct nutritional intervention. A bibliometric search for randomized controlled trials involving a direct nutritional intervention from 1991 to 2011 in nursing research was conducted. Both quality of the study and design aspects were evaluated. The prevalent randomized controlled trial design used is 2-arm parallel, individual, and randomized with a continuous primary endpoint. Global numbers of randomized controlled trials and the proportion of good-quality randomized controlled trials began a steady and marked rise, more than doubling, from the 1990s to about 2001 and increased slowly thereafter. Studies are overall sufficiently well designed, although there is still room for quality improvement. Additionally, implementation of new randomized controlled trial designs exists and should be advocated.

Physiologic Determinants of Left Atrial Longitudinal Strain: A Two-Dimensional Speckle-Tracking and Three-Dimensional Echocardiographic Study in Healthy Volunteers.

BACKGROUND: Left atrial (LA) longitudinal strain (LS) using two-dimensional speckle-tracking echocardiography has emerged as an important diagnostic and prognostic parameter in various cardiovascular conditions. However, its reference values, their correlations with demographics characteristics, and its physiologic determinants remain to be established. METHODS: Accordingly, 171 healthy volunteers (mean age, 45 ± 12 years; 61% women) in whom LS was obtained from both apical four- and two-chamber dedicated views of the left atrium, considering the P-P interval on the electrocardiogram as the reference cardiac cycle, were prospectively studied. From the LA LS curve we measured the extent of the negative deflection (LSneg), representing LA active contraction, the positive deflection (LSpos) during LA filling, and total LS (LStot), as the sum of LSneg and LSpos values. RESULTS: Average values for biplane LA LSpos, LSneg, and LStot were 19.7%, -14.5%, and 33.3%, respectively. On multivariate analysis, age, left ventricular (LV) global LS and volume, and LV diastolic function were the main physiologic determinants of LA LSpos (R2 = 0.57) and LStot (R2 = 0.40), whereas systolic blood pressure, E/A ratio, global LS, and LV stroke volume were the main determinants of LA LSneg (R2 = 0.20). Women had higher LSpos and LStot than men, particularly before 50 years of age. LA LSpos and LStot decreased with aging, with different trends in men and women. CONCLUSIONS: LA LS values are different in men and women and should be interpreted taking into account patient age and LV function as well. These reference values may help identify subclinical LA dysfunction in several cardiovascular or systemic conditions.

[Current practice and changing trends in the percutaneous treatment of structural heart disease. Results of a multicenter survey promoted by the Italian Society of Interventional Cardiology in six Italian Regions including Tuscany, Lombardy, Veneto, Emilia-Romagna, Campania and Puglia]. / Pratica clinica attuale e trend di variazione in cardiologia interventistica strutturale. Risultati di una survey multicentrica SICI-GISE in sei Regioni italiane: Toscana, Lombardia, Veneto, Emilia-Romagna, Campania e Puglia.

BACKGROUND: Significant developments have occurred in the field of percutaneous interventions for structural heart disease over the last decade. The introduction of several innovations has expanded significantly the spectrum of therapeutic applications of structural interventional cardiology. However, the translation of the most recent scientific evidence into clinical practice and the adoption of new technologies may be susceptible to large variability, even within the same geographic area. This study aimed at describing current status and changing trends of structural heart interventions within 6 Regions in Italy. METHODS: Between July 2015 and October 2015, 6 regional delegations of the Italian Society of Interventional Cardiology (SICI-GISE) promoted a web-based multicenter survey concerning structural heart interventions. An ad hoc questionnaire was administered to head physicians of the cath-labs of 4 Regions of Northern Italy (Tuscany, Lombardy, Veneto and Emilia-Romagna) and 2 Regions of Southern Italy (Puglia and Campania). Also, in this study we considered previous data from a similar survey that involved Tuscany, Lombardy, Veneto and Emilia-Romagna between April 2014 and May 2014. Data from the two surveys were compared, observing the changing trends between 2014 and 2015. RESULTS: The 2015 survey was completed in more than two thirds (68%) of the 145 eligible cath-labs. According to the survey, the application of percutaneous structural heart interventions and the availability of devices were wide and homogeneous within the 6 Regions involved. The main factors perceived as limiting the execution of structural heart interventions resulted economic (e.g. cost of procedures and devices) or organizational (e.g. limited diffusion of hybrid operating rooms). CONCLUSIONS: In this study, which was based on the results of a recent survey conducted in 6 Italian Regions, structural heart interventions resulted widely growing throughout the investigated area. The indications for treatment and the availability of devices were relatively homogeneous between the regions involved, as well as the limiting factors, which appear to be mainly economic-organizational.

Left Atrial Volumes and Function by Three-Dimensional Echocardiography: Reference Values, Accuracy, Reproducibility, and Comparison With Two-Dimensional Echocardiographic Measurements.

BACKGROUND: Our study sought to (1) identify reference values for left atrial (LA) volumes and phasic function indices by 3-dimensional echocardiography (3DE) and compare them with those measured by 2-dimensional echocardiography (2DE) and (2) analyze their relationship with age, sex, body size, and left ventricular function. Accuracy and reproducibility of 3DE and 2DE have been also tested to evaluate the robustness of our data. METHODS AND RESULTS: We obtained maximal, minimal, and preA LA volumes by 3DE and 2DE in 276 healthy volunteers (18-79 years; 57% women). Limits of normality for LA volumes and total LA emptying fraction were larger with 3DE than with 2DE (maximal LA volume: 43 versus 35 mL/m(2); preA LA volume: 31 versus 25 mL/m(2); minimal LA volume: 18 versus 14 mL/m(2); 53 versus 48%, respectively; P<0.001). 3DE LA volumes indexed by body surface area were similar in men and women and increased with age. On multivariable analysis, age, weight, and left ventricular systolic and diastolic function indices resulted as correlates of LA 3DE indices. LA volumes were tightly correlated with cardiac magnetic resonance measurements, yet more underestimated by 2DE versus 3DE (bias±SD: -17±16 versus -7±15 mL, respectively). Among all LA parameters, maximal LA volume and total emptying fraction were the most reproducible, including at test-retest and at expert versus trainee comparisons. CONCLUSIONS: This study provides reference values for LA 3DE volumes and function from a relatively large cohort of healthy subjects with a wide age range. Our data may help clinicians to identify LA remodeling and dysfunction.

Sex- and Method-Specific Reference Values for Right Ventricular Strain by 2-Dimensional Speckle-Tracking Echocardiography.

BACKGROUND: Despite the fact that assessment of right ventricular longitudinal strain (RVLS) carries important implications for patient diagnosis, prognosis, and treatment, its implementation in clinical settings has been hampered by the limited reference values and the lack of uniformity in software, method, and definition used for measuring RVLS. Accordingly, this study was designed to establish (1) the reference values for RVLS by 2-dimensional speckle-tracking echocardiography; and (2) their relationship with demographic, hemodynamic, and cardiac factors. METHODS AND RESULTS: In 276 healthy volunteers (55% women; age, 18-76 years), free wall and septum RVLS (6 segments) and free wall RVLS (3 segments) using both 6- and 3-segment regions of interest were obtained. Feasibility of 6-segment RVLS was 92%. Free wall RVLS from 3- versus 6-segment regions of interest had similar values, yet 6-segment region of interest was more feasible (86% versus 73%; P<0.001) and reproducible. Reference values (lower limits of normality) were as follows: 6-segment RVLS, -24.7±2.6% (-20.0%) for men and -26.7±3.1% (-20.3%) for women; 3-segment RVLS, -29.3±3.4% (-22.5%) for men and -31.6±4.0% (-23.3%) for women (P<0.001). Free wall RVLS was 5±2 strain units (%) larger in magnitude than 6-segment RVLS, 10±4% larger than septal RVLS, and 2±4% larger in women than in men (P<0.001). At multivariable analysis, age, sex, pulmonary systolic pressure, right atrial minimal volume, as well as right atrial and left ventricular longitudinal strain resulted as correlates of RVLS values. CONCLUSIONS: This is the largest study providing sex- and method-specific reference values for RVLS. Our data may foster the implementation of 2-dimensional speckle-tracking echocardiography-derived RV analysis in clinical practice.

Symptoms associated with button batteries injuries in children: An epidemiological review.

OBJECTIVES: To provide an epidemiological framework of symptoms related to Foreign Body (FB) injuries due to Button Battery (BB). METHODS: Data on BB ingestion/inhalation have been obtained from the ButtonBatteryDB. The ButtonBatteryDB is a database collecting information on BB injuries in children (0-18 years of age). Data on 348 BB injures have been derived from the Registry of Foreign Body Injuries "Susy Safe" (269 cases) and from published scientific literature reporting case reports of FB injuries (79 cases). RESULTS: Most of injured children were male and BBs were found more often in the mouth/esophagus/stomach (ICD935) and in the nose (ICD932). Analyzing symptoms related to BB located in the esophagus/mouth/stomach, we found that children had higher probability of experiencing dysphagia (30.19%, 95% C.I. 17.83-42.55), fever and cough (26.42%, 95% C.I. 14.55-38.28), compared to the other symptoms. Referring to the probability that symptoms occurred simultaneously, fever and cough are more likely (3.72%, 95% C.I. 1.0-6-43) to jointly showing up in children with BB in mouth/esophagus/stomach (ICD935), followed by fever and dysphagia (2.66%, 95% C.I. 0.36-4.96) and by fever and irritability/crying, fever and drooling, dysphagia and irritability/crying (2.13% C.I. 0.00-4.19, 95% C.I.) CONCLUSIONS: These findings provide new insight in clinical presentation of BB injuries: the identification of unique patterns of symptoms related to BB injuries is useful to perform an early diagnosis (and to guarantee a prompt medical reaction), also when the injury is un-witnessed.