[Experimental model of generalized herpetic infection in newborns]. / Eksperimental'naia model' generalizovannoi gerpeticheskoi infektsii novorozhdennykh.

Generalized herpetic infection (GI) with a predominant involvement of the brain, eye, liver and spleen, in which cell rhexis and hyperchromatosis and large necrotic foci were observed, has been experimentally reproduced in newborn rabbits. Administration of herpes simplex virus at the dose of 5LD50 resulted in the suppression of immune reactions and animal death 4-5 days later. Dose of 2LD50 resulted in the immune response in the lymphoid organs, but the signs of the disease disappeared 5 days after the injection of the virus. The hypothesis on the existence of several clinico-morphological variants of GI is postulated.

[Effect of weightlessness on the indices of brain development (the results of pregnant rats being on the Kosmos-1514 biosatellite and research on the subsequent development of their progeny on Earth)]. / Vliianie nevesomosti na nekotorye pokazateli razvitiia golovnogo mozga (rezul'taty prebyvaniia beremennykh krys na biosputnike "Kosmos-1514" i issledovanie posleduiushchego razvitiia ikh potomstva na Zemle).

Beginning from the 13th day of pregnancy the rats were under conditions of weightlessness of spaceflight for 6 days. After landing in 18-day-old fetuses the state of their brain development is investigated comparing to that in control animals, that are on the Earth. As demonstrates analysis of a number of morphological processes: reproduction, migration, neuronal differentiation, growth of processes, establishment of nervous connections, neuroglial interconnections and vascularization--all they under conditions of weightlessness develop rather fully. Certain deviations in vascularization (as examples the medulla oblongata and the striated tuber are taken) are observed--the amount of vessels is greater and they are thinner--and changes in migration rate of cells is demonstrated by the example of the cortical plate formation. These changes are quickly levelled during their subsequent development on the Earth.

[Histochemical study of the chemoreceptor function of the carotid body in comparison with the superior cervical ganglion]. / Gistokhimicheskoe issledovanie khemoretseptornoi funktsii karotidnogo tel'tsa v sravnenii s verkhnim sheinym gangliem.

The distribution and relative activities of some dehydrogenases and diaphorases in the rat's carotid body and ganglion cervicale superior were studied histochemically and cytophotometrically. The treatment of rats by the medium with decreased oxygen and increased carbon dioxide contents, a reliable rise of NAD--diaphorase activities was found in the interlobe tissue and (less expressed and late appearing) in the principal cells. In contrast, such changes were not observed in the ganglion cervicale superioir, that have not a special chemoreceptory function. It is supposed that these changes in enzyme activities in the carotid body is due to the chemoreceptory function of the intralobe tissue containing the IInd type cells and "special" cells of sensitive nerve terminals.

[The pathogenesis of psychomotor epilepsy (a histochemical study of a penicillin epileptic focus in the rat hippocampus)]. / K patogenezu psikhomotornoi épilepsii (gistokhimicheskoe issledovanie penitsillinovogo ochaga v gippokampe krys)

By the aid of histochemical methods the authors sutdied the activity and distribution of acetylcholinesterase, monoamineoxidase, glutamatedehydrogynase and gammaaminobutyric acid -- transferase in the dorsal hypocampus of rats. It was shown that the activity of all the studied enzymes are significantly changed following 0.5 and 1.5 hours and are restituted following 48 hours after the formation of a pathological focus. It is concluded that a drop in the activity of glutamatedehydrogenase and gammaaminobutyric acid may be directed toward an accumulation of gammaaminobutyric acid in the epileptogenic focus and an inhibition of its activity. A drop in the histochemical reaction to acetylcholinesterase may indicate a decrease in the functions of the cholinergic systems with an active epileptogenic focus in the hypocampus.