ABSTRACT
UNLABELLED: The aim of the study was to investigate the therapeutic opportunities of S-adenosylmethionine and polyunsaturated lecithin in Child class A patients with alcoholic liver cirrhosis using transient elastography. MATERIALS: The 38 males Child class A alcoholic liver cirrhosis were investigated. RESULTS: The use of S-adenosylmethionine or polyunsaturated lecithin in patients with alcoholic liver cirrhosis is reasonable cause of their possibility to reduce the fibrogenesis in liver tissue and of their possibility to improve the function of remained intact hepatocytes. Thus use of this remedies prevents progression of cirrhotic transformation of the liver and gives a patient an opportunity to get the stable clinical status.
Subject(s)
Hepatocytes/pathology , Lecithins/administration & dosage , Liver Cirrhosis, Alcoholic/drug therapy , Liver Cirrhosis, Alcoholic/pathology , Liver/pathology , S-Adenosylmethionine/administration & dosage , Adult , Hepatocytes/metabolism , Humans , Liver/metabolism , Liver Cirrhosis, Alcoholic/metabolism , MaleABSTRACT
The objective of the present study was to analyse cases of intoxication with opioid narcotics at different blood morphine levels, from low and very low (below 0.5 mg/l) to regular toxic ones (1-4 mg/I). It was shown that molecular genetic studies at postmortem morphine concentrations of up to 0.5 mg/l as a rule identify mutant alleles (CYP2D6*3*4; CYP2C19*2*3). Mutant alleles CYP2D6* and CYP2C19* are most frequently detected at postmortem blood morphine levels ranging from 1 to 4 mg/I. These findings make it possible to regard death cases at low morphine concentrations as due to genetic susceptibility to different morphine derivatives (heroin, morphine hydrochloride). The remaining subjects lacking mutations in CYP2D6 and CYP2C19 genes are considered to be ordinary metabolizers dying at toxic concentrations of morphine in their blood (from 1 to 4 mg/I); such cases need no genetic studies to be carried out to identify CYP2D6 and CYP2C19 polymorphism.