[COMPASS study results as a foundation for new treatment approach for neurological patients. Opinion of the expert council of december 18, 2021]. / Znachenie rezul'tatov issledovaniya COMPASS v izmenenii podkhodov k lecheniyu patsientov nevrologicheskogo profilya. Zaklyuchenie soveta ekspertov ot 18 dekabrya 2021 g.

The resolution of the Council of Experts devoted to the discussion of the effectiveness of the use of a combination of rivaroxaban 2.5 mg 2 times a day and acetylsalicylic acid 100 mg per day to prevent recurrent non-coronary ischemic stroke results of the COMPASS study is presented. The advantages of this combination and the safety of its use are considered. Recommendations for the implementation of the results of the study in clinical practice are given.

[The method of quantitative assessment of rehabilitation in patients with cerebral stroke].

We have designed a new Self-Service scale for assessing patients with cerebral stroke. This scale enables to determine the degree of patients' self-servicing in everyday life, his/her social activity, mobility, memory and speech. It was administered to 59 patients (33 men and 26 women) aged from 35 to 79 years at admission to and discharge from the hospital. Assessment of a specialist has been compared to that of an expert by all subscales and by cumulative index of the Scale as well as to the results of other psychometric scales used in clinical practice. The results revealed the high construction and criterion validity, both current and prognostic, and high reliability of the scale.

[Efficacy of OSMO-Adalat in patients with arterial hypertension in combination with kinked precerebral arteries]. / Effektivnost' lecheniia OSMO-Adalat bol'nykh arterial'noi gipertoniei v sochetanii s patologicheskoi izvitost'iu pretserebral'nykh arterii]

AIM: To evaluate effectiveness of OSMO-adalat in combination of arterial hypertension (AH) with kinked precerebral arteries (KPA). MATERIAL AND METHODS: Before and after a 3-month course of OSMO-Adalat in a dose 30 and 60 mg, 28 patients with AH (degree 2-3) and KPA were examined for arterial pressure (AP), dyscirculatory encephalopathy, orthostatic stability, ischemic heart disease, transitory ischemic attacks, side effects of therapy. RESULTS: A complete normalization of AP was achieved in 9(32.1%) patients, in the rest patients the effect was partial. 24-h AP profile improved in all the cases. OSMO-Adalt relieved coronary insufficiency and dyscirculatory encephalopathy, improved tolerance of orthostatic loads. Syncopes, transitory ischemic attacks and strokes were not observed. Severe head ache was the cause of the treatment discontinuation in one patient. CONCLUSIONS: Therapy with OSMO-Adalat of patients with AH combination with KPA provides a good hypotensive effect and relieves symptoms of encephalopathy, myocardial ischemia and orthostatic insufficiency in low risk of side effects.

[Aspects of ischemic stroke course in patients with heart-related embolism]. / Osobennosti techeniia ishemicheskogo insul'ta u patsientov s kardiogennym istochnikom émbolii.

193 patients with acute ischemic hemispheric stroke were examined. We divided them into two groups. Group 1 included patients with cardiac embolism (n = 49), patients without embolisms (n = 144) formed Group 2. We revealed that patients of Group 1 were significantly older and had severe neurologic deficit and higher mortality. The size of ischemic foci assessed by computed tomography were larger, and the disturbances of cerebral blood flow estimated by transcranial Doppler ultrasonography were more severe in Group 1. The reason to be supposed may be a larger size and pattern of cardiac emboli.

[Autoantibodies to NMDA-type glutamate receptors in the blood of patients with acute ischemic and hemorrhagic stroke]. / Autoantitela k glutamatnym retseptoram NMDA-tipa v krovi patsientov s ostrym ishemicheskim i gemorragicheskim insul'tom.

The characteristics of accumulation of autoantibodies (aAbs) on NMDA-type glutamate receptors were studied in blood of patients at different stages (1-4 days, 5-7 days, 8-14 days, up to 28 days) of acute period of ischemic or hemorrhagic stroke. The stability of low values (1.29 +/- 0.31 ng/ml) of the titer of aAbs to NMDA-receptors was revealed in patients with acute cerebral hemorrhage. Two types of titer of Abs to NMDA-receptors were revealed in case with cerebral ischemia. The undulating nature of Abs titer changes was revealed in acute ischemic strokes caused by hypertension and cerebral atherosclerosis (from 2.23 +/- 0.53 ng/ml on the 1-st day with increase up to 3.23 +/- 0.90 ng/ml and up to the 3-4 day), following fluctuations with less pronounced increase on 7-8th day were found out. High titer of aAbs to NMDA-receptors (up to 10.0 ng/ml) were observed on 3-4th day in cases of acute ischemic strokes on the background of chronic alcohol encephalopathy caused by intoxication or dysmetabolism with their retention up to 10-14th day.

[Age-related dynamics of energy metabolism enzymes of neurons and microvessels of the brain in spontaneously hypertensive rats]. / Vozrastnaia dinamika fermentov énergeticheskogo metabolizma neironov i mikrososudov golovnogo mozga spontanno gipertenzivnykh krys.

The age changes in the activity of some enzymes in neurons and in microvessels, revealed histochemically, as well as the volume of microvessels in spontaneously hypertensive (SH) rats differ from these changes in the controls. At the age of 3 months the activity of these enzymes and the number of active microvessels in SH rats increased. At the age of 6 months the activity of studied enzymes in SH rats decreased, while the number of active microvessels remained constant. The correlation between the morpho-functional characteristics of brain tissue in SH rats and its greater ischemic vulnerability is assumed.

[Study of prevalence and structure of cerebrovascular disorders in different regions of the USSR based on simultaneous epidemiological examinations]. / Rasprostranennost' i struktura tserebrovaskuliarnykh zabolevanii v razlichnykh regionakh SSSR po dannym adnomomentnogo épidemio- logicheskogo issledovaniia.

The authors describe the data of the screenings of the representative random samples from the open male population aged 20 to 54 years, carried out in accordance with the common program in 6 cities of this country. The prevalence of definite cases of cerebrovascular diseases (CVD) ranged from 7.7% in Moscow to 12% in Irkutsk. As to the structure of cerebrovascular injuries, the initial manifestations of brain blood supply insufficiency accounted for 68%. The prevalence of CVD turned out to be the greatest in Western Siberia, the least in the European region. The transcaucasian republics occupy an intermediate position.

Intraspecies behavior of animals based on a model of experimental brain ischemia.

The features of the intraspecies behavior of rats after ligation of the right, left, or both common carotid arteries were studied. It was shown that certain characteristics of behavior change differently following ligation of the right or left common carotid artery. The approach used may be utilized for the assessment of the severity of ischemic brain damage.

[Intraspecies animal behavior in a model of experimental cerebral ischemia]. / Vnutrividovoe povedenie zhivotnykh na modeli éksperimental'noi ishemii mozga.

Specifics of intraspecies behaviour following ligation of both or either one of the two carotid arteries, were studied in rats. Certain behavioural features are altered in different ways depending on ligation of the right or left carotid artery. The approach can be applied to evaluation of graveness of the brain ischemic lesion.

[Characteristics of the morphofunctional status of the tissue in the rat cerebral cortex in experimental renal arterial hypertension]. / Osobennosti morfofunktsional'nogo sostoianiia tkani kory golovnogo mozga krys pri éksperimental'noi pochechnoi arterial'noi gipertenzii.

Activity of some enzymes in the cerebral cortex of rats with experimentally induced renal arterial hypertension (AH) was studied histochemically. Histologic data provide the evidence for the disturbances in water-salt metabolism in AH. Morphometric study revealed an increase in the specific volume of smaller microvessels and moderate decrease in the specific volume of bigger microvessels. Vascular markers show different time course of activity changes in AH: the activity of alkaline phosphatase increases, while that of alpha-glycerophosphate dehydrogenase remains unchanged. The development of AH is accompanied by the increase in succinic dehydrogenase activity and the decrease in the activity of lactate dehydrogenase in neurons. The changes in the neuron-capillary relationship arising in AH can be one of the possible pathogenetic factors in the pathologic process progression.

[Dynamics of local brain blood flow in experimental ischemic stroke]. / Dinamika lokal'nogo mozgovogo krovotoka pri éksperimental'nom ishemicheskom insul'te.

The changes in the local cortical blood flow in different areas of the large hemispheres were examined in cats at varying times after cerebral ischemia. It was shown that the decreased blood flow (after occlusion of the cerebral artery) in one of the brain areas is accompanied by various changes in different parts of the large hemispheres.