ABSTRACT
Noninvasive B72.3 monoclonal antibody imaging provides beneficial information that may influence therapeutic and surgical decisions, and may clarify other clinical, laboratory, and CT scan findings. Intraoperative localization of tumor sites with a hand-held gamma probe holds promise as a further advantage of this technique.
Subject(s)
Biomarkers, Tumor/blood , Colorectal Neoplasms/diagnosis , Genital Neoplasms, Female/diagnosis , Radioimmunodetection , Tomography, X-Ray Computed , Aged , CA-125 Antigen/blood , Colorectal Neoplasms/diagnostic imaging , Female , Genital Neoplasms, Female/diagnostic imaging , Humans , Sensitivity and SpecificityABSTRACT
Gallium imaging offers many practical advantages over indium-111-labeled leukocyte imaging, and calculating quantitative ratios in addition to performing the routine bone-gallium images allows accurate and easy evaluation of patients with suspected osteomyelitis. To add objectivity and improve the accuracy and confidence in diagnosis of osteomyelitis, quantitative comparison of abnormalities seen on bone scans and gallium scans was performed. One hundred and ten adult patients with 126 sites of suspected osteomyelitis were evaluated and categorized by gallium-to-bone ratios, gallium-to-background ratios, and spatial incongruency of gallium and bone activity. Combined evaluation using these criteria gave a 70% sensitivity and 93% specificity for the diagnosis of osteomyelitis.
