1.
Open Forum Infect Dis
; 6(7)2019 Jul 01.
Article
in English
| MEDLINE
| ID: mdl-31363765
ABSTRACT
To evaluate potential enhancement of Zika virus (ZIKV) infection among patients with prior dengue virus (DENV) infection, we compared loads of viral RNA among patients infected with ZIKV (n = 1070), DENV-2 (n = 312), or DENV-3 (n = 260). Compared to patients without prior DENV infection, patients with prior DENV infection had significantly higher mean loads of viral RNA if infected with DENV-2 (10.6 vs 11.6 log10 GCE/mL, respectively; t test, P < .0001) or DENV-3 (10.3 vs 10.9 log10 GCE/mL; P < .0001), but not ZIKV (4.7 vs 4.7 log10 GCE/mL; P = .959). These findings provide evidence against in vivo enhancement of ZIKV by anti-DENV antibodies.
2.
San Juan, P.R; U.P.R., R.C.M., Escuela de Medicina, Departamento de Microbiolog¡a; 2009. ix, 84 p gr ficas, tablas.
Thesis
| Puerto Rico
| ID: por-50450