ABSTRACT
A woman with clinical manifestations of progressive systemic sclerosis had liver disease with histologic and immunologic features of primary biliary cirrhosis. Biopsy specimens of salivary gland showed necrosis and lymphocytic infiltrates in and around ducts similar to those observed in hepatic ducts, whereas neither of these tissues exhibited immunoglobulin or complement deposition. The ultrastructural and immunohistochemical studies suggest a common cell-mediated immunologic mechanism for the two disorders.
Subject(s)
Liver Cirrhosis, Biliary/complications , Scleroderma, Systemic/complications , Female , Humans , Immunoglobulin A/analysis , Immunoglobulin E/analysis , Immunoglobulin G/analysis , Jejunum/pathology , Liver/pathology , Liver Cirrhosis, Biliary/immunology , Liver Cirrhosis, Biliary/pathology , Middle Aged , Salivary Glands, Minor/pathology , Scleroderma, Systemic/immunology , Scleroderma, Systemic/pathology , Skin/pathologyABSTRACT
Significant hepatotoxicity due to allopurinol seems to be rare. Only 6 such cases have been recorded in the literature. The clinical and histopathologic findings of allopurinol-induced liver injury are variable in the previously reported cases. Described herein is another patient with allopurinol hepatotoxicity. Of interest is the similar histopathology between the present case and the two previously reported cases of allopurinol-induced granulomatous hepatitis; thus this is the third such recorded case. Allopurinol should be suspected when liver abnormalities occur following use of this drug.
Subject(s)
Allopurinol/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Adult , Allopurinol/therapeutic use , Arthritis/drug therapy , Biopsy , Chemical and Drug Induced Liver Injury/pathology , Gout/drug therapy , Humans , Liver/pathology , Liver Function Tests , MaleABSTRACT
A 76-year-old man presented with hypoglycemic coma associated with metastatic liver disease. Serum immunoreactive insulin excluded insulinoma as a cause of hypoglycemia. Negative glucose responses to glucagon and epinephrine testing indicated failure of compensatory glycogenolysis. The patient's increased glucose requirements of 500 g per 24 hr were reduced to normal only after shrinkage of the liver tumor bulk was accomplished with chemotherapy. Hepatic hypoglycemia is discussed and the literature is reviewed.
Subject(s)
Hypoglycemia/etiology , Liver Neoplasms/complications , Aged , Cyclophosphamide/therapeutic use , Fluorouracil/therapeutic use , Humans , Liver Neoplasms/drug therapy , Male , Neoplasm Metastasis , Prostatic Neoplasms/pathologyABSTRACT
Nine out of twelve obese patients (75%) demonstrated diminished minute ventilation volume (MVV) prior to jejunoileal bypass surgery. Seven out of the nine patients (78%) showed improvement in the MVV as weight reduction ensued following surgery. Other parameters, including arterial blood gases, did not change after weight loss. Weight reduction as a result of jejunoileal bypass surgery brings about an improvement in pulmonary function.
Subject(s)
Ileum/surgery , Jejunum/surgery , Obesity/surgery , Respiratory Function Tests , Adult , Body Weight , Female , Forced Expiratory Volume , Humans , Hypoventilation/etiology , Lung Volume Measurements , Male , Middle Aged , Obesity/complications , Smoking/complications , Time FactorsABSTRACT
The effect of oral glucose, fructose and sucrose on the disappearance rate for intravenously administered alcohol was studied in eight abstinent alcoholic subjects. The three sugars were ingested on separate days in random sequence. alcohol levels were determined at hourly intervals. During sugar ingestion, the mean rates of alcohol disappearance were: 19 plus or minus 1.4 mg/100 ml per hour (plus or minus SE), with glucose, 23.9 or minus 1.4 mg/100 ml per hour with sucrose, and 25.4 plus or minus 1.4 mg/100 ml per hour with fructose. Compared to glucose both fructose and sucrose increased the rate of alcohol from the blood. The blood levels of fructose were similar after the oral dose of 2 g/kg of fructose or 4 g/kg of sucrose.
