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Eur J Pediatr ; 156(2): 90-3, 1997 Feb.
Article in English | MEDLINE | ID: mdl-9039508

ABSTRACT

UNLABELLED: The effectiveness of systemic corticosteroids in erythema multiforme major (EMM) is controversial. We therefore evaluated the efficacy of corticosteroids in the treatment of EMM in a prospective study of 16 children with EMM admitted to our department within 3 days from the onset of rash. Ten patients (group A) received bolus infusions of methylprednisolone (4 mg/kg/day) while six had only supportive treatment (group B). The early use of corticosteroids compared to supportive treatment resulted in: (1) significant reduction of the period of fever (4.0 +/- 1.9 vs 9.5 +/- 4.2 days P = 0.01); (2) reduction of the period of acute eruption (7.0 +/- 3.3 versus 9.8 +/- 3.0 days P = 0.08); and (3) milder signs of prostration. Complications were minimal in both groups. CONCLUSION: The early and short course of corticosteroids favourably influences the course of erythema multiforme major in children.


Subject(s)
Glucocorticoids/therapeutic use , Methylprednisolone/therapeutic use , Stevens-Johnson Syndrome/drug therapy , Adolescent , Child , Child, Preschool , Female , Humans , Male , Prospective Studies , Stevens-Johnson Syndrome/physiopathology
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