[Secretin and pancreatic secretion in iron absorption]. / Secretina y secreción pancreática en la absorción de hierro.

Iron absorption in dogs without pancreatic secretion was studied measuring the percentage of radioactivity retained in red cells. Two groups were treated con 59Fe (5 microCi), given in the stomach: one group control and other undergoing pancreatic duct ligation. Increased absorption was observed in the last group. The influence of secretion on iron absorption, after administration of 60 mg of Fe (as ferrous sulphate solution pH 4.5), was also studied in three groups of dogs, treated with 18 Clinical Units of secretin. In one group, the pancreatic secretion was extracted from intestine by putting a catheter in the pancreatic duct. In the other two, the pancreatic duct remained normal, one with and other without the iron dose (control). A possible inhibitory effect of secretin on iron absorption was observed. Plasma Iron values remained without changes one hour after the iron administration, as well as TIBC, % saturation and transferrin values.

Secretina y secreción pancreática en la absorción de hierro. / [Secretin and pancreatic secretion in iron absorption]

Iron absorption in dogs without pancreatic secretion was studied measuring the percentage of radioactivity retained in red cells. Two groups were treated con 59Fe (5 microCi), given in the stomach: one group control and other undergoing pancreatic duct ligation. Increased absorption was observed in the last group. The influence of secretion on iron absorption, after administration of 60 mg of Fe (as ferrous sulphate solution pH 4.5), was also studied in three groups of dogs, treated with 18 Clinical Units of secretin. In one group, the pancreatic secretion was extracted from intestine by putting a catheter in the pancreatic duct. In the other two, the pancreatic duct remained normal, one with and other without the iron dose (control). A possible inhibitory effect of secretin on iron absorption was observed. Plasma Iron values remained without changes one hour after the iron administration, as well as TIBC,

saturation and transferrin values.

[Variation of serum zinc after iron administration to dogs under pancreatic duct ligation (author's transl)]. / Variación del cinc sérico después de la administración de hierro en perros con conductos pancreáticos ligados.

Variations of serum zinc and copper in relation with iron absorption, in a group of dogs undergoing pancreatic duct ligation, have been studied. Mean plasma iron concentrations, total serum zinc and copper were determined after administration of an iron dose (60 mg FeSO4 . 4H2O, pH 4). Significant increase of serum zinc and plasma iron was observed. In copper experiments no significant results were found.

[Plasma proteins in iron transport]. / Proteinas plasmáticas en el transporte del hierro.

This study deals with the effects of iron overloading on total iron-binding capacity TIBC) in fasting subjects. Overloading was obtained by oral administration of 198 mg. ferrous gluconate. The method of Bothwell and Mallet was used for plasma iron determination; the Mg CO3 methods was used for TIBC. It was that normal subjects as well as hyperthyroid, hypothyroid goiter patients showed an increase of TIBC under these conditions. These results could be explained either on the basis of functional heterogeneity of transferrin bound iron, or of a new protein.