1.
Bioorg Med Chem Lett
; 16(9): 2528-31, 2006 May 01.
Article
in English
| MEDLINE
| ID: mdl-16464579
ABSTRACT
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
Subject(s)
Coumarins/pharmacology , Enzyme Inhibitors/pharmacology , Lipoxygenase Inhibitors , Coumarins/chemical synthesis , Coumarins/chemistry , Enzyme Inhibitors/chemical synthesis , Enzyme Inhibitors/chemistry , Humans , Molecular Structure , Structure-Activity Relationship
2.
Arch. invest. méd
; 21(2): 175-7, abr.-jun. 1990.
Article
in English
| LILACS
| ID: lil-177281
