ABSTRACT
The effect of the malnutrition during suckling on the aggressiveness was investigated in adult rats treated or not with citalopram, a selective serotonin reuptake inhibitor (SSRI). The animals were divided into two groups according to the diet used: nourished group - the rats received the control diet with 23% protein during the life; and malnourished group - the rats had its mothers submitted to diet with 7.8% protein during suckling. At 120 days of age, each group was sub-divided according to the treatment: acute - consisting a single i.p. injection of saline solution or 20-mg/Kg citalopram; chronic - consisting the single injections (1 per day during 14 days) of saline or 20 mg/Kg citalopram. The acute or chronic treatment with SSRI reduces aggressive response in nourished rats, but not in malnourished ones. Thus, the malnutrition during the critical period of brain development seems to induce durable alterations in the function of the serotoninergic neurotransmission
Subject(s)
Aggression/drug effects , Behavior, Animal/drug effects , Citalopram/pharmacology , Nutrition Disorders/complications , Selective Serotonin Reuptake Inhibitors/pharmacology , Animals , Animals, Suckling , Body Weight , Brain/growth & development , Diet , Female , Lactation , Male , Nutrition Disorders/metabolism , Rats , Rats, WistarSubject(s)
Bipolar Disorder/genetics , Carrier Proteins/genetics , Depression/genetics , Dysthymic Disorder/genetics , Membrane Glycoproteins/genetics , Membrane Transport Proteins , Nerve Tissue Proteins , Polymorphism, Genetic , Adult , Brazil , Case-Control Studies , Genotype , Humans , Middle Aged , Serotonin Plasma Membrane Transport ProteinsABSTRACT
Uma revisao da literatura sobre as modificacoes bioquimicas induzidas pelos sais de litio, nao permitem uma explicacao univoca para o seu mecanismo de acao. Os numerosos estudos realizados em animais produzem resultados muitas vezes contraditorios. A evolucao do conhecimento, apesar de consideravel abre mais questoes do que fecha
Subject(s)
Lithium , Neurotransmitter AgentsABSTRACT
O nivel atual do conhecimento sobre os mecanismos de acao dos neurolepticos destaca a hipotese do bloqueio dos receptores dopaminergicos pre e pos-sinapticos, respectivamente inibidores e ativadores desse sistema. Trabalhos recentes demonstram que determinados grupos de neurolepticos apresentam afinidades distintas, tanto com relacao aos receptores quanto as vias especificas do sistema dopaminergico.Estima-se que a transmissao dopaminergica desempenha um papel importante em certos sintomas esquizofrenicos "produtivos" e "deficitarios". Propoe-se, dessa forma, alguns argumentos de base bioquimica para a utilizacao clinica dos neurolepticos
