1.
Vaccine
; 29(6): 1123-5, 2011 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-21172376
ABSTRACT
Intramuscular vaccination may lead to loss of subcutaneous fat resulting in skin depression at the site of injection. We report for the first time a delayed lipoatrophy after with AS03-adjuvanted influenza A (H1N1) 2009 vaccine. Inadequate administration into the adipose tissue may be causative. During next pandemic, education to optimal intramuscular administration and prolonged monitoring of adverse effects could be proposed.
Subject(s)
Influenza A Virus, H1N1 Subtype/immunology , Influenza Vaccines/adverse effects , Lipodystrophy/chemically induced , Polysorbates/adverse effects , Skin Diseases/chemically induced , Squalene/adverse effects , alpha-Tocopherol/adverse effects , Adult , Drug Combinations , Female , Humans , Influenza Vaccines/administration & dosage , Injections, Intramuscular , Lipodystrophy/pathology , Polysorbates/administration & dosage , Skin Diseases/pathology , Squalene/administration & dosage , Subcutaneous Tissue/pathology , alpha-Tocopherol/administration & dosage
2.
Presse Med
; 39(10): 1112-3, 2010 Oct.
Article
in French
| MEDLINE
| ID: mdl-20462734
