Subject(s)
Bipolar Disorder/therapy , Deep Brain Stimulation/adverse effects , Nucleus Accumbens , Obsessive-Compulsive Disorder/therapy , Panic Disorder/etiology , Adult , Bipolar Disorder/psychology , Humans , Magnetic Resonance Imaging , Male , Obsessive-Compulsive Disorder/psychology , Panic Disorder/diagnosisSubject(s)
Adult , Humans , Male , Bipolar Disorder/therapy , Deep Brain Stimulation/adverse effects , Nucleus Accumbens , Obsessive-Compulsive Disorder/therapy , Panic Disorder/etiology , Bipolar Disorder/psychology , Magnetic Resonance Imaging , Obsessive-Compulsive Disorder/psychology , Panic Disorder/diagnosisABSTRACT
BACKGROUND: Cognitive-behavioral group therapy (CBGT) and serotonin reuptake inhibitors have proven efficacy in reducing symptoms of obsessive-compulsive disorder (OCD). There is no consensus about which of these forms of treatment is more effective. This study was conducted to evaluate the efficacy of CBGT as compared to that of sertraline in reducing OCD symptoms. METHOD: Fifty-six outpatients with an OCD diagnosis, according to DSM-IV criteria, participated in the randomized clinical trial: 28 took 100 mg/day of sertraline and 28 underwent CBGT for 12 weeks. Efficacy of treatments was rated according to the reduction in scores on the Yale-Brown Obsessive Compulsive Scale (YBOCS) and the Clinical Global Impressions-Severity of Illness scale. The trial was performed in 4 successive periods from March 2002 to December 2003. RESULTS: Both treatments were effective, although patients treated with CBGT obtained a mean YBOCS reduction of symptoms of 44%, while those treated with sertraline obtained only a 28% reduction (p = .033). Cognitive-behavioral group therapy was also significantly more effective in reducing the intensity of compulsions (p = .030). Further, 8 patients (32%) treated with CBGT presented a complete remission of OCD symptoms (YBOCS score < or = 8) as compared to only 1 patient (4%) among those who received sertraline (p = .023). CONCLUSION: Cognitive-behavioral group therapy and sertraline have shown to be effective in reducing OCD symptoms. Nevertheless, the rate of symptom reduction, intensity reduction of compulsions, and percentage of patients who obtained full remission were significantly higher in patients treated with CBGT.
Subject(s)
Cognitive Behavioral Therapy , Obsessive-Compulsive Disorder/drug therapy , Obsessive-Compulsive Disorder/therapy , Psychotherapy, Group , Selective Serotonin Reuptake Inhibitors/therapeutic use , Sertraline/therapeutic use , Adult , Ambulatory Care , Female , Humans , Male , Obsessive-Compulsive Disorder/diagnosis , Psychiatric Status Rating Scales/statistics & numerical data , Quality of Life , Severity of Illness Index , Treatment OutcomeABSTRACT
Objective: To develop a cognitive-behavioral group therapy protocol and to verify its efficacy to reduce obsessive-compulsive symptoms. Methods: An open clinical trial with 32 obsessive-compulsive patients was performed, in which a cognitive-behavioral group therapy protocol of 12 weekly sessions of two hours, in 5 consecutive groups, was applied. The severity of symptoms was rated with the Yale-Brown Obsessive-Compulsive (Y-BOCS), Hamilton Anxiety (HAM A) and Hamilton Depression (HAM D) scales. The patients were followed up for 3 months after the end of the treatment. Results: There was a significant reduction in the scores of Y-BOCS, HAM A and HAM D scales with the treatment regardless the use of anti-obsessive medications. The rate of improved patients (decrease of > or = 35 percent in Y-BOCS) was 78.1 percent. Two patients (6.25 percent) dropped out from the study. The effect size calculated for the Y-BOCS scale was 1.75. Conclusions: This study suggests that cognitive-behavioral group therapy reduces obsessive-compulsive symptoms. In addition, patients presented good compliance
ABSTRACT
O número de indicações para a realização de fibrobroncoscopia vêm aumentando em nosso meio. Como as instituições que recebem a maior demanda de indicações para uso deste procedimento são os hospitais universitários, objetivou-se uma avaliação do procedimento e da população submetida ao exame no Hospital de Clínicas de Porto Alegre...
