Bayesian adaptive selection of basis functions for functional data representation.

Considering the context of functional data analysis, we developed and applied a new Bayesian approach via the Gibbs sampler to select basis functions for a finite representation of functional data. The proposed methodology uses Bernoulli latent variables to assign zero to some of the basis function coefficients with a positive probability. This procedure allows for an adaptive basis selection since it can determine the number of bases and which ones should be selected to represent functional data. Moreover, the proposed procedure measures the uncertainty of the selection process and can be applied to multiple curves simultaneously. The methodology developed can deal with observed curves that may differ due to experimental error and random individual differences between subjects, which one can observe in a real dataset application involving daily numbers of COVID-19 cases in Brazil. Simulation studies show the main properties of the proposed method, such as its accuracy in estimating the coefficients and the strength of the procedure to find the true set of basis functions. Despite having been developed in the context of functional data analysis, we also compared the proposed model via simulation with the well-established LASSO and Bayesian LASSO, which are methods developed for non-functional data.

Evaluation of chest computed tomography alterations of patients hospitalized by Covid-19 / Avaliação de alterações em tomografia computadorizada de tórax de pacientes internados por Covid-19

Introduction: SARS-CoV-2 has rapid dissemination and high infectivity and can evolve into Severe Respiratory Distress Syndrome (SARS), which led to a high number of deaths and hospitalizations in the recent pandemic. Computed tomography (CT) of the chest has demonstrated an essential role in the initial evaluation and evolution of these patients. Methodology: This was a retrospective observational study at a single center, University Hospital in Northeastern Brazil, evaluating 97 patients hospitalized for COVID-19 with laboratory confirmation to evaluate and quantify the chest CT findings, comparing the findings with the severity of the case and relating them to the morbidities presented. The CT scans were performed by radiologists from the hospital and the data were evaluated by the university's statistics laboratory. Results: Among the main alterations, ground-glass opacities were present in more than 90% of the patients. The study observed that the magnitude of the pulmonary involvement of this finding had a relationship with the outcome of higher hospitalization. Conclusion: In this sense, the relevance of chest CT to suggest the diagnosis of Covid-19 and establish the prognosis of the disease is observed. However, further studies are still needed to confirm these finding (AU).

Introdução: O SARS-CoV-2 possui rápida disseminação e alta infectividade, podendo evoluir com Síndrome da Angústia Respiratória Grave (SARS), o que levou a um número elevado de mortes e internações na recente pandemia. A Tomografia Computadorizada (TC) de tórax demonstrou um papel essencial na avaliação inicial e evolução desses pacientes. Metodologia: Este foi um estudo observacional retrospectivo em centro único - Hospital Universitário no Nordeste do Brasil - avaliando 97 pacientes internados por COVID-19 com confirmação laboratorial, a fim de avaliar e quantificar os achados de TC de tórax, comparando os achados com a gravidade do caso e relacionando-os com as morbidades apresentadas. As TCs foram laudadas por radiologistas do próprio hospital. Após isso, os dados foram avaliados pelo laboratório de estatística da universidade para serem analisados e discutidos. Resultados: Dentre as principais alterações, o vidro fosco estava presente em mais de 90% dos pacientes. Foi observado que a magnitude do comprometimento pulmonar deste achado apresentou relação desfavorável com o desfecho da internação. Conclusão: Neste sentido, observa-se a relevância da TC de tórax para sugerir o diagnóstico de Covid-19 e estabelecer o prognóstico da doença. No entanto, ainda são necessários mais estudos para destrinchar estes achado (AU).

Analysis of pulmonary function in post-Covid-19 patients at a university hospital / Análise da função pulmonar de pacientes com síndrome pós-covid-19 em um hospital universitário

Objective: Evaluate the spirometry pattern of patients who persisted with respiratory symptoms after infection with SARS-Cov-2. Methods: Cross-sectional, observational, retrospective study in a single center, approved by the local Ethics Committee (registration number: 5,120,720). Patients who underwent spirometry due to Post-Covid Syndrome were evaluated to analyze the spirometric pattern presented. The following were collected: exam identification data, sex, age, symptom time, the need for mechanical ventilation, and quality of spirometry, in addition to the following exam parameters: FVC, FEV1, FEV1/FVC, FEV 25-75/FVC, and FEV 75, evaluating the Lower Limit of Normality, pre-bronchodilator and post-bronchodilator values. Results: Data from 72 patients were collected. Of these, 55.5% of patients had spirometry results within normal limits. The most frequent respiratory alteration was obstructive respiratory disorder, present in 29.2% of the patients. Conclusions: The presence of dyspnea in patients with normal spirometry may indicate further evaluation of lung function and other etiologies for dyspnea (AU).

Objetivo: Avaliar o padrão de espirometria de pacientes que persistiram com sintomas respiratórios após a infecção pelo SARS-CoV-2. Métodos: Estudo transversal, observacional e retrospectivo realizado em um único centro, aprovado pelo Comitê de Ética local (número do parecer: 5.120.720). Foram avaliados pacientes submetidos a espirometria devido à Síndrome Pós-Covid, a fim de analisar o padrão espirométrico apresentado. Os seguintes dados foram coletados: identificação do exame, sexo, idade, tempo de sintomas, necessidade de ventilação mecânica, qualidade da espirometria, além dos seguintes parâmetros do exame: CVF, VEF1, VEF1/CVF, VEF 25-75/CVF e VEF 75, avaliando o Limite Inferior da Normalidade, valores pré-broncodilatador e pós-broncodilatador. Resultados: Foram coletados dados de 72 pacientes. Destes, 55,5% apresentaram resultados espirométricos dentro dos limites normais. A alteração respiratória mais frequente foi o distúrbio ventilatório obstrutivo, presente em 29,2% dos pa-cientes. Conclusões: A presença de dispneia em pacientes com espirometria dentro da normalidade pode indicar uma avaliação adicional da função pulmonar, assim como outras etiologias para a dispneia (AU).

A consulta de enfermagem no pré-natal por equipes de Saúde da Família em uma cidade mineira / Prenatal nursing consultation by Family Healthcare teams in a city of Minas Gerais / La consulta de enfermería en el prenatal por equipos de Salud Familiar en una ciudad mineira

Objetivou-se investigar o processamento da consulta de enfermagem no pré-natal nas Estratégias Saúde da Família em uma cidade mineira. Trata-se de um estudo descritivo, qualitativo realizado com oito enfermeiros com três a cinco anos de experiência na Atenção Básica. Os dados foram coletados no período de agosto e setembro de 2021, por meio de uma entrevista, analisada mediante Análise Temática. Observou-se que a consulta ocorre subsidiada por linhas guia do Ministério da Saúde e instrumento próprio. O registro é realizado no prontuário, na caderneta das gestantes e em planilhas digitais. Os problemas de enfermagem recorrentes foram baixa adesão ao pré-natal, falta de apoio familiar e nutrição desequilibrada. A sobrecarga de trabalho e a falta de protocolos de enfermagem dificulta o trabalho dos enfermeiros. Conclui-se que a Sistematização da Assistência de Enfermagem é aplicada parcialmente, porém, identificar os problemas de enfermagem durante as consultas é fundamental para a integralidade da assistência

The objective of the study was to investigate nursing consultations processing in prenatal care in Family Health Strategies in a city in Minas Gerais. This is a descriptive, qualitative study carried out with eight nurses with three to five years of experience in Primary Care. Data were collected between August and September 2021, through an interview, analyzed using Thematic Analysis. It was observed that the consultation is subsidized by guidelines from the Ministry of Health and its own instrument. The registration is done on the medical record, in the pregnant women's booklet, and in digital spreadsheets. Recurrent nursing problems were low adherence to prenatal care, lack of family support, and unbalanced nutrition. Work overload and lack of nursing protocols hinder nurses' work. It is concluded that the Systematization of Nursing Care is partially applied; however, identifying nursing problems during consultations is essential for comprehensive care

El objetivo fue investigar la tramitación de las consultas de enfermería en el prenatal en Estrategias de Salud de la Familia en una ciudad de Minas Gerais. Se trata de un estudio descriptivo, cualitativo, realizado con ocho enfermeras con tres a cinco años de experiencia en Atención Primaria. Los datos fueron recolectados entre agosto y septiembre de 2021, mediante entrevista, analizados mediante Análisis Temático. Se observó que la consulta se realiza subsidiada por lineamientos del Ministerio de Salud y instrumento propio. El registro se realiza en la historia clínica, en la libreta de gestantes y en planillas digitales. Los problemas recurrentes de enfermería fueron la baja adherencia a la atención prenatal, la falta de apoyo familiar y la mala nutrición . La sobrecarga de trabajo y la falta de protocolos de enfermería dificultan el trabajo de las enfermeras. Se concluye que la Sistematización de la Atención de Enfermería se aplica parcialmente, sin embargo, identificar los problemas de enfermería durante las consultas es fundamental para la atención integral.

Acute invasive fungal rhinosinusitis in pediatric patients with oncohematological diseases

Abstract Introduction Invasive fungal diseases represent important causes of morbidity and mortality among pediatric oncohematological patients. Acute invasive fungal rhinosinusitis is a rare and aggressive disease that occurs mainly in immunocompromised patients. The mortality rate is high and therefore, accurate and early diagnosis is essential. Objectives The aim of this study was to describe the frequency of acute invasive fungal rhinosinusitis among pediatric oncohematological patients and characterize them with confirmed diagnoses. Methods This was a retrospective study that analyzed the medical records of pediatric patients diagnosed with oncohematological diseases and suspected fungal infections, who were included after obtaining informed consent, from January to December 2017, in the pediatric unit of a tertiary university hospital. Data collected from medical record analysis included the following: underlying diagnosis, absolute neutrophil count, clinical presentation, culture and biopsy results, surgical procedures performed, survival and mortality. Results A total of 27 patients were evaluated, with three suspected cases of acute invasive fungal rhinosinusitis. Histopathological and microbiological analyses confirmed two cases. In both cases, the pathogen isolated in the culture was Fusarium sp. The two confirmed cases were female, aged 12 and 14 years, both with an absolute neutrophil count of 10 cells/μL. The underlying disease of the first patient was acute myeloid leukemia (subtype M5), whereas the second patient presented idiopathic bone marrow aplasia. Conclusion Both confirmed cases of acute invasive fungal rhinosinusitis presented with constitutional symptoms and signs of nasal and sinusital inflammation. This demonstrates the importance of fever as a symptom in immunocompromised patients and it should prompt otorhinolaryngological investigation.

Acute invasive fungal rhinosinusitis in pediatric patients with oncohematological diseases.

INTRODUCTION: Invasive fungal diseases represent important causes of morbidity and mortality among pediatric oncohematological patients. Acute invasive fungal rhinosinusitis is a rare and aggressive disease that occurs mainly in immunocompromised patients. The mortality rate is high and therefore, accurate and early diagnosis is essential. OBJECTIVES: The aim of this study was to describe the frequency of acute invasive fungal rhinosinusitis among pediatric oncohematological patients and characterize them with confirmed diagnoses. METHODS: This was a retrospective study that analyzed the medical records of pediatric patients diagnosed with oncohematological diseases and suspected fungal infections, who were included after obtaining informed consent, from January to December 2017, in the pediatric unit of a tertiary university hospital. Data collected from medical record analysis included the following: underlying diagnosis, absolute neutrophil count, clinical presentation, culture and biopsy results, surgical procedures performed, survival and mortality. RESULTS: A total of 27 patients were evaluated, with three suspected cases of acute invasive fungal rhinosinusitis. Histopathological and microbiological analyses confirmed two cases. In both cases, the pathogen isolated in the culture was Fusarium sp. The two confirmed cases were female, aged 12 and 14 years, both with an absolute neutrophil count of 10cells/µL. The underlying disease of the first patient was acute myeloid leukemia (subtype M5), whereas the second patient presented idiopathic bone marrow aplasia. CONCLUSION: Both confirmed cases of acute invasive fungal rhinosinusitis presented with constitutional symptoms and signs of nasal and sinusital inflammation. This demonstrates the importance of fever as a symptom in immunocompromised patients and it should prompt otorhinolaryngological investigation.

Produtividade e qualidade da framboeseira 'Batum' cultivada sobcobertura plástica e dois espaçamentos em região subtropical / Production and quality of raspberries 'Batum' cultivated under cover plastic and two spacing in subtropical area

Framboesa é uma pequena fruta de grande importância econômica, que contém numerosos compostos fenólicos, com potenciais benéficos à saúde, porém, quando cultivada em regiões subtropicais possui baixa produtividade. Objetivou-se, neste trabalho, avaliar a produtividade de framboeseiras 'Batum', produzidas com ou sem cobertura plástica sobre o dossel das plantas, em duas densidades de plantio, sendo 0,25m e 0,5m entre plantas e 3,0m entre linhas e avaliadas por dois ciclos de produção (2012/13 e 2013/14), em região subtropical. O delineamento experimental adotado foi em blocos ao acaso, em esquema fatorial 2x2x2, com 6 blocos e 10 plantas por parcela. Foram avaliadas as características produtivas como número de frutos por planta, produção por planta e produtividade estimada. Além disso, foram demarcados os índices fenológicos, análises vegetativas e fisiológicas. O menor espaçamento de plantio entre as plantas (0,25m) e o plantio sem cobertura plástica sobre o dossel das plantas resultaram em maior produtividade das framboseiras 'Batum'.

Raspberry is an economically important berry crop, its fruit contains numerous phenolic compounds with potential health benefits, however ver, in subtropical areas has been low production. The objective of this study was to evaluate the productivity of raspberry 'Batum' produced with or without plastic cover over the plant canopy and two planting densities, being 0.25m and 0.5m between plants and 3.0m between rows and cycles (2012/13 and 2013/14), in subtropical area. The experimental design was randomized blocks, factorial 2x2x2 with 6 blocks and 10 plants per plot. It was evaluated the productive plant characteristics such as number of fruits per plant, production per plant and productivity estimated. Moreover,phenological data, vegetative and physiologic analysis. The planting densities at 0.25m between plants and without plastic cover over the plant canopy result in increased productivity of raspberry 'Batum'.

Reliability of the Functional Reach Test and the influence of anthropometric characteristics on test results in subjects with hemiparesis.

First designed as an alternative method of assessing balance and susceptibility to falls among elderly, the Functional Reach Test (FR) has also been used among patients with hemiparesis. Then this study aimed to describe the intra- and inter-rater and the test/re-test reliability of the FR measure in subjects with and without hemiparesis while verifying anthropometric influences on the measurements. The FR was administered to a sample of subjects with hemiparesis and to a control group that was matched by gender and age. A two-way analysis of variance was used to verify the intra-rater reliability. It was calculated using the differences between the averages of the measures obtained during single, double or triple trials. The intra-class correlation coefficient (ICC) was utilized and data plotted using the Bland-Altman method. Associations were analyzed using Pearson's correlation coefficient. In general, the intra-rater analysis did not show significant differences between the measures for the single, double or triple trials. Excellent ICC values were observed, and there were no significant associations with anthropometric parameters for the hemiparesis and control subjects. FR showed good reliability for patients with and without hemiparesis and the test measurements were not significantly associated with the anthropometric characteristics of the subjects.

Comparação entre medidas de descarga, simetria e transferência de peso em indivíduos com e sem hemiparesia / Comparison between bearing, symmetry, and transfer weight measurements in subjects with or without hemiparesis

Avaliação da Simetria e Transferência de Peso (ASTP) foi indicada para se fazer associação entre simetria e atividades funcionais nas hemiparesias, apontando simétricos como mais capacitados. Contudo, tais relações não são claras e divergem com evidências que sugerem assimetrias como estratégias funcionais. Assim, objetivou-se verificar se as medidas subjetivamente determinadas pela ASTP concordam com medidas calculas pela descarga de peso entre os pés. Realizou-se estudo observacional do tipo transversal para amostra de sujeitos com hemiparesia (n=20) pareados por idade e gênero a controles (n=20). Os participantes submeteram-se a procedimentos para obtenção de escore determinado pela ASTP e para cálculo da razão de simetria (RS) na descarga de peso entre os pés obtido por meio de duas balanças digitais. Os resultados obtidos pela ASTP identificaram apenas um sujeito com hemiparesia apresentando simetria, dentre os quatro sujeitos identificados pela RS como simétricos. Ainda, a ASTP não diferenciou assimetrias com sobrecarga para o lado afetado e apresentou correlação significativa somente quando os escores foram analisados com os valores de RS<1(sobrecarga para o lado não afetado). Conclui-se que a ASTP não foi concordante em identificar sujeitos hemiparéticos com descarga de peso compatível com simetria. Ainda, não identificou sobrecargas para o lado afetado que poderia conduzir a análises equivocadas da associação entre simetria e desempenho funcional.

Assessment of symmetry and weight-transfer (ASWT) was indicated to relate symmetry and functional activity in the hemiparesis, pointing as the most qualified symmetrical. However, such relationships are not clear and disagree with evidences suggesting asymmetries as strategies for functional strategies. Then, it was proposed to verify the measurements subjectively determined by ASWT agree with measurements calculated by weight-bearing distribution for each foot. It was applied observational study with transversal design for sample of subjects with hemiparesis (n=20) matched by age and gender with controls (n=20). Participants were included in procedures toobtain scores by ASWT and to calculate symmetry ratio (SR) in the weight-bearing between feet by digital scales. The results obtained by ASWT indicated only one subject with hemiparesis presenting symmetry among four subjects identified as symmetric by SR. Besides, the ASWT did not differ overweight toward the affected side and presented significant correlation only when the scores were analyzed with values of SR<1(overweight toward the non-affected side). It was concluded that the ASWT was not agreementto identify weight-bearing distribution compatible with symmetry. Moreover, it did not identify overweight toward the affected side that could to drive to mistaken analysis of the relationship between symmetries and functional performance.

Is it correct to always consider weight-bearing asymmetrically distributed in individuals with hemiparesis?

Injuries may cause unilateral deterioration of brain areas related to postural control resulting in lateralized motor disability with abnormal asymmetry in weight-bearing distribution. Although overloading toward the nonaffected limb has been described as the preferred posture among individuals with hemiparesis, characterization of the weight-bearing asymmetry is poorly and indirectly described. Therefore, this study aimed to describe weight-bearing distribution during upright stance, establishing criteria to consider asymmetry in hemiparesis when analyzed within the limits defined by controls matched by age and gender. Forty subjects with (n = 20) or without hemiparesis (n = 20) were included in procedures to record weight-bearing values between hemibodies, and these values were used to calculate a symmetry ratio. Control presented 95% confidence interval (CI) of the mean for symmetry ratio ranging from 0.888 to 1.072, defining limits to symmetry. Four subjects with hemiparesis (20%) had symmetry ratios inside limits defined by controls (i.e., weight-bearing symmetrically distributed), and 11 (55%) subjects without hemiparesis showed symmetry ratios outside the limits, suggesting asymmetrical weight-bearing distribution. It was concluded that asymmetry, when present in a control group, was more frequently overloading nonpredominantly used hemibody (nondominant side), differing from a hemiparesis group commonly forced to assume the nonaffected side as the predominantly used hemibody and where the overload was observed.

A Brazilian experience to describe functioning and disability profiles provided by combined use of ICD and ICF in chronic stroke patients at home-care.

PURPOSE: To present experience of combined use of the International Classifications to determine functioning and disability profiles of chronic stroke patients at home-care. METHODS: It was a design observational study with 13 subjects sampled from 39 patients with stroke pre-selected from 115 patients attended by a public home-care service. Their socio-demographic and others independent variables were assessed and frequencies of codified events from International Classification of Diseases (ICD) and International Classification of Functioning, Disability and Health (ICF) were recorded. RESULTS: Endocrine, nutritional and metabolic diseases; diseases of the nervous and circulatory system; diseases of skin and subcutaneous tissue and diseases of the musculoskeletal system and connective tissue were recorded by ICD being complemented by ICF mainly describing impairments in neuromusculoskeletal and movement-related function and structure; limitations in activities and participation for domestic life and barriers for natural environment and human-made changes to environment. Moreover, it was observed functioning profile describing sensory function and structures related to movements preserved; good interpersonal interactions and facilities provided by services and policies. CONCLUSION: Preserved functions and structures related to movement and advantages in interpersonal interactions, public services and healthy policies could be used to guide therapy and to prevent rehospitalisation commonly observed in chronic stroke survivals.