Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add more filters










Language
Publication year range
1.
An Acad Bras Cienc ; 94(2): e20210715, 2022.
Article in English | MEDLINE | ID: mdl-35830084

ABSTRACT

Samanea tubulosa Benth. it has been widely used in traditional medicine to treat inflammatory processes. The present study aimed to investigate the antinociceptive effect and mechanism of action of the fractions obtained from the Samanea tubulosa pods in mice. The antinociceptive activity was evaluated in formalin, capsaicin and glutamate tests and the. The possible mechanisms of action involved in the antinociceptive effect of the hexane and ethyl acetate fraction in the opioid system, also the the K + ATP channels and the L-arigine pathways of nitric oxide were evaluated. The chemical characterization analysis revealed in the hexane fraction the presence of triterpenes such as lupenone and lupeol. In the glutamate test, the hexane and ethyl acetate fractions showed antinociceptive activity at the dose of 12.5 and 25 mg kg-1. The antinociception produced by the hexane and ethyl acetate fractions was significantly reversed by naloxone, indicating that the fractions act through the opioid pathway. Antinociceptive response of the ethyl acetate fraction was blocked by glibenclamide, indicating that this fraction acts via the K + ATP channels activation. It is concluded that the fractions under study exert antinociceptive activity possibly related to the opioid route and through K+ ATP channels activation.


Subject(s)
Acute Pain , Fabaceae , Acute Pain/drug therapy , Adenosine Triphosphate , Analgesics/pharmacology , Analgesics/therapeutic use , Analgesics, Opioid , Animals , Fabaceae/metabolism , Glutamic Acid , Hexanes , Mice
2.
An Acad Bras Cienc ; 90(1): 185-194, 2018.
Article in English | MEDLINE | ID: mdl-29641758

ABSTRACT

The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.) during the observation time of 14 days. The NST (100 and 200 mg/kg, i.p.) inhibited the carrageenan-induced edema from the 1st to the 5th hour (**p<0.01; ***p<0.001). The edematogenic activity induced by dextran, compound 48/80, histamine, serotonin, capsaicin, and prostaglandin E2 was inhibited by NST (100 mg/kg, i.p.) throughout the observation period (**p<0.01; ***p<0.001). The pretreatment with NST (50, 100 or 200 mg/kg, i.p) attenuates the compound 48/80-induced mast cell degranulation (**p<0.01; ***p<0.001). Thus, the inhibition of both mast cell degranulation and release of endogenous mediators are probably involved in the NST-induced antiedematogenic effect.


Subject(s)
Anti-Inflammatory Agents/pharmacology , Edema/drug therapy , Salicylates/pharmacology , Tryptamines/pharmacology , Animals , Anti-Inflammatory Agents/toxicity , Carrageenan , Disease Models, Animal , Edema/chemically induced , Female , Hindlimb , Inflammation Mediators , Male , Mice , Peptides/drug effects , Rats, Wistar , Salicylates/toxicity , Time Factors , Tryptamines/toxicity
3.
An. acad. bras. ciênc ; 90(1): 185-194, Mar. 2018. tab, graf
Article in English | LILACS | ID: biblio-886919

ABSTRACT

ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.) during the observation time of 14 days. The NST (100 and 200 mg/kg, i.p.) inhibited the carrageenan-induced edema from the 1st to the 5th hour (**p<0.01; ***p<0.001). The edematogenic activity induced by dextran, compound 48/80, histamine, serotonin, capsaicin, and prostaglandin E2 was inhibited by NST (100 mg/kg, i.p.) throughout the observation period (**p<0.01; ***p<0.001). The pretreatment with NST (50, 100 or 200 mg/kg, i.p) attenuates the compound 48/80-induced mast cell degranulation (**p<0.01; ***p<0.001). Thus, the inhibition of both mast cell degranulation and release of endogenous mediators are probably involved in the NST-induced antiedematogenic effect.


Subject(s)
Animals , Male , Female , Rats , Tryptamines/pharmacology , Salicylates/pharmacology , Edema/drug therapy , Anti-Inflammatory Agents/pharmacology , Peptides/drug effects , Time Factors , Carrageenan , Tryptamines/toxicity , Salicylates/toxicity , Rats, Wistar , Inflammation Mediators , Disease Models, Animal , Edema/chemically induced , Hindlimb , Anti-Inflammatory Agents/toxicity
4.
J Med Food ; 15(11): 984-91, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22892022

ABSTRACT

This study reports a pharmacological evaluation of anti-inflammatory and anti-ulcer activities of carvacrol, a phenolic monoterpene constituent of essential oils produced by oregano and other several aromatic plants and spices, in experimental models of edema induced by different phlogistic agents and gastric lesions induced by acetic acid. In models of paw edema induced by dextran or histamine, carvacrol was effective at 50 mg/kg (46% and 35%, respectively); in these models, cyproheptadine reduced edema formation (61% and 43%, respectively). In edema induced by substance P, carvacrol (100 mg/kg) and ruthenium red (3 mg/kg) also decreased the edema formation (46% and 40%, respectively). Carvacrol significantly reduced the ear edema induced by 12-O-tetradecanoylphorbol acetate and arachidonic acid at 0.1 mg per ear (43% and 33%, respectively), similar to indomethacin at 0.5 mg per ear or 2.0 mg per ear (55% and 57%, respectively). Carvacrol (at doses of 25, 50, and 100 mg/kg) showed a healing capacity on gastric lesions induced by acid acetic (60%, 91%, and 81%, respectively) after 14 days of treatment. These results suggest that carvacrol acts on different pharmacological targets, probably interfering in release and/or synthesis of inflammatory mediators, such as the prostanoids, and thus favoring the healing process for gastric ulcers.


Subject(s)
Anti-Inflammatory Agents/pharmacology , Anti-Ulcer Agents/pharmacology , Inflammation/drug therapy , Monoterpenes/pharmacology , Oils, Volatile/pharmacology , Origanum/chemistry , Stomach Ulcer/drug therapy , Animals , Arachidonic Acid/adverse effects , Cymenes , Edema/chemically induced , Edema/drug therapy , Female , Indomethacin/adverse effects , Male , Mice , Rats , Rats, Wistar , Ruthenium Red/pharmacology , Stomach Ulcer/chemically induced , Substance P/adverse effects , Tetradecanoylphorbol Acetate/adverse effects , Tetradecanoylphorbol Acetate/analogs & derivatives
SELECTION OF CITATIONS
SEARCH DETAIL
...