ABSTRACT
To test the null hypothesis that limb dominance (laterality) and side of complaint are not associated in a diverse population, nearly 400 patients (40% male, 60% female) of varying age and body size from three South Florida podiatric medical teaching facilities were surveyed in 1995-1996. Radiographs of feet were available for 15% of the patients, and the metatarsus adductus angle was measured on each x-ray. The typical patient was a women (median age, 49 years) of average body weight and average body-mass index. No statistical association was found between laterality and side of complaint in the broader sample, although a significant association did appear in the subsample of patients with bilateral x-rays. The prevalence of metatarsus adductus deformity (metatarsus adductus angle > 15 degrees) among patients with x-rays was 62%. No sex-specific, age-specific, or body size-specific associations were found between handedness and metatarsus adductus deformity.
Subject(s)
Body Mass Index , Foot Deformities/epidemiology , Foot Diseases/etiology , Foot/physiology , Functional Laterality , Podiatry/statistics & numerical data , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Florida/epidemiology , Foot Deformities/physiopathology , Foot Diseases/physiopathology , Humans , Male , Middle Aged , Prevalence , Risk FactorsABSTRACT
Recent studies have suggested the secretion of Atrial Natriuretic Peptide (ANP) is regulated by receptor mediated activation of protein kinase C, which causes the autocrine release of prostaglandins. Prostaglandins stimulate ANP secretion via the adenylate cyclase second messenger system. This report examined the response of right and left atrial ANP secreting cells to the three endothelin isopeptides and to cyclooxygenase inhibition. Our results show that right atrial ANP secretion is stimulated by endothelin 1 and 2 but not 3. In addition, right atrial ANP secretion is reduced by inhibition of cyclooxygenase. In contrast, left atrial ANP secretion is stimulated by endothelin 2 and 3 but not 1. Inhibition of cyclooxygenase did not affect left atrial ANP secretion. These results show the regulation of ANP secretion is different between the two atrial chambers. Right atrial cells appear to contain the prostaglandin-mediated response to protein-kinase C activation, whereas left atrial cells regulate ANP secretion differently.
Subject(s)
Atrial Natriuretic Factor/metabolism , Heart Atria/metabolism , Animals , Aspirin/pharmacology , Atrial Natriuretic Factor/drug effects , Cyclooxygenase Inhibitors/pharmacology , Endothelins/pharmacology , Female , Heart Atria/cytology , Heart Atria/drug effects , Protein Kinase C/drug effects , Protein Kinase C/metabolism , Rats , Rats, Sprague-DawleyABSTRACT
An historical review and case history of amelanotic malignant melanoma presenting as a pedunculated mass on the plantar aspect of the foot is discussed. The patient presented with a rapidly growing, cauliflower-like lesion on the plantar aspect of the left foot. Excisional biopsy revealed amelanotic malignancy. Subsequent surgical intervention was performed to effect a radical excision of local tissues with grafting and inguinal lymphadenectomy.
Subject(s)
Foot Diseases/pathology , Melanoma/pathology , Skin Neoplasms/pathology , Aged , Diagnosis, Differential , Female , Foot Diseases/diagnosis , Foot Diseases/surgery , Humans , Melanoma/diagnosis , Melanoma/surgery , Methods , Skin Neoplasms/diagnosis , Skin Neoplasms/surgeryABSTRACT
Atrial natriuretic peptide (ANP) is released from the atria and acts to regulate blood volume and pressure. The release of ANP appears to be stimulated by atrial distension, initiated by stretch on the cardiocytes. The purpose of the present study was to develop an assay that would allow for the detection of ANP release from single, isolated cells in the absence of distension. Using the reverse hemolytic plaque assay and antibody raised against human-alpha ANP, the release of ANP was detected from trypsin dissociated rat atrial cells. The specificity of the assay was demonstrated by a 67% reduction in ANP plaque forming cells detected following preabsorption of the anti-sera with rat-alpha ANP. The assay also proved efficient in monitoring changes in ANP secreting cell populations, where an acute treatment with dexamethasone resulted in a doubling of the percentage of atrial cardiocytes detected within a 4 hour antibody incubation. Finally, the assay established that about 52% of the dispersed atrial cardiocytes release ANP. The establishment of a plaque assay for ANP release should assist in addressing questions concerning what hormones may regulate ANP secretion directly and also allow for the determination of ANP secreting cell population dynamics.
Subject(s)
Atrial Natriuretic Factor/metabolism , Heart/physiology , Animals , Dexamethasone/pharmacology , Female , Heart Atria/drug effects , Heart Atria/metabolism , Hemolytic Plaque Technique , Immunologic Techniques , Rats , Rats, Inbred StrainsABSTRACT
A discussion is presented about objective correction criteria for hallux abducto valgus surgery. A historical review of commonly used procedures performed for correction at various levels of first ray deformity is related. Based on ideal criteria for base wedge osteotomies, a new template and procedure for base wedge osteotomies derived from computer-augmented graphics is described in detail. This procedure has been referred to as a convergent angled osteotomy (CAO) and effectively reduces the metatarsus primus adductus angle with minimal loss of length, cortex to cortex apposition in closure, relative lengthening with plantarflexion if desired, and a capacity for very stable rigid internal fixation that optimizes recovery from base wedge reduction. Case histories are also presented.
