ABSTRACT
In the paper, methodological requirements are formulated for validation of permissible levels of benz(a)pyrene (B(a)P) in foodstuffs. A list is submitted of allowable levels of this carcinogen in food products for the population of Ukraine, their specific values being dependent on the accepted tolerance daily done intake and on the structure of the standard food ration. Prevention of B(a)P formation and its elimination from the human habitat together with the use of the modern environmentally appropriate technologies designed to prepare food products will form a basis for stabilization of the permissible dose of the carcinogen, finding its way to the human body as a food component through dietary intake.
Subject(s)
Benzo(a)pyrene/standards , Carcinogens/standards , Food Contamination/analysis , Food/standards , Environmental Exposure , Humans , Maximum Allowable Concentration , Nutritional Requirements , Rural Population , Ukraine , Urban PopulationABSTRACT
The paper presents a methodological scheme for regulating the acceptable levels of benz(a)pyrene in the foodstuffs is presented. It also gives a list of the acceptable levels of this carcinogen in the foodstuffs whose specific values depend on its daily dosage and the pattern of a standard diet for the Ukraine's population.
Subject(s)
Benzopyrenes/standards , Carcinogens/standards , Food Analysis/standards , Food Contamination , Humans , Maximum Allowable Concentration , Models, Theoretical , Rural Population , Soil Pollutants , Ukraine , Urban PopulationSubject(s)
Benzo(a)pyrene/toxicity , Carcinogens/toxicity , Dimethylnitrosamine/toxicity , Environmental Pollutants/toxicity , Formaldehyde/toxicity , Neoplasms, Experimental/chemically induced , Administration, Inhalation , Animals , Benzo(a)pyrene/administration & dosage , Carcinogens/administration & dosage , Dimethylnitrosamine/administration & dosage , Environmental Pollutants/administration & dosage , Female , Formaldehyde/administration & dosage , Neoplasm Metastasis , RatsABSTRACT
The paper presents data on the content of nitrosamines (NA), such an nitrosodimethylamine, nitrosodiethylamine, and their precursors (NO2 and amines) in the ambient air of different functional zones of a city. A high correlation between NA and NO2 in the air was established. NO2 was shown to have the leading role as a nitrosating agent in the model system and air during exogenous synthesis. The findings support the possible endogenous production and the role of NO2 in this process.
Subject(s)
Air Pollutants/chemistry , Amines/chemistry , Nitrogen Dioxide/chemistry , Nitrosamines/chemical synthesis , Animals , Carcinogens, Environmental/toxicity , Humans , RatsABSTRACT
The experiment was conducted on white noninbred rats receiving different concentrations of the nitrosamine (NA) precursors NO2 and amidopyrinum. Carcinogenic NAs were determined in the organs of the animals that had inhaled them at concentrations of 0.4, 0.8, and 4.0 mg/m3. There was an increase in tumors in chronic experiments on exposure to NA in the same doses as compared with the controls. It was found that the ambient air NO2 level of 0.4 mg/m3 (MAC 10 mg/m3) should be considered to be hazardous due to the fact that there might be exogenous and endogenous syntheses and that the NA might exert a carcinogenic effect.
