Subject(s)
Glucocorticoids/administration & dosage , Optic Neuropathy, Ischemic/drug therapy , Triamcinolone Acetonide/administration & dosage , Visual Acuity/drug effects , Acute Disease , Glucocorticoids/adverse effects , Humans , Injections/adverse effects , Intraocular Pressure , Ocular Hypertension/etiology , Ocular Hypertension/pathology , Optic Neuropathy, Ischemic/complications , Optic Neuropathy, Ischemic/pathology , Triamcinolone Acetonide/adverse effectsABSTRACT
Luxation of the globe is rare in the general population and may be spontaneous, voluntary, or traumatic. Spontaneous or voluntary globe luxation results from shallow orbit, floppy eyelids, lax orbital ligaments, backward displacement of orbital septum, or proptotic eyes due to orbital tumors or infiltrative processes, as in Grave's ophthalmopathy. The authors report a case with unilateral voluntary globe luxation presented with unilateral progressive visual loss.
Subject(s)
Exophthalmos/complications , Optic Nerve Diseases/drug therapy , Optic Nerve Diseases/etiology , Self-Injurious Behavior/complications , Steroids/therapeutic use , Vision Disorders/drug therapy , Vision Disorders/etiology , Adolescent , Humans , MaleABSTRACT
Non-arteritic anterior ischaemic optic neuropathy is the most common optic neuropathy of the elderly, characterised by unilateral, sudden, painless visual loss. No effective treatment has been proven to reverse or limit the course of this disease. We evaluated the role of intravitreal triamcinolone acetonide injection in eyes with non-arteritic anterior ischaemic optic neuropathy (NAION). Four eyes of four patients with acute NAION received a single intravitreal injection of triamcinolone acetonide (4 mg). The time between visual loss and intravitreal injection varied between four and 10 days. Mean age of patients was 57.25 years (range, 44 to 77 years). All patients experienced some visual gain. No complications related to the injection were observed during the following three months. Intravitreal triamcinolone injection may offer help in limiting the damage in this small group of patients with a relatively short history of visual loss due to NAION.
Subject(s)
Glucocorticoids/therapeutic use , Optic Neuropathy, Ischemic/drug therapy , Triamcinolone Acetonide/therapeutic use , Acute Disease , Adult , Aged , Arteritis/drug therapy , Female , Humans , Injections , Male , Middle Aged , Visual Acuity/drug effects , Visual Fields/drug effects , Vitreous BodySubject(s)
Coloring Agents , Fluorescein Angiography/methods , Indocyanine Green , Ophthalmia, Sympathetic/pathology , Adult , Humans , MaleABSTRACT
We investigated the efficacy of an eutectic mixture of local anesthetics (EMLA) in reducing the pain of a botulinum toxin injection into eyelids. 17 patients with facial dyskinesia (9 blepharospasm and 8 hemifacial spasm) who had been treated regularly with botulinum toxin injections received EMLA cream and placebo. The pain was assessed by the ophthalmologist and the patient. Injection with EMLA cream showed lower pain scores (mean 1.82 +/- 2.13, median 1) than injection with placebo (8.76 +/- 2.17; p = 0.0001). Percutaneous anesthesia induced by EMLA cream is an effective and safe method which improves the comfort in patients who need repeated botulinum toxin injections for their facial dyskinesia.
Subject(s)
Anesthesia, Local , Anesthetics, Combined , Blepharospasm/drug therapy , Botulinum Toxins, Type A/administration & dosage , Eyelids , Hemifacial Spasm/drug therapy , Lidocaine , Prilocaine , Adult , Aged , Aged, 80 and over , Botulinum Toxins, Type A/therapeutic use , Female , Humans , Injections/adverse effects , Lidocaine, Prilocaine Drug Combination , Male , Middle Aged , Ointments , Pain/etiology , Pain/physiopathology , Pain MeasurementABSTRACT
PURPOSE: To correlate the electroretinography (ERG) findings in patients with Duchenne/Becker muscular dystrophy (D/BMD) with the genotype and evaluate the ERG findings in DMD carriers. MATERIALS AND METHODS: Fifteen deletion positive patients with DMD, two deletion positive patients with BMD and six DMD carriers in two families having a positive disease history were evaluated with DNA analysis, ophthalmologic and ERG findings. RESULTS: The mean age of the deletion positive D/BMD patients was 11.1 +/- 3.7 (range: 7-20). No abnormality was detected in the ophthalmic examination of the patients. In three out of 17 patients with D/BMD, ERG was normal whereas in 14 patients electronegative ERG was recorded in scotopic conditions. Mutational alterations observed in these three cases with normal ERG were located exceptionally at 5' hot spot; not like the others within central region. In all DMD carriers ERG findings were recorded as normal. CONCLUSION: ERG findings in D/BMD patients may show some correlations with molecular analysis, whereas it is not useful in DMD carriers.
Subject(s)
Electroretinography , Muscular Dystrophy, Duchenne/genetics , Muscular Dystrophy, Duchenne/physiopathology , Retinal Diseases/genetics , Retinal Diseases/physiopathology , Adolescent , Adult , Case-Control Studies , Child , Chromosome Deletion , DNA/analysis , Female , Genotype , Heterozygote , Humans , Male , Pedigree , Phenotype , Polymorphism, Restriction Fragment LengthABSTRACT
PURPOSE: To report ocular findings in a patient with cutis laxa acquisita. METHODS: Case report RESULTS: A 44-year-old man complained of excessively loose skin for 4 years and had no family history of skin disease. Dermatological examination showed lax and wrinkled skin all over his body. He had bilateral subconjunctival fat prolapse and dermatochalasis. CONCLUSIONS: This case of acquired form of cutis laxa is noteworthy because subconjunctival fat prolapse and dermatochalasis are uncommon at this relatively young age.
