ABSTRACT
Rich clinical material has been gained on carbohydrate and lipid metabolisms, cardiovascular, hepatic, pancreatic, gastric parameters in chronic alcoholics. Functional and morphological changes correlated with duration of chronic alcoholism. No definite relationship existed between the stage of alcoholism and alterations in laboratory and instrumental findings in the course of abstinence syndrome.
Subject(s)
Alcoholism/complications , Viscera/drug effects , Alcoholism/blood , Alcoholism/diagnosis , Alcoholism/physiopathology , Biopsy , Cholangiopancreatography, Endoscopic Retrograde , Chromatography, Thin Layer , Echocardiography , Endoscopy, Digestive System , Exercise Test , Hemodynamics/drug effects , Humans , Radioimmunoassay , Stomach/pathology , Viscera/diagnostic imagingABSTRACT
Basal and maximum gastrin levels were measured in 81 patients with various stages of chronic alcoholism and different periods of alcohol intake, in 23 patients with chronic gastritis of nonalcohol etiology, and in 12 normal subjects. The findings permit a conclusion on the depressive effect of alcohol on the function of gastrin-producing G-cells, this resulting in lowered levels of both basal and maximal gastrin. A direct correlation between the degree of alcohol depression of gastric gastrin production and the length of alcohol consumption was revealed.
Subject(s)
Alcoholism/blood , Gastrins/blood , Adult , Humans , Middle AgedSubject(s)
Alcoholism/metabolism , Gastric Acid/metabolism , Gastric Mucosa/metabolism , Gastritis/metabolism , Pepsin A/metabolism , Adult , Chronic Disease , Humans , Male , Middle AgedABSTRACT
The characteristics of all types of chronic gastritis in patients with chronic alcoholism is given. Alterations of the stomach mucous membrane in alcoholism of different duration are described in detail. The intermediate type filaments in the surface epithelium, cells of glands and macrophages are found which is reported to be a morphological manifestation of alcoholism.
