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Thromb Haemost ; 100(6): 1084-8, 2008 Dec.
Article in English | MEDLINE | ID: mdl-19132234

ABSTRACT

Transcatheter local thrombolytic therapy in patients with acute, extended splanchnic venous thrombosis is controversial. Here we present our single-center experience with transcatheter thrombolytic therapy in these patients. All consecutive patients (n = 12) with acute, extended splanchnic venous thrombosis who underwent transcatheter thrombolytic therapy in our hospital, were included in this study. Thrombolytic therapy was successful for three thrombotic events and partially successful for four thrombotic events. Two patients developed minor procedure-related bleeding (17%). Six patients (50%) developed major procedure-related bleeding, with a fatal outcome in two. Transcatheter thrombolytic therapy in patients with acute, extended splanchnic vein thrombosis is found to be associated with a high rate of procedure-related bleeding. Therefore, thrombolysis should be reserved for patients in whom the venous flow cannot be restored by using conventional anticoagulant therapy or stent placement across the thrombosed vessel segment.


Subject(s)
Budd-Chiari Syndrome/drug therapy , Fibrinolytic Agents/administration & dosage , Portal Vein , Splanchnic Circulation , Thrombolytic Therapy , Venous Thrombosis/drug therapy , Adult , Budd-Chiari Syndrome/etiology , Budd-Chiari Syndrome/physiopathology , Female , Fibrinogen/analysis , Fibrinolytic Agents/adverse effects , Hemorrhage/chemically induced , Hemorrhage/mortality , Humans , Liver Cirrhosis/complications , Liver Cirrhosis/drug therapy , Liver Cirrhosis/physiopathology , Liver Function Tests , Male , Middle Aged , Patient Selection , Portal Vein/physiopathology , Portasystemic Shunt, Transjugular Intrahepatic , Retrospective Studies , Risk Assessment , Thrombolytic Therapy/adverse effects , Thrombolytic Therapy/mortality , Treatment Outcome , Vascular Patency , Venous Thrombosis/etiology , Venous Thrombosis/physiopathology
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