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Eur Ann Allergy Clin Immunol ; 43(2): 58-60, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21608374

ABSTRACT

A 3-year prospective post marketing survey on the safety of the recently developed ultrashort pre-seasonal subcutaneous immunotherapy (uSCIT-MPL4) with pollen allergoids adjuvanted with monophosphoryl lipid A was performed. A total of 510 patients received uSCIT-MPL4, 61% for grass, 35.7% for birch, 13.2% for parietaria and 3% for other pollens (ragweed, mugwort, and olive). A total of 3308 injections were given and the mean duration of uSCIT-MPL-4 was 2.3 years. Overall, only 7 slight systemic reactions (SR) were observed in 510 patients (1.37%) and 2.11/1000 injections suggesting that this treatment is even safer than traditional depot injection SIT.


Subject(s)
Adjuvants, Immunologic/administration & dosage , Desensitization, Immunologic/adverse effects , Lipid A/analogs & derivatives , Plant Extracts/adverse effects , Adult , Allergoids , Female , Humans , Italy , Lipid A/administration & dosage , Male , Middle Aged , Prospective Studies
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