ABSTRACT
Non-obstetrical fetal head injury is an unusual clinical event. While multiple case reports describe motor vehicle collisions resulting in intrauterine fetal skull fractures, management of these injuries has not been emphasized. We report a case of a depressed fetal skull fracture with massive subgaleal and subperiosteal hemorrhage requiring neurosurgical intervention with good clinical outcomes for both mother and infant dyad.
Subject(s)
Craniotomy/methods , Decompression, Surgical/methods , Fetal Distress/surgery , Plastic Surgery Procedures/methods , Prenatal Injuries/surgery , Skull Fractures/embryology , Accidents, Traffic , Adult , Cesarean Section , Dura Mater/surgery , Female , Fetal Distress/diagnostic imaging , Fetal Distress/physiopathology , Gestational Age , Humans , Infant, Newborn , Intensive Care, Neonatal , Pregnancy , Pregnant Women , Prenatal Injuries/diagnostic imaging , Prenatal Injuries/physiopathology , Skull Fractures/diagnostic imaging , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
This study examined the question of whether previous exposure to cytostatic drugs by oncology nurses was sufficient to lead to haematological phenotypical subclinical abnormalities which had previously been identified in a population of patients who had received chemotherapy as an adjuvant to breast surgery. A comparison of baseline haematological parameters, and the results of a prednisolone stimulation test, was made between nurses regularly coming into contact with such agents and age-adjusted group of nurses who had not been exposed. Although there is a persistent trend toward lower neutrophils, platelets, monocytes and neutrophil reserves in the nurses who handled antineoplastic agents, a statistically significant decrement in these parameters was not identified. Such a finding should help to reassure individuals who have had similar exposure, but does not negate the importance of following published recommended guidelines for the handling and dispensing of antineoplastic agents.
Subject(s)
Antineoplastic Agents/adverse effects , Nurses , Occupational Diseases/chemically induced , Adult , Drug Compounding , Hemoglobins/analysis , Humans , Leukocyte Count , Middle Aged , Occupational Diseases/blood , Prednisolone/pharmacologyABSTRACT
Two patients became pregnant while receiving adjuvant chemotherapy for breast cancer following mastectomy. These cases suggest that the significant prolongation of disease-free survival seen in young premenopausal patients may not be ascribable to ovarian failure alone. While the degree to which these patients will benefit from adjuvant therapy is unknown, it is clear that the agents used did not affect fertility. The need to instruct such patients in the necessity for using nonoral contraceptive techniques is stressed.
