ABSTRACT
Acute disseminated staphylococcal disease (ADSD) constitutes a potentially fatal and alarmingly increasing disorder. We describe an unusual case of a two-and-a-half-year-old female with community-acquired methicillin-resistant Staphylococcus aureus induced septic shock complicated by osteomyelitis and deep vein thrombosis. Aggressive management with long-term antistaphylococcal therapy, anticoagulation and intensive care support was implemented with complete resolution of disseminated inflammation.
Subject(s)
Staphylococcal Infections , Female , Humans , Infant, Newborn , Severity of Illness Index , Staphylococcal Infections/diagnosis , Staphylococcal Infections/therapyABSTRACT
We present a unique case of life-threatening pneumococcal meningitis complicated by vasculitis in a fully vaccinated 4-year-old female with the heptavalent conjugate vaccine for Streptococcus pneumoniae (PCV7). Serotype 23F was isolated in both blood and cerebral spinal fluid (CSF) samples. Pulses of methylprednisolone were promptly initiated in addition to antibiotics leading to a good recovery. CSF studies and magnetic resonance imaging (MRI) of the brain were used for diagnosis and monitoring the response to corticoid therapy. We report the investigations of a child with failure of PCV7 vaccine to protect against vaccine-serotype invasive disease. Use of corticosteroids and temporal association with changes in brain imaging are described for the first time in literature.
Subject(s)
Diffusion Magnetic Resonance Imaging/methods , Magnetic Resonance Imaging/methods , Meningitis, Pneumococcal/diagnosis , Pneumococcal Vaccines/administration & dosage , Child, Preschool , Female , Heptavalent Pneumococcal Conjugate Vaccine , Humans , Meningitis, Pneumococcal/complications , Neuroimaging/methods , Vasculitis, Central Nervous System/complicationsABSTRACT
We evaluated the effect of three carbapenems on gut colonization of mice by Candida albicans. A total of 150 Crl:CD1 (ICR) BR mice were fed chow containing C. albicans or regular chow. Both groups were subsequently treated either with one carbapenem or with normal saline for 10 days. Stool cultures to determine colonization by C. albicans were performed immediately before, at the end, and one week after the end of treatment. Candida-colonized mice that received carbapenems had substantially higher C. albicans concentrations than control animals fed C. albicans, especially if they received ertapenem. Mice fed regular chow and treated with the study antibiotics or saline did not have Candida in their stools. Candida was not detected in the internal organs of any group of mice.
