ABSTRACT
This postmenopausal patient developed hirsutism following a surgical procedure. Thorough lab work directed us to the unusual cause.
Subject(s)
Hirsutism/etiology , Leydig Cell Tumor/diagnosis , Ovarian Neoplasms/diagnosis , Postmenopause , Testosterone/blood , Aged , Female , Hirsutism/blood , Humans , Leydig Cell Tumor/metabolism , Leydig Cell Tumor/pathology , Ovarian Neoplasms/metabolism , Ovarian Neoplasms/pathologyABSTRACT
We had our suspicions as to the diagnosis, but a particular sign was missing. The biopsy settled things.
Subject(s)
Skin/pathology , Urticaria Pigmentosa/diagnosis , Biopsy , Child, Preschool , Female , Humans , Urticaria Pigmentosa/etiology , Urticaria Pigmentosa/pathology , Urticaria Pigmentosa/therapyABSTRACT
Imiquimod is used topically in the treatment of numerous dermatologic conditions. Imiquimod modifies the immune response through cytokine induction of the T-cell helper subset, correlating with the expression of interferon alpha, tumor necrosis factor alpha, interferon gamma, and interleukins (ILs) 1 and 12. Reciprocal inhibition of TH2 immune response occurs via up-regulation of interferon gamma and down-regulation of TH2-associated cytokines, including IL-4, IL-5, IL-6, IL-10, and IL-13. Alopecia universalis is a severe form of alopecia thought to arise from T-cell mediated autoimmune disease of the hair follicle. There have been no case reports noting a beneficial effect of topical imiquimod in the treatment of alopecia universalis. We present a case of a 15-year-old adolescent girl with alopecia universalis since age 8 who experienced transient hair growth after topical application of imiquimod.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Alopecia/drug therapy , Aminoquinolines/therapeutic use , Adolescent , Female , Humans , ImiquimodABSTRACT
BACKGROUND: Gingival fibromas and dental pitting are among the diagnostic criteria for tuberous sclerosis complex (TSC). OBJECTIVE: Our goal was to document the oral findings in 58 adult patients with TSC. RESULTS: Forty patients (69%) had oral fibromas, appearing mostly on the attached or interdental gingiva. Other oral mucosal sites with fibromas included buccal and labial mucosa, the superior labial frenulum, palate, and tongue. In all, 56 patients (97%) had multiple dental enamel pits. LIMITATIONS: This case series comprised predominantly adult women with TSC and lymphangioleiomyomatosis. CONCLUSIONS: Oral fibromas in TSC are mostly, but not exclusively, gingival. Dental pits are present in nearly all patients. The multiple oral papules in TSC may appear similar to those observed in Cowden syndrome, Birt-Hogg-Dubé syndrome, and rarely in multiple endocrine neoplasia type 1.
Subject(s)
Mouth Diseases/etiology , Tooth Diseases/etiology , Tuberous Sclerosis/complications , Adult , Aged , Female , Fibromatosis, Gingival/etiology , Humans , Lung Neoplasms/etiology , Lymphangioleiomyomatosis/etiology , Male , Middle AgedABSTRACT
A causal relationship is thought to exist between several medications and the development of bullous pemphigoid. Commonly implicated medications include furosemide, penicillins, and ibuprofen. The following is a case report of an elderly man who developed generalized bullous pemphigoid for the first time after beginning therapy with an oral beta-blocker. A literature search revealed only 2 other reports of beta-blocker associated bullous pemphigoid. As both bullous pemphigoid and beta-blockers are common in elderly patients, dermatologists may want to consider beta-blockers as potential etiological agents in the development of bullous pemphigoid.
