[Characteristics of cellular immunosuppression models of allotransplantation reactions]. / Kharakteristika modelei kletochnoi immunosupresii allotransplantatsionnykh reaktsii.

Two developed experimental models based on induction of suppression by alloantigens in mice and on testing of its effect on the level of proliferative immune reaction during systemic or local adoptive transfer of spleen suppressor cells to syngeneic mice were used. Formation of immunosuppressive mechanisms has been shown to depend on alloantigen (H-2, Mls) properties. Dynamics of suppression development, a degree of its specificity, role of T cells and macrophages in suppression and sensitivity to cyclophosphamide were studied. The possibility to employ the proposed models in the studies of immunosuppression peculiarities during tumour development is considered.

[Effect of the splenic cells of tumor-bearing mice on the allograft immune response]. / Vliianie kletok selezenki myshei s opukhol'iu na allotransplantatsionnyi immunnyi otvet.

An earlier experimental model employing quantitative analysis of allotransplantation immune response in vivo and registration of the functional activity of immunoregulatory cells was used. It was established that syngeneic transfer of spleen cells from mice bearing 20-methylcholanthrene-induced tumors to normal intact mice modifies immune response to allogeneic cells. The effect of splenocytes was found to depend on the rate of tumor growth. Moreover, the method of syngeneic transfer (systemic application or local injection) of immunoregulatory cells appeared to be of great importance for the realization of suppressive or stimulative effect of splenocytes. Possible causes of changes in the extent and nature of the effect of lymphocytes from tumor-bearing mice on allotransplantation immune response in vivo are discussed.