ABSTRACT
A correlative bright-field and hyperspectral analysis of full-thickness, cutaneous wounds in a porcine model was undertaken to investigate the efficacy of hyperspectral imaging as an alternate method for wound identification. Analysis of a randomly selected specimen yielded distinct spectral signatures for cutaneous regions of interest including the epidermis, injured dermis, and normal dermis. The scanning of the entire specimen group using these hyperspectral signatures revealed an exclusionary, pseudo-color pattern whereby a central wound region was consistently defined by a unique spectral signature. An algorithm was derived as an objective tool for the comparison of the wound regions defined by the hyperspectral classification versus the pathologists' manual tracings. The dimensions of the wound identified in the hyperspectral assay did not differ significantly from the wound region identified by the pathologists using standard bright-field microscopy. These data indicate that hyperspectral analysis may provide a high-throughput alternative for wound estimation that approximates standard bright-field imaging and pathologist evaluation.
Subject(s)
Image Interpretation, Computer-Assisted/methods , Microscopy/methods , Skin/injuries , Skin/pathology , Spectrum Analysis/methods , Algorithms , Animals , Biopsy/instrumentation , Biopsy/methods , Burns/pathology , Microscopy/instrumentation , Microscopy, Fluorescence/methods , Observer Variation , Pattern Recognition, Automated , Reproducibility of Results , Sensitivity and Specificity , Single-Blind Method , Spectrum Analysis/instrumentation , SwineABSTRACT
A retrospective study was conducted on female patients who were screened for Chlamydia trachomatis and Neisseria gonorrhea. The purpose of the study was to determine if any factors predict empiric therapy at the index visit. Of 911 patients enrolled in the study, 100 were found to have positive DNA screens and 54 were given empiric therapy. A logistic regression was used to test the ability of age, ethnicity, DNA probe result and provider type (physician or midlevel provider), to predict empiric treatment. DNA probe result and provider type were the only 2 factors that were found to predict empiric therapy. A subsequent analysis using a Cochran-Mantel-Hanszel test to control for DNA probe result revealed that the provider type remained the only variable that predicted empiric treatment.
Subject(s)
Chlamydia Infections/drug therapy , Emergency Service, Hospital , Gonorrhea/drug therapy , Mass Screening , Adolescent , Adult , Child , Chlamydia Infections/prevention & control , DNA Probes , Female , Gonorrhea/prevention & control , Humans , New York , Retrospective Studies , RiskABSTRACT
PIP: In Drs. Sprang and Neerhof's article regarding the partial-birth abortion law, it is noted that proposed federal legislation would ban only the intact dilatation and extraction (D&X) procedure. Such an argument is fallacious, since the wording of the proposed federal legislation about D&X is vague when compared with the ACOG definition of intact D&X. This may be because intact D&X, described for the public in a graphic and disturbing text, is being used by the anti-choice movement to achieve its desired outcome of criminalization of all abortion procedures. In these terms, the question as to why the precise ACOG definition of intact D&X is not used in the language of the legislation is asked. Moreover, it is believed that the authors of the article have disregarded the woman's health and well-being because of their obsession with the fetus's rights. Overall, it is suggested that real efforts must be made to care for women whether that entails helping them find ways out of abusive relationships, assisting them in nurturing children, or providing them with effective birth control, including abortion.^ieng
