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1.
Phys Ther ; 100(10): 1793-1804, 2020 09 28.
Article in English | MEDLINE | ID: mdl-32556249

ABSTRACT

OBJECTIVE: Changing Behavior through Physical Therapy (CBPT), a cognitive-behavioral-based program, has been shown to improve outcomes after lumbar spine surgery in patients with a high psychosocial risk profile; however, little is known about potential mechanisms associated with CBPT treatment effects. The purpose of this study was to explore potential mediators underlying CBPT efficacy after spine surgery. METHODS: In this secondary analysis, 86 participants were enrolled in a randomized trial comparing a postoperative CBPT (n = 43) and education program (n = 43). Participants completed validated questionnaires at 6 weeks (baseline) and 3 and 6 months following surgery for back pain (Brief Pain Inventory), disability (Oswestry Disability Index), physical health (12-Item Short-Form Health Survey), fear of movement (Tampa Scale for Kinesiophobia), pain catastrophizing (Pain Catastrophizing Scale), and pain self-efficacy (Pain Self-Efficacy Questionnaire). Parallel multiple mediation analyses using Statistical Package for the Social Sciences (SPSS) were conducted to examine whether 3- and 6-month changes in fear of movement, pain catastrophizing, and pain self-efficacy mediate treatment outcome effects at 6 months. RESULTS: Six-month changes, but not 3-month changes, in fear of movement and pain self-efficacy mediated postoperative outcomes at 6 months. Specifically, changes in fear of movement mediated the effects of CBPT treatment on disability (indirect effect = -2.0 [95% CI = -4.3 to 0.3]), whereas changes in pain self-efficacy mediated the effects of CBPT treatment on physical health (indirect effect = 3.5 [95% CI = 1.2 to 6.1]). CONCLUSIONS: This study advances evidence on potential mechanisms underlying cognitive-behavioral strategies. Future work with larger samples is needed to establish whether these factors are a definitive causal mechanism. IMPACT: Fear of movement and pain self-efficacy may be important mechanisms to consider when developing and testing psychologically informed physical therapy programs.


Subject(s)
Cognitive Behavioral Therapy/methods , Disabled Persons/psychology , Physical Therapy Modalities/statistics & numerical data , Spinal Diseases/therapy , Adult , Disability Evaluation , Female , Humans , Male , Middle Aged , Pain, Postoperative/prevention & control , Spinal Diseases/psychology , Surveys and Questionnaires
2.
Spine J ; 19(12): 1969-1976, 2019 12.
Article in English | MEDLINE | ID: mdl-31442617

ABSTRACT

BACKGROUND CONTEXT: Low back pain has an immense impact on the US economy. A significant number of patients undergo surgical management in order to regain meaningful functionality in daily life and in the workplace. Return to work (RTW) is a key metric in surgical outcomes, as it has profound implications for both individual patients and the economy at large. PURPOSE: In this study, we investigated the factors associated with RTW in patients who achieved otherwise favorable outcomes after lumbar spine surgery. STUDY DESIGN/SETTING: This study retrospectively analyzes prospectively collected data from the lumbar module of national spine registry, the Quality Outcomes Database (QOD). PATIENT SAMPLE: The lumbar module of QOD includes patients undergoing lumbar surgery for primary stenosis, disc herniation, spondylolisthesis (Grade I) and symptomatic mechanical disc collapse or revision surgery for recurrent same-level disc herniation, pseudarthrosis, and adjacent segment disease. Exclusion criteria included age under 18 years and diagnoses of infection, tumor, or trauma as the cause of lumbar-related pain. OUTCOME MEASURES: The outcome of interest for this study was the return to work 12-month after surgery. METHODS: The lumbar module of QOD was queried for patients who were employed at the time of surgery. Good outcomes were defined as patients who had no adverse events (readmissions/complications), had achieved 30% improvement in Oswestry disability index (ODI) and were satisfied (NASS satisfaction) at 3-month post-surgery. Distinct multivariable logistic regression models were fitted with 12-month RTW as outcome for a. overall population and b. the patients with good outcomes. The variables included in the models were age, gender, race, insurance type, education level, occupation type, currently working/on-leave status, workers' compensation, ambulatory status, smoking status, anxiety, depression, symptom duration, number of spinal levels, diabetes, motor deficit, and preoperative back-pain, leg-pain and ODI score. RESULTS: Of the total 12,435 patients, 10,604 (85.3%) had successful RTW at 1-year postsurgery. Among patients who achieved good surgical outcomes, 605 (7%) failed to RTW. For both the overall and subgroup analysis, older patients had lower odds of RTW. Females had lower odds of RTW compared with males and patients with higher back pain and baseline ODI had lower odds of RTW. Patients with longer duration of symptoms, more physically demanding occupations, worker's compensation claim and those who had short-term disability leave at the time of surgery had lower odds of RTW independent of their good surgical outcomes. CONCLUSIONS: This study identifies certain risk factors for failure to RTW independent of surgical outcomes. Most of these risk factors are occupational; hence, involving the patient's employer in treatment process and setting realistic expectations may help improve the patients' work-related functionality.


Subject(s)
Elective Surgical Procedures/statistics & numerical data , Intervertebral Disc Degeneration/surgery , Intervertebral Disc Displacement/surgery , Neurosurgical Procedures/statistics & numerical data , Postoperative Complications/epidemiology , Return to Work/statistics & numerical data , Adult , Aged , Elective Surgical Procedures/adverse effects , Female , Humans , Intervertebral Disc Degeneration/epidemiology , Intervertebral Disc Displacement/epidemiology , Lumbar Vertebrae/surgery , Male , Middle Aged , Neurosurgical Procedures/adverse effects , Unemployment/statistics & numerical data
3.
J Bone Joint Surg Am ; 100(19): 1713-1714, 2018 Oct 03.
Article in English | MEDLINE | ID: mdl-30278002
4.
J Pain ; 17(1): 76-89, 2016 01.
Article in English | MEDLINE | ID: mdl-26476267

ABSTRACT

UNLABELLED: The purpose of this study was to determine the efficacy of a cognitive-behavioral-based physical therapy (CBPT) program for improving outcomes in patients after lumbar spine surgery. A randomized controlled trial was conducted on 86 adults undergoing a laminectomy with or without arthrodesis for a lumbar degenerative condition. Patients were screened preoperatively for high fear of movement using the Tampa Scale for Kinesiophobia. Randomization to either CBPT or an education program occurred at 6 weeks after surgery. Assessments were completed pretreatment, posttreatment and at 3-month follow-up. The primary outcomes were pain and disability measured by the Brief Pain Inventory and Oswestry Disability Index. Secondary outcomes included general health (SF-12) and performance-based tests (5-Chair Stand, Timed Up and Go, 10-Meter Walk). Multivariable linear regression analyses found that CBPT participants had significantly greater decreases in pain and disability and increases in general health and physical performance compared with the education group at the 3-month follow-up. Results suggest a targeted CBPT program may result in significant and clinically meaningful improvement in postoperative outcomes. CBPT has the potential to be an evidence-based program that clinicians can recommend for patients at risk for poor recovery after spine surgery. PERSPECTIVE: This study investigated a targeted cognitive-behavioral-based physical therapy program for patients after lumbar spine surgery. Findings lend support to the hypothesis that incorporating cognitive-behavioral strategies into postoperative physical therapy may address psychosocial risk factors and improve pain, disability, general health, and physical performance outcomes.


Subject(s)
Chronic Pain/therapy , Cognitive Behavioral Therapy/methods , Lumbar Vertebrae/surgery , Pain, Postoperative/therapy , Physical Therapy Modalities , Spinal Diseases/surgery , Activities of Daily Living/psychology , Adult , Aged , Chronic Pain/etiology , Chronic Pain/psychology , Female , Health Education , Humans , Male , Middle Aged , Pain, Postoperative/etiology , Pain, Postoperative/psychology
5.
Spine J ; 14(7): 1325-31, 2014 Jul 01.
Article in English | MEDLINE | ID: mdl-24462532

ABSTRACT

BACKGROUND CONTEXT: A physician's role within a workers' compensation injury extends far beyond just evaluation and treatment with several socioeconomic and psychological factors at play compared with similar injuries occurring outside of the workplace. Although workers' compensation statutes vary among states, all have several basic features with the overall goal of returning the injured worker to maximal function in the shortest time period, with the least residual disability and shortest time away from work. PURPOSE: To help physicians unfamiliar with the workers' compensation process accomplish these goals. STUDY DESIGN: Review. METHODS: Educational review. RESULTS: The streamlined review addresses the topics of why is workers' compensation necessary; what does workers' compensation cover; progression after work injury; impairment and maximum medical improvement, including how to use the sixth edition of American Medical Association's (AMA) Guides to the evaluation of permanent impairment (Guides); completion of work injury claim after impairment rating; independent medical evaluation; and causation. CONCLUSIONS: In the "no-fault" workers' compensation system, physicians play a key role in progressing the claim along and, more importantly, getting the injured worker back to work as soon as safely possible. Physicians should remain familiar with the workers' compensation process, along with how to properly use the AMA Guides.


Subject(s)
Physician's Role , Workers' Compensation , American Medical Association , Disability Evaluation , Guidelines as Topic , Humans , Insurance Claim Review , Return to Work , United States , Workers' Compensation/economics
6.
Phys Ther ; 93(8): 1130-9, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23599351

ABSTRACT

BACKGROUND AND PURPOSE: Fear of movement is a risk factor for poor postoperative outcomes in patients following spine surgery. The purposes of this case series were: (1) to describe the effects of a cognitive-behavioral-based physical therapy (CBPT) intervention in patients with high fear of movement following lumbar spine surgery and (2) to assess the feasibility of physical therapists delivering cognitive-behavioral techniques over the telephone. CASE DESCRIPTION: Eight patients who underwent surgery for a lumbar degenerative condition completed the 6-session CBPT intervention. The intervention included empirically supported behavioral self-management, problem solving, and cognitive restructuring and relaxation strategies and was conducted in person and then weekly over the phone. Patient-reported outcomes of pain and disability were assessed at baseline (6 weeks after surgery), postintervention (3 months after surgery), and at follow-up (6 months after surgery). Performance-based outcomes were tested at baseline and postintervention. The outcome measures were the Brief Pain Inventory, Oswestry Disability Index, 5-Chair Stand Test, and 10-Meter Walk Test. OUTCOMES: Seven of the patients demonstrated a clinically significant reduction in pain, and all 8 of the patients had a clinically significant reduction in disability at 6-month follow-up. Improvement on the performance-based tests also was noted postintervention, with 5 patients demonstrating clinically meaningful change on the 10-Meter Walk Test. DISCUSSION: The findings suggest that physical therapists can feasibly implement cognitive-behavioral skills over the telephone and may positively affect outcomes after spine surgery. However, a randomized clinical trial is needed to confirm the results of this case series and the efficacy of the CBPT intervention. Clinical implications include broadening the availability of well-accepted cognitive-behavioral strategies by expanding implementation to physical therapists and through a telephone delivery model.


Subject(s)
Cognitive Behavioral Therapy , Fear , Lumbar Vertebrae/surgery , Physical Therapy Modalities , Spinal Diseases/psychology , Spinal Diseases/rehabilitation , Spinal Diseases/surgery , Adult , Aged , Disability Evaluation , Female , Humans , Male , Middle Aged , Pain Measurement , Quality of Life , Reproducibility of Results , Risk Factors , Surveys and Questionnaires , Treatment Outcome
8.
Spine (Phila Pa 1976) ; 37(21): E1348-55, 2012 Oct 01.
Article in English | MEDLINE | ID: mdl-22828710

ABSTRACT

STUDY DESIGN: Systematic review. OBJECTIVE: To perform a systematic review of the available literature for those studies that evaluated the role of whole-body vibration (WBV) on the spine, using imaging modalities as well as an estimation of WBV exposure. SUMMARY OF BACKGROUND DATA: Numerous comparative studies have reported a possible association between the occurrence of spinal symptoms and exposure to WBV. These exposures have commonly been examined in the work environment largely through self-reported questionnaires only. From a scientific perspective, the majority of studies emphasize symptoms and lack objective medical evidence, such as spinal imaging, to help establish a specific spinal disorder. Because both neck and low back pain comprise symptoms that can arise from a host of factors including age, a casual link between spinal disorders and WBV cannot be affirmed. METHODS: MEDLINE and EMBASE were searched for studies related to WBV and spinal symptoms, diagnosis, and/or disorders. Our searches were limited to studies published prior to August 2011. The resulting 700 citations (after excluding 354 duplicates) were then screened by 3 independent reviewers on the basis of the following predetermined inclusion and exclusion criteria: inclusion-clinical studies with imaging evaluation (radiographs, computed tomographic scans, and/or magnetic resonance images) and documented WBV exposure (occupation, amount of WBV, and/or duration); exclusion-reliance solely on self-reporting of symptoms (neck pain, low back pain, and/or sciatica), those articles based on a clinical diagnosis without use of imaging, and in vitro/animal/biomechanical studies. RESULTS: Only 7 studies met the inclusion criteria for this systematic review. Included were 5 retrospective cohort and 2 cross-sectional studies. Although mixed results and conclusions were found, the majority of studies did not identify an association between WBV exposure and an abnormal spinal imaging finding indicating damage of the spine. We should also stress that each included study has limitations secondary to quantifying WBV exposure accurately, both as a single encounter and as a total exposure over years. CONCLUSION: Based on our results from this systematic review, no causality can be shown between WBV and abnormal spinal imaging findings. With the conflicting data available in the literature, WBV has not been established as a cause for objective spinal pathological changes on a scientific basis.


Subject(s)
Spinal Diseases/diagnostic imaging , Spinal Diseases/etiology , Vibration/adverse effects , Humans , Low Back Pain/etiology , Magnetic Resonance Imaging , Neck Pain/etiology , Risk Assessment , Risk Factors , Tomography, X-Ray Computed
9.
J Biomed Mater Res B Appl Biomater ; 100(1): 32-40, 2012 Jan.
Article in English | MEDLINE | ID: mdl-21953899

ABSTRACT

Calcium phosphate (CaP)/polymer composites have been studied as an alternative graft material for the treatment of bone defects. In this study, lysine-triisocyanate-based polyurethane (PUR) composites were synthesized from both hydroxyapatite (HA) and ß-tricalcium phosphate (TCP) to reduce the brittleness of CaP and increase the bioactivity of the polymer. The mechanical properties and in vitro cellular response were investigated for both HA/PUR and TCP/PUR composites. The composites were implanted in femoral defects in rats, and in vivo bioactivity was evaluated by X-rays, micro-computed tomography (µCT), and histological sections. In biomechanical testing, PUR improved the mechanical properties of the CaP, thus rendering it potentially suitable for weight-bearing applications. In vitro cell culture studies showed that CaP/PUR composites are biocompatible, with ß-TCP enhancing the cell viability and proliferation relative to HA. CaP/PUR composites also supported the differentiation of osteoblastic cells on the materials. When implanted in rat femoral defects, the CaP/PUR composites were biocompatible and osteoconductive with no adverse inflammatory response, as evidenced by X-rays, µCT images, and histological sections. Additionally, a histological examination showed evidence of cellular infiltration and appositional remodeling. These results suggest that CaP/PUR composites could be potentially useful biomaterials for weight-bearing orthopaedic implants.


Subject(s)
Bone Substitutes/pharmacology , Calcium Phosphates/pharmacology , Durapatite/pharmacology , Femur/injuries , Materials Testing , Polyurethanes/pharmacology , Animals , Bone Substitutes/chemistry , Calcium Phosphates/chemistry , Cell Line , Durapatite/chemistry , Femur/diagnostic imaging , Male , Mice , Polyurethanes/chemistry , Rats , Rats, Sprague-Dawley , X-Ray Microtomography
11.
Spine J ; 11(7): 641-6, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21600853

ABSTRACT

BACKGROUND CONTEXT: Despite improvements through the use of prophylactic systemic antibiotics, surgical site infections remain a significant problem in the treatment of traumatic spine injuries. Infection rates as high as 10% have been reported in this population. The impact on patients and cost of treating such infections is profound. Local delivery of antibiotics has been found to be efficacious in animal and human studies as an adjunct to systemic antibiotics in surgical site infection prophylaxis. PURPOSE: To evaluate the efficacy of using vancomycin powder in surgical sites to prevent infections. STUDY DESIGN: Retrospective case review. PATIENT SAMPLE: Patients who underwent posterior spine fusions for traumatic injuries over a 2-year period at a single academic center. OUTCOME MEASURES: Clinical outcome determined was the incidence of either superficial or deep postoperative wound infections. METHODS: A retrospective review of 110 patients with traumatic spine injuries treated with instrumented posterior spine fusions over a 2-year period at a single academic center was performed. One group (control group) received standard systemic prophylaxis only, whereas another (treatment group) received vancomycin powder in the surgical wound in addition to systemic prophylaxis. Patient demographics and perioperative information obtained included history of previous spine surgeries, substance use, diabetes, body mass index, level of injury, presence of neurologic deficit, operative time, and estimated blood loss. Incidence of infection was the primary outcome evaluated. RESULTS: The control (N=54) and treatment groups (N=56) were statistically similar. A statistically significant difference in infection rate was found between the treatment group (0%) and control group (13%, p=.02) without any adverse events. No adverse effects were noted from use of the vancomycin powder. CONCLUSIONS: The use of vancomycin powder in surgical wounds may significantly reduce the incidence of infection in patients with traumatic spine injuries treated with instrumented posterior spine fusion. Applying vancomycin powder to surgical wounds is a promising means of preventing costly and harmful postoperative wound infections in high-risk populations.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Antibiotic Prophylaxis/methods , Spinal Fusion/adverse effects , Spinal Injuries/surgery , Surgical Wound Infection/prevention & control , Vancomycin/therapeutic use , Adult , Anti-Bacterial Agents/administration & dosage , Female , Humans , Male , Middle Aged , Powders , Retrospective Studies , Surgical Wound Infection/drug therapy , Treatment Outcome , Vancomycin/administration & dosage
12.
13.
Tissue Eng Part A ; 16(7): 2369-79, 2010 Jul.
Article in English | MEDLINE | ID: mdl-20205517

ABSTRACT

Scaffolds prepared from biodegradable polyurethanes (PUR) have been investigated as a supportive matrix and delivery system for skin, cardiovascular, and bone tissue engineering. In this study, we combined reactive two-component PUR scaffolds with lovastatin (LV), which has been reported to have a bone anabolic effect especially when delivered locally, for effective bone tissue regeneration. To incorporate LV into PUR scaffolds, LV was combined with the hardener component before scaffold synthesis. The PUR scaffolds containing LV (PUR/LV) demonstrated a highly porous structure with interconnected pores, which supported in vitro cell attachment and proliferation and in vivo osteoconductive potential. The PUR/LV scaffolds showed sustained release of biologically active LV, as evidenced by the fact that LV releasates significantly enhanced osteogenic differentiation of osteoblastic cells in vitro. A study of bone formation in vivo using a rat plug defect model showed that the PUR/LV scaffolds were biocompatible. Further, locally delivered LV enhanced new bone formation in the PUR scaffolds at week 4, while there were no obvious effects at week 2. These results suggest that the sustained LV delivery system from PUR scaffolds is a potentially safe and effective device for bone regeneration.


Subject(s)
Biocompatible Materials/pharmacology , Bone Regeneration/drug effects , Elastomers/pharmacology , Lovastatin/pharmacology , Polyurethanes/pharmacology , Tissue Scaffolds/chemistry , Animals , Bone and Bones/cytology , Bone and Bones/drug effects , Cell Differentiation/drug effects , Delayed-Action Preparations , Kinetics , Male , Mice , Microscopy, Electron, Scanning , Osteogenesis/drug effects , Rats , Rats, Sprague-Dawley
15.
Spine (Phila Pa 1976) ; 31(23): 2735-41; discussion 2742-3, 2006 Nov 01.
Article in English | MEDLINE | ID: mdl-17077744

ABSTRACT

STUDY DESIGN: This is a retrospective study of 250 patients who describe low back pain with pain drawings. A computer application using artificial neural networks was designed to analyze pain drawings and evaluate the contribution of pain sensation to drawing classification. OBJECTIVE: The primary goal of this study was to assess the contribution of patient recorded pain sensation marks in classifying pain drawings into one of five broadly defined categories. The hypothesis was that including pain sensation would improve classification. SUMMARY OF BACKGROUND DATA: With no perfect diagnostic test for patients with low back pain, many approaches have been proposed and are used. One common diagnostic tool is the pain drawing. Several quantitative methods have been proposed to score the drawings. Some methods use pain sensation in the scoring; however, the contribution of pain sensation has not been defined. METHODS: A custom computer application classified the pain drawing. Data consisted of 250 pain drawings from patients with low back pain. RESULTS: Patient recorded pain sensation is not necessary in computer-based scoring of pain drawings. CONCLUSION: Patient-reported pain sensation does not improve classification when quantitatively scoring pain drawings.


Subject(s)
Diagnosis, Computer-Assisted , Low Back Pain/diagnosis , Low Back Pain/physiopathology , Medical Illustration , Neural Networks, Computer , Pain Measurement/methods , Pain Measurement/standards , Sensation , Humans , Low Back Pain/classification , Retrospective Studies
16.
J Orthop Res ; 23(2): 412-9, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15734256

ABSTRACT

PURPOSE: Recently, MMP-7 and MMP-3 have been found to play a crucial role in the natural resorption process of herniated discs. We therefore examined the role of these recombinant human matrix metalloproteinases (rh MMPs) in the treatment of herniated discs. METHODS: (a) Surgical samples of herniated disc were cultured in the presence or absence of rh MMPs, and wet weight was measured 24h later. (b) The rh MMPs were administered into normal rabbit intervertebral discs, and after 1 week spine samples were stained with Safranin O. (c) The rh MMPs were administered into canine herniated discs in vivo. Myelography and MRI were performed prior to and 1 week after administration. Spine samples were examined histologically. Whole disc tissue was collected, total protein was extracted, and Western blot analysis was performed. RESULTS: (a) Proteoglycan degradation was found in MMP-7, MMP-3, and chymopapain-treated samples. MMP-7 and chymopapain-treated samples displayed a significant loss in wet weight (p<0.01). (b) Normal disc tissues after administration of rh MMP-7, MMP-3, and chymopapain showed an extensive loss of Safranin O staining. (c) The rh MMP-7-treated discs had a marked decrease in protruded herniation by MRI. Herniated discs after administration of MMP-7 and chymopapain showed a significant decrease in protruded mass 7 days after administration compared with saline-treated discs when evaluated by myelography (p<0.01). The rh MMP-7-treated discs displayed a clear loss of Safranin O staining in the nucleus pulposus. Proteoglycan expression was barely detectable in disc tissues after MMP-7 administration, whereas obvious expression was obtained in saline-treated or untreated disc tissues. CONCLUSIONS: Exposure to rh MMP-7 resulted in promising proteoglycan loss in human surgical samples, normal rabbit intervertebral discs, and natural canine herniated discs. Administration of rh MMP-7 may facilitate the resorption process of herniated discs.


Subject(s)
Intervertebral Disc Displacement/drug therapy , Matrix Metalloproteinase 7/therapeutic use , Adult , Animals , Chymopapain/therapeutic use , Dogs , Humans , Intervertebral Disc/metabolism , Male , Matrix Metalloproteinase 3/therapeutic use , Matrix Metalloproteinase 7/pharmacology , Middle Aged , Organ Culture Techniques , Proteoglycans/metabolism , Rabbits , Recombinant Proteins/therapeutic use
18.
Spine (Phila Pa 1976) ; 28(22): 2546-50, 2003 Nov 15.
Article in English | MEDLINE | ID: mdl-14624093

ABSTRACT

STUDY DESIGN: A retrospective review of patient outcomes after lumbar spinal fusion. OBJECTIVE: To determine whether patients with a fusion ending adjacent to a "degenerated disc" (DDD group) had worse clinical outcomes than patients with fusions ending adjacent to "normal" discs (NL group). SUMMARY OF BACKGROUND DATA: Although it has been suggested that creating a rigid motion segment adjacent to a degenerated segment may negatively impact clinical outcomes after lumbar fusion, this question has not been addressed to our knowledge in the English literature. METHODS: Twenty-five consecutive patients treated with lumbar fusion for degenerative instability who had preoperative lumbar spine magnetic resonance imaging, who completed health status questionnaire Short Form 36 (SF-36), and were seen in the office for radiographic follow-up at least 2 years following surgical treatment formed the study group. The magnetic resonance images were reviewed independently by two spine surgeons and rated for the presence of any degenerative changes. Statistical analysis of the SF-36 data was performed with chi2 and Mann-Whitney U testing. RESULTS: Of the 25 patients, 20 were fused adjacent to at least one degenerated level (DDD group), whereas 5 were fused adjacent to a normal level (NL group). At follow-up, SF-36 scores were higher for the DDD group in all eight subgroups, contrary to the research hypothesis. A power analysis demonstrated with at least 98% certainty that if patients in the DDD group had even a 10% lower score in any of the 8 SF-36 subgroups, this study would have detected it. CONCLUSION: This retrospective review of patients who underwent lumbar fusion for degenerative instability demonstrated no adverse impact on clinical outcomes when the lumbar fusion ended adjacent to a degenerative motion segment. Although a power analysis validated these results with 98% certainty, larger prospective studies are needed to confirm that there is no benefit to include degenerated adjacent segments in a lumbar fusion for degenerative instability.


Subject(s)
Intervertebral Disc , Lumbar Vertebrae/surgery , Spinal Diseases/surgery , Spinal Fusion , Adult , Aged , Female , Health Status Indicators , Humans , Intervertebral Disc/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Retrospective Studies , Spinal Diseases/diagnosis , Treatment Outcome
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