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1.
Int J Impot Res ; 21(4): 221-7, 2009.
Article in English | MEDLINE | ID: mdl-19474796

ABSTRACT

Premature ejaculation (PE) is thought to be the most common male sexual dysfunction; however, the prevalence of lifelong (LL)-PE is relatively low. The aim of this study was to investigate the effects of on-demand vardenafil (10 mg) to modify the intravaginal ejaculatory latency time (IELT) in men with LL-PE without erectile dysfunction. Forty-two men (18-35 years) were enrolled in a 16-week, double-blind, placebo-controlled, cross-over study. Primary end point was the modification from baseline of IELT assessed by stopwatch technique; secondary end points were post-ejaculatory refractory time (PERT) and variations of scores at the Index of Premature Ejaculation questionnaire. The changes in geometric mean IELT were superior after taking vardenafil (0.6+/-0.3 vs 4.5+/-1.1 min, P<0.01), compared with placebo (0.7+/-0.3 vs 0.9+/-1.0 min, ns). PERT dropped significantly after vardenafil (16.7+/-2.0 vs 4.3+/-0.9 min, P<0.001), compared with placebo (15.3+/-2.2 vs 15.8+/-2.3 min). Patients who took vardenafil (vs placebo) reported significantly (P<0.01) increased ejaculatory control (6+/-2 vs 16+/-2), improved overall sexual satisfaction (7+/-2 vs 15+/-1) and distress (4+/-1 vs 8+/-1) scores, respectively. Multiple regression analysis (r(2)=0.86) for IELT by the number of attempts at sexual intercourse showed significant differences between the slopes of lines for placebo and vardenafil (P<0.0001). The most common adverse events for vardenafil (vs placebo) were headache (10 vs 3%), flushing (12 vs 0%) and dyspepsia (10 vs 0%), which tended to disappear over the time. In conclusion, in our study, vardenafil increased IELT and reduced PERT in men with LL-PE. Besides, improvements in confidence, perception of ejaculatory control and overall sexual satisfaction were reported.


Subject(s)
Ejaculation/drug effects , Imidazoles/therapeutic use , Phosphodiesterase Inhibitors/therapeutic use , Piperazines/therapeutic use , Sexual Dysfunction, Physiological/drug therapy , Adolescent , Adult , Coitus/physiology , Coitus/psychology , Cross-Over Studies , Double-Blind Method , Female , Humans , Imidazoles/administration & dosage , Imidazoles/adverse effects , Male , Phosphodiesterase Inhibitors/adverse effects , Piperazines/administration & dosage , Piperazines/adverse effects , Prospective Studies , Sexual Dysfunction, Physiological/psychology , Sulfones/administration & dosage , Sulfones/adverse effects , Sulfones/therapeutic use , Surveys and Questionnaires , Triazines/administration & dosage , Triazines/adverse effects , Triazines/therapeutic use , Vardenafil Dihydrochloride , Young Adult
2.
Oral Implantol (Rome) ; 1(1): 15-20, 2008 Apr.
Article in English | MEDLINE | ID: mdl-23285332

ABSTRACT

OBJECTIVE: compare the values of the Bennett angle measured by an average value articulator with the ones measured by a 64 slices Computed Tomography (CT). METHODS: we have studied a patient aged 72. Maxillary and mandibular impressions were obtained from the patient and placed on the average value articulator using wax-ups and a facial arch in order to perform the Bennett angle measurations by such device. CT measurements were carried out using templates in order to block the Patient in the correct mandibular position. RESULTS: our study has demonstrated that the measurements of the Bennett angle obtained with the average value articulator are consistent with the ones obtained with the 64 slices CT. CONCLUSIONS: CT scanning is a useful method, alternative to conventional procedures, as the average value articulator for Bennett angle measurements, and it could become an important diagnostic tool in the gnathological and rehabilitative area.

3.
Urologia ; 75(1): 24-31, 2008.
Article in Italian | MEDLINE | ID: mdl-21086372

ABSTRACT

This is an open, multicentre, randomized, crossover study having the aim to evaluate the preference for sildenafil citrate or tadalafil in a population of Italian patients affected by ED, and to compare the efficacy and safety of these two drugs. MATERIAL AND METHODS. From October 2003 to November 2004, thirteen Italian centers enrolled ED patients (age >18) being in steady and naïve relation to ED treatment, both through PDE5 inhibitors and any other treatment option. These patients were randomized to sildenafil or tadalafil for 12 weeks, after which they were switched to the alternative treatment for a further 12 weeks. The preference was evaluated through the Treatment Preference Question (TPQ): "During this clinical trial you have taken tadalafil and sildenafil for the treatment of erectile dysfunction. Which medication do you prefer to take for the next 8 weeks of treatment?". Moreover, patients were asked to express their preference as "strong" or "moderate" and to answer some questions to clarify the reasons behind their preference. SEP and IIEF-EF questionnaires were used for a comparison of efficacy. RESULTS. 167 patients were enrolled, 144 of whom completed both treatment periods. On being asked the TPQ, 75% of patients (n=108) decided to continue treatment with tadalafil, in particular because it made it possible to have an erection many hours after taking the medication (first or second preference reason for 64.8% of patients), while 25% (n=36) preferred sildenafil (p=0.001). Both drugs improved the IIEF-EF and SEP scores compared to baseline, with a slightly but significantly greater improvement with tadalafil for both parameters. CONCLUSIONS. Tadalafil and sildenafil are both effective and well tolerated. Most of the patients prefer tadalafil thanks to the possibility of having sexual intercourse many hours after taking the medication.

4.
Neurology ; 65(6): 919-21, 2005 Sep 27.
Article in English | MEDLINE | ID: mdl-16051646

ABSTRACT

The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.


Subject(s)
Cerebral Arteries/drug effects , Cerebrovascular Circulation/drug effects , Phosphodiesterase Inhibitors/adverse effects , Piperazines/adverse effects , Aged , Brain Ischemia/chemically induced , Brain Ischemia/physiopathology , Cerebral Arteries/diagnostic imaging , Cerebral Arteries/physiology , Cerebrovascular Circulation/physiology , Dose-Response Relationship, Drug , Double-Blind Method , Endothelial Cells/drug effects , Endothelial Cells/metabolism , Humans , Male , Middle Aged , Migraine Disorders/chemically induced , Migraine Disorders/physiopathology , Phosphodiesterase Inhibitors/administration & dosage , Piperazines/administration & dosage , Placebos , Purines , Sildenafil Citrate , Sulfones , Time Factors , Ultrasonography, Doppler, Transcranial , Vasodilation/drug effects , Vasodilation/physiology
5.
J Endocrinol Invest ; 27(2): 192-206, 2004 Feb.
Article in English | MEDLINE | ID: mdl-15129818

ABSTRACT

In the last few years the pathophysiological mechanisms of erection have been partially clarified, and the molecular machinery of the cellular components of the corpus cavernosum (CC) has been widely investigated. Since erection is a vascular event and the penis is a vascular organ, there must be an intact endothelium for an erection to occur. The regulation of penile tumescence inside the CC involves a balance between contracting and relaxing factors which regulate the functional state of smooth muscle cells. Recent studies have highlighted the importance of new local factors (i.e. phosphodiesterases, rho-kinases and endothelins), and pharmacological agents are available in the armamentarium of the specialist which are targeted to modulate the function of those mediators of erection. It is now well understood that male erectile dysfunction (ED) is a symptom rather than a disease; for this reason in the near future both general practitioners and specialists in internal medicine would have to interplay with sexual medicine. This review is intended to give the clinician some basic concepts of the pathophysiology of erection with relevance to the clinical practice, and to discuss the newest therapeutic approaches for those patients who do not respond to the treatment with oral inhibitors of phosphodiesterase Type 5.


Subject(s)
Erectile Dysfunction/physiopathology , Phosphodiesterase Inhibitors/pharmacology , Phosphoric Diester Hydrolases/drug effects , 3',5'-Cyclic-GMP Phosphodiesterases , Cyclic Nucleotide Phosphodiesterases, Type 5 , Erectile Dysfunction/complications , Erectile Dysfunction/drug therapy , Humans , Male , Penile Erection/drug effects , Phosphodiesterase Inhibitors/therapeutic use , Quality of Life
6.
J Endocrinol Invest ; 26(3 Suppl): 132-6, 2003.
Article in English | MEDLINE | ID: mdl-12834040

ABSTRACT

The recent development of new medications for the treatment of the sexual dysfunction increased the possibility of improving the altered sexual performance. Although initially designed for the treatment of male sexual dysfunction, erectile dysfunction in particular, these substances have now been tested for the therapy of a broad range of sexual dysfunction also in the female. Here we will briefly review the therapeutic options currently available and the potential of new pharmacological treatments for male and female sexual dysfunction.


Subject(s)
Sexual Dysfunction, Physiological/drug therapy , Female , Humans , Iatrogenic Disease , Male , Sexual Dysfunction, Physiological/diagnosis , Sexual Dysfunction, Physiological/etiology
10.
Tórax ; 28(2/3): 41-3, 1982.
Article in Spanish | LILACS | ID: lil-13719

ABSTRACT

La hipertension arterial (HTA) como una de las causas de muerte e invalidez mas importante de caso todo el mundo ha sido motivo de intensas investigaciones en los ultimos anos, tratando de esclarecer su etiologia asi como su fisiopatoligia a los efectos de orientar nuevas medidas profilacticas y terapeuticas, con mayor y mejor expectativa de vida para el paciente hipertenso. Aproximadamente el 15% de la poblacion general sufre hipertension arterial y este numero puede llegar al 40% entre los mayores de 40 anos


Subject(s)
Adult , Middle Aged , Humans , Male , Female , Pindolol , Clopamide , Hypertension , Drug Combinations , Heart Rate
12.
Arch Inst Cardiol Mex ; 45(3): 301-6, 1975.
Article in English | MEDLINE | ID: mdl-1156004

ABSTRACT

The intramyocardial PO2 was studied in 7 patients after cardiac surgery, by means of a long-term electrode implanted subepicardically in the free wall of the left or the right ventricle, utilizing the polarographic method. Inhalation of 100% O2 or 5% CO2 +95% O2 provoked maximal increases in the myocardial PO2. In most cases intense exercise, and the Valsalva manoeuvre caused a decrease in the PO2. Intravenous propranolol slightly increased the PO2 in one case. Other drugs used in coronary patients caused inconstant effects. Sleeping decreased the heart PO2 in one case. This technique appears to be a useful tool for studying the human intramyocardial PO2 during a period of several weeks.


Subject(s)
Heart Failure/metabolism , Myocardium/metabolism , Oxygen Consumption , Adolescent , Adult , Amyl Nitrite/pharmacology , Dipyridamole/pharmacology , Electrocardiography , Electrodes, Implanted , Heart Failure/therapy , Humans , Hypoxia , Injections, Intravenous , Isosorbide Dinitrate/pharmacology , Oxygen/analysis , Oxygen Consumption/drug effects , Oxygen Inhalation Therapy , Papaverine/pharmacology , Partial Pressure , Physical Exertion , Posture , Sleep , Valsalva Maneuver
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