Use of functionalized nanosilica to improve thermo-mechanical properties of epoxy adhesive joint bonding aluminium substrates.

The present work is concerned with the improvement of thermal properties and mechanical strength of adhesive joints consisting of an epoxy adhesive layer bonding aluminium substrates by grafted nanosilica. Epoxy resin/silica nanocomposites were prepared by using functionalized silica. Silica was functionalized by amine group (SiO2-NH2). It was identified by Raman and Fourier Transform Infrared (FTIR). Effects of silica on viscoelastic properties for epoxy resin and its assemblies with aluminium substrates were studied by Dynamical Mechanical Analysis (DMA). Particles distribution was characterized by Scanning Electron Microscope (SEM). Our experimental results showed that functionalized silica presents a better distribution in the matrix than the pure silica. Our results also showed that grafting of functionalized silica improves the glass transition temperature (Tg) and the ultimate strength of aluminium/epoxy/aluminium assembly.

Inhibition of human breast cancer cell growth by blockade of the mevalonate-protein prenylation pathway is not prevented by overexpression of cyclin D1.

Overexpression of the cyclin D1 (CCND1) gene, encoding a downstream effector of mitogenic signals that plays a central role in G1 phase progression, is often found in cancerous cells. In sporadic breast cancer (BC), this is one of the most frequent and early genetic lesions identified so far, found in more than 50% of the tumors. Inhibitors of the mevalonate/protein prenylation pathway belong to a new family of cancer therapeutic agents that act by blocking intracellular mitogenic signal transduction pathways, thereby preventing expansion of pre-cancerous foci and inhibiting growth of transformed cells. It is not known at present whether constitutively high intracellular levels of cyclin D1 might interfere with the cytostatic actions of mevalonate/protein prenylation inhibitors. This possibility was investigated here by assessing the cell cycle effects of Simvastatin, a non-toxic upstream inhibitor of the mevalonate pathway, on human BC MCF-7 cells expressing either normal or enhanced levels of cyclin D1 from of a stably transfected, tet-inducible expression vector. Results show that constitutive overexpression of this protein, such as that found in sporadic BCs, does not influence the growth inhibitory effects of Simvastatin in vitro. In addition, D1-overexpressing embryo fibroblasts were also found to be responsive to the cell cycle effects of mevalonate/protein prenylation pathway blockade, further suggesting that high intracellular levels of cyclin D1 do not prevent the cytostatic actions of compounds targeting this metabolic pathway.

Anatomical basis for congenital deformities of the lower extremities. Part III. The foot and ankle.

The human foot has been characterized as a miracle of engineering and mechanical efficiency. It is a complex organ, both physiologically and structurally. The authors present a study of the foot and ankle with emphasis on the anatomy of midterm fetuses as revealed by cryomicrotomy.