[Methods of treatment of acute hepatic insufficiency with isolated hepatocytes]. / Sposoby primeneniia izolirovannykh gepatotsitov dlia lecheniia ostroi pechenochnoi nedostatochnosti.

The paper describes different methods for using isolated hepatocytes to compensate hepatic dysfunctions and to treat hepatic failure. Most of them are safe and produce no complications if isolated hepatocytes are separated from blood with the semipermeable membrane. The survival and functional activity of isolated hepatocytes transplanted into different places and organs are ambiguous and unequal in terms of efficiency. Search for a rational and optimal method for implantation of isolated hepatocytes, for conditions for their functioning, for combinations of different cells, for proliferation of the implanted cells is a subject of special interest and it is in progress. Many procedures have been experimentally justified and are being now used clinically to treat hepatic failure in various hepatic diseases.

[Development of an experimental multichannel equipment complex for controlling bioelectric processes in the stomach and intestines]. / Razrabotka éksperimental'nogo mnogokanal'nogo kompleksa priborov dlia kontrolia bioélektricheskikh protsessov zheludka i kishechnika.

The multichannel informative set of devices provides high-fidelity recording of bioelectric potentials from the human anterior abdominal wall to examine the activity of the stomach and the small and large intestine.

[Liver regeneration in mice after a partial hepatectomy under the action of blood serum and of an extract of cirrhotically altered human liver]. / Regeneratsiia pecheni myshei posle chastichnoi gepatéktomii pod deistviem syvorotki krovi i ékstrakta tsirroticheski izmennoi pecheni cheloveka.

The effects of blood serum and liver extracts from patients with chronic active hepatitis and liver cirrhosis on the mitotic rate of the mouse liver regenerating after partial hepatectomy were comparatively studied. It is suggested that the livers of patients suffering from active cirrhosis produce a factor which is capable of stimulating the mitotic activity of hepatocytes.

[Liver chalones]. / O keilonakh pecheni

Administration of a liver extract and the blood serum of adult intact mice and also of the blood serum of practically healthy persons to CBA X C57B1 hybrid mice produced a sharp depression of the mitotic activity of hepatocytes in the regenerating liver after its partial removal. The extract of the regenerating liver and the blood serum of the animals with the regenerating liver failed to depress mitoses in hepatocytes. The blood serum of man with the postnecrotic active cirrhosis of the liver not only failed to depress mitoses in the hepatocytes, but even caused an increase in their count. It is supposed that there was a reduction of the chalone concentration in the cirrhotic liver.