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Clin Ther ; 10(1): 32-5, 1987.
Article in English | MEDLINE | ID: mdl-3450393

ABSTRACT

The therapeutic role of naloxone was examined in a pilot study of 23 patients with hepatic (portal-systemic) encephalopathy. The results indicate that endogenous opioids (endorphins, enkephalins) are involved in the pathogenesis of hepatic encephalopathy. It is concluded that naloxone, a relatively pure opioid antagonist, may be an effective and well-tolerated drug for this particular pathology.


Subject(s)
Hepatic Encephalopathy/drug therapy , Naloxone/therapeutic use , Drug Administration Schedule , Drug Evaluation , Female , Humans , Infusions, Intravenous , Male , Middle Aged , Naloxone/administration & dosage , Pilot Projects
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