ABSTRACT
In experiment with rats it was found that the "energy" Pu is more toxic than standard 239Pu when entered endotracheally. The comparison was made by the non-stochastic effects. The toxicity in respiratory system and blood system was 1.8 and 1.6 times higher when calculated per 1sGy of absorbed dose and 1.6 and 1.1 times higher when calculated per 1kBg/kg of the amount taken, respectively.
Subject(s)
Plutonium/toxicity , Americium/toxicity , Animals , Blood Cells/radiation effects , Bone and Bones/radiation effects , Data Interpretation, Statistical , Liver/radiation effects , Lung/radiation effects , Male , Models, Biological , Radiation Dosage , Rats , Rats, WistarABSTRACT
It has been established in experiments on rats that under combined inhalation exposure to 239Pu along with TBP and HCLB in amounts which may cause the changes in blood and immune systems the enhancing of different non-stochastic effects on the average by two times on a basis of a unit absorbed dose in comparison with isolated nuclide inhalation.
Subject(s)
Butadienes/pharmacology , Erythrocytes/drug effects , Immune System/drug effects , Leukocytes/drug effects , Organophosphates/pharmacology , Plutonium , Radiation-Protective Agents/pharmacology , Animals , Drug Interactions , Erythrocytes/radiation effects , Immune System/radiation effects , Inhalation , Leukocytes/radiation effects , Male , Models, Biological , Rats , Rats, WistarABSTRACT
It has been established in the experiment on rats exposed to a joint action of plutonium-239, hexachlorobutadiene and ++tributyl phosphate, that manifestations of disturbances from radiation and chemical factors which are more expressed under a joint exposure, are characteristic of the thymus gland damage pattern. As far as lymphocytes count in the organ is concerned, the effect of the joint exposure is no more than additive.
Subject(s)
Butadienes/adverse effects , Fungicides, Industrial/adverse effects , Organophosphates/adverse effects , Plutonium/adverse effects , Radiation Injuries, Experimental/etiology , T-Lymphocytes/radiation effects , Thymus Gland/injuries , Thymus Hyperplasia/chemically induced , Animals , Butadienes/administration & dosage , Leukocyte Count/drug effects , Leukocyte Count/radiation effects , Organophosphates/administration & dosage , Radiation Injuries, Experimental/pathology , Rats , Rats, Inbred Strains , T-Lymphocytes/drug effects , T-Lymphocytes/pathology , Thymus Gland/drug effects , Thymus Gland/radiation effects , Thymus Hyperplasia/pathologyABSTRACT
Under the combined effect of external gamma-irradiation and 239Pu, osteosarcomas occur more frequently and at earlier times, and have more pronounced multicentric pattern of growth and metastatic spreading than occurs with the two agents delivered separately. The difference is in the increased development of tumors and the decreased osteogenesis. Tumor carriers develop atrophy of thymus lymphoid tissue more frequently than normal ones.
