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1.
Rozhl Chir ; 102(1): 32-36, 2023.
Article in English | MEDLINE | ID: mdl-36809893

ABSTRACT

Diverticulitis of the ileum is an inflammatory complication of diverticulosis. It is an uncommon cause of acute abdomen that can have a very serious course, leading, for example, to intestinal perforation or bleeding. Imaging findings are very often negative and the true cause of the condition is only revealed peroperatively. In this case report, we present a case of perforated ileal diverticulitis in a patient with bilateral pulmonary embolism. This was the main reason for conservative management in the first period of time. After resolution of the pulmonary embolism, resection of the affected bowel segment was performed at the time of the next attack.


Subject(s)
Abdomen, Acute , Diverticulitis , Intestinal Perforation , Humans , Diverticulitis/diagnosis , Ileum/surgery , Abdomen, Acute/complications , Intestinal Perforation/etiology , Diagnosis, Differential
2.
Acta Chir Orthop Traumatol Cech ; 87(4): 251-258, 2020.
Article in Czech | MEDLINE | ID: mdl-32940220

ABSTRACT

PURPOSE OF THE STUDY This study is a component part of the project focused on cartilage imaging after the treatment of a defect. It aims to compare the evaluation of postoperative status performed by two radiologists with the use of 2D MOCART scoring system and to determine whether this method is a reliable tool for the evaluation of postoperative changes. MATERIAL AND METHODS The study evaluated 78 MRI examinations from 25 patients (one patient had two defects treated), each of whom underwent 3 MRI examinations at 6, 12 and 18 months after surgery. The MRI examinations were performed on Philips Ingenia 3T scanner with 8-channel knee coil, in line with the routine protocol (coronal, sagittal and transversal PD SPAIR, coronal T1, sagittal PD HR, sagittal bFFE). The MRI examinations were evaluated independently by two radiologists using the 2D MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) score. RESULTS The raters agreed in a total of 592 of 702 evaluations, therefore the inter-rater reliability is high, namely 84.3%. The highest inter-rater agreement was in assessing subchondral lamina and subchondral bone. Whereas the lowest inter-rater agreement was achieved in assessing effusion. The total score showed a very strong and statistically significant correlation (r = 0.893). In eight out of nine questions there was no statistically significant difference between the raters. A significant difference was seen only in the assessment of repair tissue structure. Excellent reliability of the total score was also confirmed by the intraclass correlation coefficient. DISCUSSION The high degree of agreement in assessing the signal intensity of repair tissue was considered very positive as it is generally viewed as the major pitfall in evaluations. On the contrary, subjective perception was confirmed in the evaluation of tissue homogeneity, especially when comparing homogeneity with the adjacent tissue in close vicinity that could have changed already. Surprisingly, the lowest inter-rater concordance was reported in the evaluation of effusion, where in some cases, its volume was underestimated, when traced back retrospectively. CONCLUSIONS The results of this study confirm that despite certain doubts regarding subjective perception of some of the evaluation criteria the 2D MOCART scoring system is a very good and objective tool to evaluate the effects of surgery. Key words: magnetic resonance imaging , hyaline cartilage, classification.


Subject(s)
Cartilage, Articular , Cartilage, Articular/diagnostic imaging , Cartilage, Articular/surgery , Humans , Knee Joint/diagnostic imaging , Knee Joint/surgery , Magnetic Resonance Imaging , Reproducibility of Results , Retrospective Studies
3.
Acta Chir Orthop Traumatol Cech ; 87(3): 167-174, 2020.
Article in Czech | MEDLINE | ID: mdl-32773017

ABSTRACT

PURPOSE OF THE STUDY Damage to hyaline cartilage represents a serious problem due to its limited capacity of regeneration. Currently, there are several treatment options available. The purpose of this study is to evaluate the success rate of treatment of chondral and osteochondral defects of the knee joint using the modified AMIC (Autologous Matrix-Induced Chondrogenesis) technique, combining microfractures of the base and the implantation of the type I collagen-based cell-free implant over a two-year period. MATERIAL AND METHODS The prospective study of the success rate of treatment by the modified AMIC technique included 15 patients (13 men and 2 women) with a defect confirmed by MRI and appropriate indication criteria. The mean age at the time of implantation was 33.4 years (range 19-47 years). The mean size of a treated defect was 3.66 ± 1.71 cm2 (range 2.00-7.05 cm2). The clinical outcomes were monitored through the Knee Injury and Osteoarthritis Outcome Score (KOOS), the Lysholm score and the Tegner activity scale preoperatively and subsequently at 6, 12 and 24 months postoperatively. Control MRI was conducted at 6, 12 and 18 months postoperatively. The MRI finding was evaluated using the Magnetic Observation of Cartilage Repair Tissue (MOCART) score. RESULTS The total KOOS score was 44.69 ± 7.71 preoperatively, while postoperatively it gradually increased up to 80.45 ± 8.97 (p < 0.001) at 24 months. The Lysholm score significantly rise from 43.47 ± 11.87 preoperatively to the mean value of 81.60 ± 13.07 (p < 0.001) at 24 months postoperatively. The preoperative Tegner score was 3.53 ± 1.41. At 24 months, there was a statistically significant increase to 5.40 ± 1.70 (p = 0.003). The mean MOCART score at 18 months postoperatively was 74.67 ± 14.08. At the end of the monitored period, a complete filling of the defect site by tissue was achieved in 73.33% patients. A complete integration with adjacent cartilage was seen in 66.67% patients and homogenous structure of newly formed tissue was reported in 80% of patients. DISCUSSION In recent years, cell-free implants (the so-called scaffolds or carriers) have been used ever more frequently in treating localised cartilage defects. Their main effect should consist in helping the cells penetrate the defect site and support new cartilage tissue formation. In order to improve the efficacy of cell-free implants, a new therapeutic technique was developed, combining the microfractures of the base with the use of cell-free scaffold AMIC (Autologous Matrix-Induced Chondrogenesis). Our modification of the original AMIC technique consists in the use of a type I collagen-based scaffold instead of the original collagen membrane constituted by collagen type I and III. Based on the statistical processing of results, the modified AMIC technique has shown a statistically significant improvement compared to the preoperative values of the KOOS questionnaire and all its sub-groups, the Lysholm core and the Tegner activity scale. These good clinical outcomes correlate with the results obtained by other authors using both the original method and the modified AMIC technique. CONCLUSIONS The modified AMIC technique using the cell-free type I collagen-based implant appears to be a safe, accessible and onestage technique to treat localised chondral and osteochondral defects of the knee joint up to the size of 8 cm2. Key words: hyaline cartilage, chondral defect, AMIC, scaffold, knee.


Subject(s)
Cartilage, Articular , Adult , Cartilage, Articular/diagnostic imaging , Cartilage, Articular/surgery , Chondrogenesis , Female , Follow-Up Studies , Humans , Knee Joint/diagnostic imaging , Knee Joint/surgery , Magnetic Resonance Imaging , Male , Middle Aged , Prospective Studies , Transplantation, Autologous , Treatment Outcome , Young Adult
4.
Acta Chir Orthop Traumatol Cech ; 85(5): 366-369, 2018.
Article in Czech | MEDLINE | ID: mdl-30383534

ABSTRACT

The authors present an overview of the commonly used techniques and new trends of the cartilage imaging, especially postoperatively, and also discuss the potential of MRI imaging of the cartilage from the perspective of an experienced orthopaedic surgeon. In conclusion, the authors propose possible explanations for the potential discrepancies between the MRI and the arthroscopic findings. Hyaline cartilage damage and subsequent reparation of this tissue is one of the topical issues of orthopaedics and traumatology. Due to the expanding possibilities of treatment of this tissue and a relatively good effect of the surgery, the number of patients indicated for magnetic resonance imaging prior to the surgery has been on an increase. To make a decision concerning the subsequent type of treatment, it is necessary to get an idea of the cartilage cover condition, articular surfaces and also of the associated pathologies. The degree of cartilage damage can be assessed by arthroscopy or magnetic resonance imaging, which provides also the possibility of the subchondral lesion detection. Thanks to the noninvasive nature of the MRI examination, it has become the most important method in full imaging of the articular cartilage. The MRI of the cartilage has many options and at present the evaluation of the hyaline cartilage should be an integral part of each MRI examination of joints. For a more accurate assessment of the cartilage there are several advanced techniques available that can be used not only for preoperative diagnostics, but also for monitoring after the surgery. Key words: hyaline cartilage, magnetic resonance, arthroscopy.


Subject(s)
Cartilage, Articular/diagnostic imaging , Hyaline Cartilage/diagnostic imaging , Knee Joint/cytology , Arthroscopy/methods , Cartilage, Articular/pathology , Decision Making/ethics , Humans , Hyaline Cartilage/pathology , Knee Joint/surgery , Magnetic Resonance Imaging/methods , Magnetic Resonance Imaging/standards , Orthopedic Surgeons , Postoperative Period , Preoperative Care/standards , Radiologists
5.
Acta Chir Orthop Traumatol Cech ; 85(2): 89-93, 2018.
Article in Czech | MEDLINE | ID: mdl-30295593

ABSTRACT

PURPOSE OF THE STUDY The Growth Guidance System (GGS) represent a relatively new alternative to the traditional growing systems used for the treatment of early onset scoliosis. Ranking among the main aims of this surgical treatment is a three-dimensional correction of the deformity, maintenance of spinal growth and postponement of the necessity of final treatment by spondylodesis. MATERIAL AND METHODS Our study retrospectively evaluates the results of surgical correction in a group of 35 patients treated by GGS technique. The group consisted of patients with idiopathic, neuromuscular and syndromic spine deformity with the average age of 8 years and 2 months at the time of the surgery. The time of the follow-up is 3 years and 5 months on average. We evaluated the correction of the curve itself, the growth of the spine measured in the thoracic and lumbar part separately, and the growth of the trunk as a whole in the mentioned range on X-ray pictures. RESULTS The average correction of the scoliotic curve was 67%, from 75 preoperative degrees to 20 postoperative degrees. After the first operation 11% elongation of the trunk (from 321 mm to 356 mm) was reached, the thoracic spine was elongated by 10% (from 196 to 217 mm) and the lumbar spine was elongated by 11% (from 125 to 139 mm). The elongation of the trunk by 16% (from 322 to 375 mm) was observed in the cohort of patients with two years postoperative follow-up (21 patients). The total protraction of the trunk by 21% (from 318 to 386 mm) was reached in patients treated by definitive fusion (7 patients). DISCUSSION There is a very low number of studies analysing the long-term clinical results with the use of GGS. The first pilot results indicate that it is a technique allowing to achieve at least comparable results in correction of frontal plane compared with the distraction type of instrumentations. A negative aspect of this method is the abrasion of metal followed by metallosis. The new types of fixation screws enable more effective sliding of rods, maintenance of continuity of body grow by the shifting of rods as well as lower abrasion of the instrumentation. CONCLUSIONS The main advantage of GGS is the limited continuous growth of the spine, partial three-dimensional correction of the deformity, minimisation of inevitable reoperations under general anaesthesia and the possibility to quit a brace. Key words: growth guided system, early onset scoliosis, distraction, spinal growth, spondylodesis.


Subject(s)
Lumbar Vertebrae/diagnostic imaging , Lumbar Vertebrae/growth & development , Scoliosis/diagnostic imaging , Scoliosis/surgery , Spinal Fusion , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/growth & development , Age of Onset , Child , Follow-Up Studies , Humans , Internal Fixators , Lumbar Vertebrae/surgery , Radiography , Retrospective Studies , Scoliosis/physiopathology , Spinal Fusion/instrumentation , Thoracic Vertebrae/surgery , Torso/diagnostic imaging , Torso/growth & development , Treatment Outcome
6.
Acta Chir Orthop Traumatol Cech ; 85(3): 194-198, 2018.
Article in Czech | MEDLINE | ID: mdl-30257778

ABSTRACT

PURPOSE OF THE STUDY Neuromuscular deformities of the spine represent surgically uneasy to solve problems as well as serious handicaps causing sitting instability, pressure ulcers as well as pain. The aim of our study is to conduct a retrospective clinical analysis of the results of surgical correction of these deformities. This paper presents the use of a recent technique of sacral-alar-iliac (S2AI) screws and its comparison with other techniques of pelvic stabilisation. MATERIAL AND METHODS The group of 41 patients treated surgically with S2AI screws technique and transpedicular or hybrid instrumentation of the spine consisted of patients with the primary diagnosis of muscular dysthrophy, spinal muscular atrophy, cerebral palsy and some other neuromuscular diseases. The results of pelvic obliquity correction and scoliotic correction in combined neuromuscular deformities of the spine and pelvis were analysed. The technique of S2AI screws implantation and the possibility of their free-hand technique implementation were presented. RESULTS In the followed-up group of patients an average correction of pelvic obliquity by 81% (from 29.1 degrees before the operation to 5.6 degrees after the operation) was reported. On average, 74% correction of scoliotic spine deformity was achieved (from 83.3 degrees before the operation to 22.5 degrees after the operation). In both the cases neither a significant loss of correction at the minimum one-year follow-up nor any serious complications associated with grappling of pelvic fixation were observed. DISCUSSION The S2AI screws offer at least the same stability and ability of correction as iliac screws and at the same time they provide significantly better results compared with the older methods of pelvic fixation such as the Galvestone technique. With a good knowledge of the surgical technique and anatomical aspects this technique can be applied in the form of a free-hand technique. Navigation as well as robotic techniques can help with the accurate positioning of the S2AI screw. Transfixation of sacroiliacal syndesmosis in patients with a neuromuscular handicap does not lead to deterioration of their mobility. CONCLUSIONS Simultaneous stabilisation of spine and pelvis makes it possible to achieve a good quality correction of the deformity and good clinical results over a long period of time. It allows for stability of the sitting position of the patients and improves the quality of their lives. Nowadays, the S2AI screws are considered to be biomechanically the best quality pelvic fixation, eliminating subcutaneous prominence of the instrumentation and reducing the risk of skin decubitus. Key words:neuromuscular deformity, sacral-alar-iliac screw, pelvic obliquity, stabilization, scoliosis.


Subject(s)
Bone Screws , Pelvic Bones/surgery , Postoperative Complications , Pressure Ulcer , Spinal Curvatures , Spinal Fusion , Adolescent , Female , Humans , Male , Neuromuscular Diseases/complications , Outcome Assessment, Health Care , Pelvic Bones/pathology , Postoperative Complications/diagnosis , Postoperative Complications/etiology , Postoperative Complications/prevention & control , Pressure Ulcer/diagnosis , Pressure Ulcer/etiology , Pressure Ulcer/prevention & control , Range of Motion, Articular , Spinal Curvatures/diagnosis , Spinal Curvatures/etiology , Spinal Curvatures/physiopathology , Spinal Curvatures/surgery , Spinal Fusion/adverse effects , Spinal Fusion/methods
7.
Acta Chir Orthop Traumatol Cech ; 85(3): 209-215, 2018.
Article in Czech | MEDLINE | ID: mdl-30257781

ABSTRACT

INTRODUCTION The authors evaluate the results of endoscopic treatment and analyse the causes of persisting difficulties in retrocalcaneal bursitis unresponsive to conservative treatment. Stated as one of the causes is the possible chronic irritation of minor/partial tears of anterior parts of the distal portion of the Achilles tendon, which have no chance to heal due to continued overload and impingement syndrome of the superior prominence of the calcaneal tubercle. MATERIAL AND METHODS The authors evaluate the group of 24 patients (10 women and 14 men) diagnosed with retrocalcaneal bursitis, who reported more than 12 months of difficulties and in whom the conservative therapy options have already been exhausted. The decision to perform a revision arthroscopy was made by the authors based on chronic long-lasting difficulties, clinical examination, calcaneus radiograph, ultrasound examination and negative response to the performed conservative treatment. The MRI scan was obtained in 4 patients. In 11 patients during arthroscopy the Achilles tendon was intact, in 13 patients (54.2%) minor tears were detected on the anterior aspect of the distal Achilles tendon, not diagnosed preoperatively (by ultrasound examination). In all the patients, resection of the prominence of the calcaneal tubercle was performed, whereas in patients with affected Achilles tendon also the loose tendon fragments were resected. RESULTS A total of 23 patients reported an improvement of their condition, the pain subsided at 21-43 days. Altogether 21 patients returned to activities carried out before the onset of pain. The AOFAS score values measured preoperatively in patients with an intact tendon were 59.5 ± 15.0, in patients with an injured tendon it was 45.57 ± 9.6, while 6 months after the surgery the values were 95.7 ± 6.2, or 88.71 ± 7.8 respectively. In 1 female patient, with one prior surgery, diagnosed with a partial tear of the Achilles tendon, the effect of the surgery was unsatisfactory. After six months the patient underwent an open revision surgery and the Achilles tendon reinsertion. No intraoperative or postoperative complications were observed. DISCUSSION The endoscopic technique facilitates a more visible bone resection, with better control of resection, which is less invasive than the open technique. The source of irritation can be removed, which is not always only the prominence of the calcaneal tubercle, but another cause of persisting problems can also be a microtrauma affecting the anterior portion of the Achilles tendon, with a reactive hyperaemia in bursal tissue. Compared to literature and also based on the results of the authors of this retrospective study, the endoscopic calcaneoplasty is less invasive than the open surgery. It is always necessary to properly diagnose the causes of difficulties and to timely respond to persisting symptoms in patients, not responding satisfactorily to conservative therapy. CONCLUSIONS The findings presented by the authors provide a new perspective on the causes of chronic problems such as the "posterior heel pain" and tend to give preference to the active endoscopic approach in patients with persisting problems, not responding to conservative treatment, predisposed based on the radiological examination and with a positive finding on ultrasound or MRI scan. Key words:retrocalcaneal bursitis, endoscopic calcaneoplasty, arthroscopy.


Subject(s)
Arthroscopy , Achilles Tendon/injuries , Arthroscopy/adverse effects , Arthroscopy/methods , Bursitis/diagnosis , Bursitis/physiopathology , Bursitis/surgery , Calcaneus/diagnostic imaging , Calcaneus/pathology , Female , Humans , Magnetic Resonance Imaging/methods , Male , Middle Aged , Outcome Assessment, Health Care , Pain, Postoperative/diagnosis , Pain, Postoperative/etiology , Pain, Postoperative/surgery , Radiography/methods , Reoperation/methods , Reoperation/statistics & numerical data , Ultrasonography/methods
8.
Acta Chir Orthop Traumatol Cech ; 85(6): 392-397, 2018.
Article in Czech | MEDLINE | ID: mdl-37723821

ABSTRACT

PURPOSE OF THE STUDY Evaluation of efficiency and safety in surgically treated patients with Scheuermann hyperkyphosis using posterior-only surgical approach. MATERIAL AND METHODS Our study retrospectively evaluates the results of surgical correction in group of 20 patients with Scheuermann's hyperkyphosis, with an average age of 13 years and 8 month and with follow-up 4 years and 5 month. We evaluated changes of thoracic kyphosis as well as lumbar lordosis in correlation with surgical correction. Furthermore we compared ability of kyphosis to be corrected while performing reclination X-rays befroe surgery in comparation with rate of surgical correction. RESULTS The average correction of thoracic kyphosis was 52% - from preoperative 92° to postoperative 44°. We observed of 36% improvement of correction while surgically corrected in comparision with preoperative recklination X-ray pictures. Secondary correction of lumbar lordosis was from preoperative 84° to posoperative 55°. DISCUSSION Conservative treatment of hyperkyphosis offers only limited treatment results. Combined surgical approach with anterior release and posterior stabilization increase risk of anterior approach and secondary decreasing of lung capacity. Posterior vertberal osteotomies allows quality release and preparation for consecutive correction. Transpedicular instrumentation makes possible segmental correction of kyphotic spine using compression method. CONCLUSIONS Posterior-only surgical approach in combination with vertebral osteotomies allow efective and safe correction of hyperkyhosis in Scheuermann disease. Key words: Scheuermann, hyperkyphosis, transpedicular screws, osteotomy, posterior approach.

9.
Acta Chir Orthop Traumatol Cech ; 83(5): 327-331, 2016.
Article in Czech | MEDLINE | ID: mdl-28102807

ABSTRACT

PURPOSE OF THE STUDY Scapholunate dissociation is a clinically most frequently diagnosed form of carpal instability. The aim of this study was to compare high resolution MRI using a microscopic coil with direct MRI arthrography in patients with suspected scapholunate ligament lesions and compare the results with arthroscopy findings and Geissler's arthroscopy classification. MATERIAL AND METHODS A prospective study was carried out in 47 patients (average age, 30.7 years) with clinical symptoms of wrist instability from 2013 to 2014. The patients were examined with the MR device Philips Achieva 1.5T using a microscopic coil and subsequently by direct MR arthrography. The results of examination were evaluated independently by two groups of physicians using a modified arthroscopic classification. The results were verified arthroscopically. For evaluation, an adjusted Geissler's classification was used. The study was approved by the Multicentre Ethics Committee of the Faculty of Medicine in Brno and informed consent was obtained from each patient. RESULTS A total of The MRI examination was evaluated and included in the study in 44 patients (three were excluded for the presence of motion artefacts). Only 20 patients underwent arthroscopy. Examination with a microscopic coil correctly classified 14 of them; an accuracy of 70 % (95 % CI: 45.7 % - 88.1 %) and p = 0.021. Direct MR arthrography correctly classified 16 of 20 injured ligaments, i.e., an accuracy of 80 % (95 % CI: 56.3 % - 94.3 %) and p = 0.002. DISCUSSION Currently, the diagnosis of pathological changes in the wrist is made by routine MRI especially when there is the possibility of using sequences with high spatial resolution. Even though we achieved poorer results by native examination using these techniques, when they were compared with the results of direct MR arthrography, they were still better than those reported in the recent literature. CONCLUSION The optimal method for an examination algorithm of scapholunate ligament lesions is direct MR arthrography. In our study correct findings of direct MR arthrography using Geissler's classification were shown in 80 % of the patients. Key words: scapholunate ligament, scapholunate ligament lesion, direct MR arthrography, microscopic coil, Geissler's classification.


Subject(s)
Arthrography/methods , Arthroscopy/methods , Magnetic Resonance Imaging/instrumentation , Wrist Injuries/diagnosis , Adult , Arthroscopy/statistics & numerical data , Female , Humans , Male , Middle Aged , Prospective Studies , Sensitivity and Specificity , Wrist Injuries/diagnostic imaging , Wrist Injuries/surgery
10.
Rozhl Chir ; 93(2): 82-6, 2014 Feb.
Article in Czech | MEDLINE | ID: mdl-24702292

ABSTRACT

Idiopathic intracranial hypertension is a disorder that results from an increase of intracranial pressure with unknown cause. A single measurement of intracranial pressure only provides data at one given point in time. Therefore, telemetric monitoring of intracranial pressure was performed in a patient with fluctuating headache and significantly impaired vision, which together accounted for 226.2 hours of recording during normal daily activities. Elevated intracranial pressure was not found during monitoring, so we did not indicate the patient for shunt surgery.


Subject(s)
Intracranial Pressure/physiology , Pseudotumor Cerebri/diagnosis , Pseudotumor Cerebri/physiopathology , Telemetry/instrumentation , Telemetry/methods , Female , Humans , Middle Aged , Tomography, X-Ray Computed
11.
Vnitr Lek ; 59(11): 1022-6, 2013 Nov.
Article in Czech | MEDLINE | ID: mdl-24279448

ABSTRACT

The first reports found in professional literature on the use of bisphosphonates as a treatment date back to 1972. We found the first report on the use of a bisphosphonate comprising nitrogen in its molecule in a publication from 1990. Some of the adverse effects of the particular types of bisphosphonates were described in the registration studies. At least two serious adverse effects of this group of medicines had not been described until 2000. We found the first description of jaw osteonecrosis in relation to the longterm application of bisphosphonates in a publication from 2002 and we found the first description of an atypical bone fracture originating without a corresponding traumatic event in a location with no presence of an osteolytic focus in an article from 2006. These so  called atypical fractures, which are also called fractures without a corresponding traumatic event (low energy fractures), have been described to have occurred in femurs, in the pelvis and less frequently in the metatarsal area. "Atypical fractures" are linked to longterm administration of bisphosphonates, which significantly increases the bone density and impedes osteolysis but it simultaneously increases the fragility of bones and decreases their flexibility. The definition of an atypical fracture of the skeleton emphasises the fact that such fractures occur with an inadequately minimal force (energy) in the aforementioned predilection locations. In the following text we are describing a patient who has been treated for a multiple myeloma with an atypical fracture of the Metatarsal bone 2. This fracture occurred during a regular walk without any excessive load and the patient could not recall any corresponding injury or longer walking. The patient had been administered bisphosphonates for 34 months before the atypical metatarsal fracture occurred. The metatarsal bone fracture was treated through a nonweight  bearing regime for the sole and the pain diminished within a single month. In comparison with the published data of atypical fractures, our case concerns a short interval between initiation of the bisphosphonate administration and the occurrence of the atypical fracture. In the available literature these fractures are described after more than a five year application of a bisphosphonate. New pain in the bearing skeleton in patients treated with bisphosphonates are therefore always subject to an imaging examination among others to exclude an atypical fracture due to an increased fragility of the bone.


Subject(s)
Diphosphonates/adverse effects , Diphosphonates/therapeutic use , Fractures, Spontaneous/chemically induced , Metatarsal Bones/injuries , Multiple Myeloma/drug therapy , Bone Density Conservation Agents , Fractures, Spontaneous/diagnostic imaging , Humans , Long-Term Care , Male , Metatarsal Bones/diagnostic imaging , Middle Aged , Radiography
12.
Klin Onkol ; 26(2): 124-34, 2013.
Article in Czech | MEDLINE | ID: mdl-23718671

ABSTRACT

BACKGROUND: Castleman disease is a non-clonal lymphoproliferative disorder with 2 clinical (unicentric, multicentric) and 4 histomorphological (hyaline vascular, plasma cell, mixed, plasmablastic) forms which combine creating a pleomorphic picture of this rare entity. In our work, the largest documented cohort in the Czech Republic was analyzed focusing on diagnostics and particularly on therapy. PATIENTS AND METHODS: The retrospective study (1998-2013) included 10 patients, 6 males, 4 females. Patients with unicentric form (3) underwent surgical sanitation. Patients with multicentric form (7) were followed-up only (2) or extirpation of the largest mass was carried out (1) or a systemic therapy was administered (4) which comprised the following regimens: R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone), CTD/CAD/CVD (cyclophosphamide, thalidomide/adriamycin/bortezomib, dexamethasone), further including monotherapies with tocilizumab, thalidomide and lenalidomide and in one case (associated POEMS syndrome, i.e. polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) autologous stem cell transplantation after melphalan conditioning was performed. During treatment response monitoring, all patients underwent PET/CT examination (fluorodeoxyglucose positron emission tomography/computed tomography). RESULTS: The remission rate was 50% (3 unicentric forms with remission lasting 51, 8 and 9 months, resp.; 2 multicentric forms with remission lasting 3 months during thalidomide therapy and 12 months after lenalidomide therapy), stable disease was observed in 40% of cases (multicentric forms, 2 without any treatment followed-up for 171 and 24 months, resp.; 1 after systemic therapy followed-up for 23 months; 1 after two extirpations with stable lymphadenopathy for 15 years, where the first operation was 27 years ago). In one patient (10%), the associated POEMS syndrome progressed rapidly with fatal consequences (4 months follow-up). CONCLUSION: Unlike unicentric forms completely curable by excision, multicentric forms are often treatment-refractory. Concerning high cost-effectiveness, good tolerability and documented efficacy also in rituximab-resistant cases, we prefer immunomodulatory drugs (particularly thalidomide) for managing multicentric Castleman disease in our center.


Subject(s)
Castleman Disease/drug therapy , Castleman Disease/pathology , Adult , Aged , Female , Humans , Male , Middle Aged
13.
Acta Chir Orthop Traumatol Cech ; 75(3): 167-72, 2008 Jun.
Article in Czech | MEDLINE | ID: mdl-18601813

ABSTRACT

PURPOSE OF THE STUDY: To define the role of ultrasonography in the diagnostic algorithm for patients with shoulder joint injury and to show its potential for the detection of rotator cuff tears and Hill-Sachs lesions. MATERIAL AND METHODS: A group of 52 patients with clinical signs of shoulder disorders following trauma who were treated in the 2005-2006 period. After ultrasonographic examination, all patients were surgically treated by arthroscopy. In 12 of them an additional magnetic resonance imaging was carried out before surgery. The results of ultrasonography were compared with arthroscopic findings in terms of detection of full-thickness rotator cuff tears and Hill-Sachs lesions. These were the two most frequent traumatic lesions detected by ultrasonography. RESULTS: A full-thickness tear of the rotator cuff was correctly diagnosed in 13 patients. In further four the ultrasound finding was incorrectly interpreted as a moderate rotator cuff injury. For the detection of full-thickness tears, the sensitivity of the method was 76 %, its specificity was 94 % and accuracy 88 %. The detection of Hill-Sachs lesions by ultrasonography correlated with arthroscopic findings, with a sensitivity of 86 %, specificity of 93 % and accuracy of 92 %. DISCUSSION: A number of studies report on options for the ultrasonographic detection of various types of traumatic injury to shoulder structures. Examination by ultrasound shows skeletal surfaces, thus permitting detection of a minor bone injury or a Hill- Sachs defect, and reveals soft tissue shoulder structures including tendons, ligaments and bursae. In some studies the possibility of detecting rotator cuff tears by ultrasonography has been described. Although sufficient accuracy of ultrasonographic examination in this region is reported, the results are not consistent. CONCLUSIONS: Our results show high reliability of ultrasonography for the diagnosis of shoulder trauma. The detection of full-thickness rotator cuff tears and Hill-Sachs lesions was possible with sufficient accuracy, which makes this quick, simple and available examination a valuable diagnostic tool. The finding of a rotator cuff tear is important information for the orthopaedist and, in the majority of patients, is also an indication for surgery. An ultrasonographic examination can therefore be regarded as a standard part of the diagnostic algorithm for shoulder trauma.


Subject(s)
Shoulder Injuries , Shoulder Joint/diagnostic imaging , Arthroscopy , Humans , Rotator Cuff Injuries , Rupture , Sensitivity and Specificity , Shoulder Joint/surgery , Ultrasonography
14.
Childs Nerv Syst ; 24(11): 1361-9, 2008 Nov.
Article in English | MEDLINE | ID: mdl-18516608

ABSTRACT

BACKGROUND: Central neurocytoma (CN) represents a rare, relatively recently described primary central nervous system tumor. It ranks among intraventricular tumors due to its predominant location within the lateral brain ventricles. CN occurs mostly in young adults around the 3rd decade of life; almost a fifth of the cases are children under 18 years of age. OBJECTIVES: The authors present three cases of patients with histopathologically confirmed CN, emphasizing diagnostic imaging issues. A review of the literature concerning differential diagnosis and clinical and therapeutic aspects is also presented. CONCLUSION: Literature reports of CN comprise most likely case reports, small cohorts of patients, and meta-analytic studies due to the generally low incidence of this tumor. In the current paper, the authors summarize up-to-date knowledge of this rare disease on the background of their own observations. CN should be included in the list for differential diagnostics of intraventricular brain tumors, especially those located in lateral ventricles.


Subject(s)
Cerebral Ventricle Neoplasms/diagnostic imaging , Neurocytoma/diagnostic imaging , Adolescent , Adult , Cerebral Ventricle Neoplasms/pathology , Cerebral Ventricle Neoplasms/therapy , Combined Modality Therapy , Diagnosis, Differential , Female , Humans , Magnetic Resonance Imaging , Male , Neurocytoma/pathology , Neurocytoma/therapy , Neurosurgical Procedures , Radiotherapy , Tomography, X-Ray Computed
15.
Acta Chir Orthop Traumatol Cech ; 75(2): 117-22, 2008 Apr.
Article in Czech | MEDLINE | ID: mdl-18454916

ABSTRACT

PURPOSE OF THE STUDY: To evaluate the efficacy of surgical treatment in pelvic deformities associated with neuromuscular spine deformity, using radiographic parameters and clinical outcome analysis. In the lumbo-pelvic region, spinal deformity is most frequently combined with pelvic obliquity, lumbar hyperlordosis, hip deformity and leg-length discrepancy. Pelvic deformities include an excessive posterior or anterior pelvic tilt, obliquity or rotation and windblown hip syndrome. MATERIAL AND METHODS: In the period from 1994 to 2006, 42 paediatric patients (28 girls and 14 boys) underwent surgical correction of spine and pelvic deformities by the Luque-Galveston technique. The group included 25 patients with an underlying diagnosis of a spastic form of cerebral palsy, seven patients affected by paralysis, six with Duchenne muscular dystrophy and four with spinal muscular atrophy. The average age at the time of surgery was 14 years and 3 months and the patients were followed- up for 7 years and 5 months on the average. The results were evaluated on the basis of findings on antero-posterior and lateral radiographs including the pelvis, hip joints and the whole spine. The patients were examined before surgery, then immediately after it, and at yearly follow-up intervals. RESULTS: The mean pre-operative pelvic obliquity was 37 degrees (+/-6.0) and it improved to 9 degrees (+/-4.5) post-operatively. Horizontalization of the sacrum was corrected from the mean preoperative value of 19 degrees (+/-5.0) to 37 degrees (+/-6.1) post operatively. This difference was statistically significant (p=0.001). Scoliosis curve correction achieved by the surgery was from 79 degrees (+/-21.3) pre-operatively to 35 degrees (+/-14.5) post-operatively, with a mean correction rate of 56 %. The following complications were recorded: faulty insertion of the pelvic fixation resulting in perforation of the medial cortical substance of the iliac crest in one patient, pseudoarthrosis in the region of thoraco-lumbal junction in two patients, instrumentation failure with the need of pseudoarthrosis resection and re-instrumentation in one patient, and deep infection requiring wound irrigation and longterm antibiotic therapy. DISCUSSION: The surgical correction of pelvic deformity is always associated with operative treatment of scoliosis. However, the procedure is regularly preceded by surgical correction of muscular imbalance of the lower limbs and pelvis and of hip deformities. The surgical stabilization of spinal and pelvic deformities brings about the loss of some alternative motor stereotypes. This disadvantage is compensated for by a better sitting stability and better prospects for prosthetic care. CONCLUSIONS: The radiographic and clinical findings in the patients treated showed good correction of pelvic deformities in the frontal and sagittal planes. Pelvic obliquity correction thus contributes to the improvement of sitting stability in physically disabled patients.


Subject(s)
Neuromuscular Diseases/complications , Pelvic Bones/pathology , Scoliosis/surgery , Spinal Fusion/methods , Adolescent , Child , Female , Humans , Male , Scoliosis/etiology , Scoliosis/pathology
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