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Total synthesis of (+/-)-elegansidiol, (+/-)-farnesiferol B, and (+/-)-farnesiferol D.
Yadav, Jhillu Singh; Satyanarayana, Kamani; Sreedhar, Pamu; Srihari, Pabbaraja; Shaik, Thokhir Basha; Kalivendi, Shasi Vardhan.
Bioorg Med Chem Lett ; 20(12): 3814-7, 2010 Jun 15.
Article in English | MEDLINE | ID: mdl-20529689

ABSTRACT

The racemic total synthesis of elegansidiol, farnesiferol B, and farnesiferol D has been obtained following a Diels-Alder approach. Gillman addition, cross metathesis reaction are the other key steps involved in the target synthesis.


Subject(s)
Biological Products/chemical synthesis , Sesquiterpenes/chemical synthesis , Terpenes/chemical synthesis , Biological Products/pharmacology , Cell Line, Tumor , Cell Proliferation/drug effects , Drug Evaluation, Preclinical/methods , Humans , Lung Neoplasms/pathology , Neuroblastoma/pathology , Stereoisomerism , Terpenes/pharmacology
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