A selective analysis of sulfamethoxazole - Trimethoprim in tablet formulations using graphene oxide-zinc oxide quantum dots based nanocomposite modified glassy carbon electrode.

In this study, simultaneous analysis on electrochemical detection of SMX and TMP in tablet formulation has been made using graphene oxide (GO) and ZnO QDs (GO-ZnO QDs) based nanocomposite modified glassy carbon electrode (GCE). The functional group presence was observed using FTIR study. The electrochemical characterization for GO, ZnO QDs and GO-ZnO QDs was studied using cyclic voltammetry using [Fe(CN)6]3- medium. In order to estimate the electrochemical redox behavior of SMX and TMP from tablet, the developed electrodes GO/GCE, ZnO QDs/GCE and GO-ZnO QDs/GCE are initially tested for electrochemical activity towards the SMX tablet in BR pH 7 medium. Later their electrochemical sensing has been monitored using square wave voltammetry (SWV). On observing the characteristic behavior of developed electrodes, GO/GCE exhibited detection potential of +0.48 V for SMX and +1.37 V for TMP whereas, ZnO QDs/GCE with +0.78V for SMX and for TMP 1.01 V respectively. Similarly, for GO-ZnO QDs/GCE, its 0.45 V for SMX and 1.11 V for TMP are observed using cyclic voltammetry. The obtained potential results on detecting SMX and TMP are in good agreement with previous results. Under optimized conditions, the response has been monitored with linear concentration range 50 µg/L to 300 µg/L for GO/GCE, ZnO QDs/GCE and GO-ZnO QDs/GCE in SMX tablet formulations. Their detection limits for the individual detection using GO-ZnO/GCE for SMX and TMP are found to be 0.252 ng/L and 19.10 µg/L and for GO/GCE it was 0.252 pg/L and 2.059 ng/L respectively. It was observed that ZnO QDs/GCE could not provide the electrochemical sensing towards SMX and TMP which may be due to the ZnO QPs can act as a blocking layer impeding the electron transfer process. Thus, the sensor performance lead to promising biomedical applications in real-time monitoring on evaluating selective analysis with SMX and TMP in tablet formulations.

Development of in-situ electrochemical heavy metal ion sensor using integrated 1D/0D/1D hybrid by MWCNT and CQDs supported MnO2 nanomaterial.

An integrated 1D/0D/1D hybrid nanomaterial was prepared from MWCNT supported carbon quantum dots @ MnO2 nanomaterial for a sensitive and selective electrochemical heavy metal ion sensor by hydrothermal methods. The developed nanomaterials were characterized by various analytical methods such as FESEM, HRTEM, XRD, FTIR, EDX and elemental mapping study, and also its electrochemical properties of the prepared samples were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) analysis. Differential pulse voltammetry (DPV) analysis has been used to investigate the quantitative detection of heavy metal ions such as cadmium and chromium on modified electrodes under optimal conditions. The in-situ electrochemical sensitivity and selectivity of the samples were determined by varying various parameters, such as the concentration of heavy metal ions, different electrolytes and electrolyte pH. The observed DPV results show that prepared MWCNT (0.05 wt%) and CQD (0.1 wt%) supported MnO2 nanoparticles show effective detection response for chromium (IV) metal ion. In particular, 0D CQD, 1D MWCNT, and MnO2 hybrid nanostructures produced a synergistic effect among them, resulting in strong electrochemical performance of the prepared samples against the target metal ions.

GO/ZnO nanocomposite - as transducer platform for electrochemical sensing towards environmental applications.

Graphene Oxide-Zinc Oxide (GO-ZnO) - a new nanomaterial that has queued the interest of researchers. Their intriguing promising physical and electrochemical features of electrode material have led to its widespread use in electrochemical sensor applications. GO-ZnO based nanomaterial were extensively exploited in the construction of electrochemical sensors due to their adaptability and distinct qualities. On understanding the structural role of these materials, their modification processes are critical for realizing their full potential. The advancement of technology on new concepts and strategies has revolutionized the field of sensor devices with high sensitivities and selectivity. These tools can test a range of contaminants quickly, accurately, and affordably while performing automated chemical analysis in complicated matrices. This paper highlights the electrochemical transducer surface for sensing various analytes and current research activity on GO-ZnO nanocomposite. Additionally, we talked about current developments in GO-ZnO nanostructured composites to identify relevant analytes (i.e., Nitrophenols, Antibiotic Drugs, Biomolecules). While being used in the laboratory, the majority of produced systems have proven to bring about excellent gains. Their monitoring application still has a long way to go before it is fixed due to problems like technological advancements and multifunctional strategies to get around the challenges for improving the sensing systems.

Investigation of Nafion coated GO-ZnO nanocomposite behaviour for sulfamethoxazole detection using cyclic voltammetry.

The electrochemical behavior of sulfamethoxazole (SMX) was investigated on the surface of the glassy carbon electrode with Nafion coated GO, ZnO, GO-ZnO nanocomposites using cyclic voltammetry (CV). The results of voltammetric studies exhibited a considerable increase in background current on SMX detection at nafion coated GO-ZnO nanocomposite GC electrodes. However, the adopted fabrication procedure for GC electrodes was reported previously but only difference is nafion was drop casted over the fabricated nanocomposite electrode. In order to investigate the electrochemical performance behavior of GO/GCE, ZnO/GCE, GO-ZnO/GCE, variation on ZnO amounts with Nafion coated and uncoated GO/GC electrodes were involved and it was analyzed using cyclic voltammetry in 5 mM K2FeCN6 using 0.1 M KCl solution electrolyte medium. In GO-ZnO/GC electrode, peak currents got reduced when compared with GO/GC electrode but their potential voltage difference (peak-to-peak) separation was increased. Similar results was observed for nafion coated GO-ZnO/GC electrode. On comparing the electrochemical process, the importance of nafion coated GO-ZnO nanocomposites were studied and proceeded with optimized amounts of modifier on the electrode surface for SMX detection. Thus Nf/GO-ZnO with different ZnO ratios performance showed significant response on determining SMX, resulting to progress as electrode sensor for health-care applications.

Static and dynamic analysis of sulfamethoxazole using GO/ZnO modified glassy carbon electrode by differential pulse voltammetry and amperometry techniques.

Surface water contamination of sulfamethoxazole (SMX) has tremendously affected the ecosystem. A primary study was performed to develop an electrochemical sensor for the determination of SMX. Overcoming the demerit associated with the conventional techniques, an electrochemical method was developed using GO/ZnO nanocomposite modified electrode to detect SMX in 0.1 M phosphate buffer (pH-5.5) buffer solution. The GO, ZnO and GO/ZnO nanocomposite were prepared using modified Hummer's, precipitation and sonochemical methods, respectively. Physico-chemical properties of all the materials and its modified electrode were analysed. Comparison was made by studying the SMX sensing performance of electrodes modified with GO, ZnO and GO/ZnO nanocomposites. Out of which GO/ZnO nanocomposite exhibited excellent sensing performance with the concentration range from 0.10 × 10-6 to 1.5 × 10-6 M with the limit of detection (LOD) 28.9 nM. The parameters such as electrolyte, effect of pH, scan rate were optimized for effective sensing performance. From the optimized results 0.1 M phosphate buffer was found to be a suitable electrolyte and the pH 5.5 was found to be appropriate to sense SMX at the scan rate 50 mVs-1. Under optimized condition, the Differential Pulse Voltammetry (DPV) and Amperometry techniques were adopted for electrochemical sensing of SMX under static and hydrodynamic condition. The developed method was successfully tested for real time analysis for the samples collected from waste water treatment plant.

A recent advancement on nanomaterials for electrochemical sensing of sulfamethaoxole and its futuristic approach.

Sulfamethoxazole (SMX) forms the high harmfulness and causing negative health impacts to well-being human and environment that found to be major drastic concern. It is subsequently important to keep in track for monitoring of SMX through convenient detecting devices which include the requirement of being minimal expense and potential for on location environmental applications. Nanomaterials based design has been proposed to determine the SMX antibiotic which in turn provides the solution for this issue. In spite of the critical advancement accomplished in research, further endeavors are yet to foster the progress on electrochemical sensors with the guide of various functional nanomaterials and guarantee the effective transportability for such sensors with improved coherence. Moreover, it has been noticed that, only few reports on electrochemical sensing of SMX detection using nanomaterials was observed. Hence an in-depth evaluation of electrochemical sensing systems using various nanomaterials for SMX detection was summarized in this review. Additionally this current review centers with brief presentation around SMX hazard evaluation followed by study on the current logical techniques to feature the importance for SMX detection. This review will provide the sum up view towards the future ideas of this field which assists in improving the detecting strategies for SMX detection.

Facile hydrothermal bio-synthesis of cellulose acetate templated CuS nanorods like fibres: antibacterial, cytotoxicity effects and DNA cleavage properties against A549 lung cancer cells.

In this research, the hydrothermal method was used for synthesising cellulose acetate (CA) templated nanorods like CuS fibres using vegetable extract (Brassica oleracea var. italica). These extracts act as a reducing agent in the presence of CA. Surprisingly, when the same reaction was carried out in the absence of CA and broccoli extract, structural morphology disappeared and was found as agglomerated. In the presence of cellulose templated extract mediated CuS has revealed as nanorods like fibres and was confirmed by field emission scanning electron microscope analysis. Their crystallinity property of CuS nanoparticles (NPs) and cellulose templated biosynthesised CuS NPs was analysed and compared using X-ray diffraction technique. The biological activities of the obtained product were examined for antibacterial assessment against two bacterial strains that include two-gram negative strains (E.Coli and S. aureus). The nanostructured product found to exhibit excellent antibacterial agent against all the strains. Biosynthesised nanostructure showed its efficacy against A549 lung cancer cells which might attribute to a larger surface to volume ratio of nanorods like fibres. The authors observation suggest that CuS nanorods like fibres can significantly reduce the cell growth with IC50 value of 31.2 µg/ml.