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J Antibiot (Tokyo) ; 67(10): 697-701, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24824817

ABSTRACT

A novel depsipeptide (PM181110) was purified from an endophytic fungus Phomopsis glabrae isolated from the leaves of Pongamia pinnata (family Fabaceae). The chemical structure of PM181110 was elucidated using physiochemical properties, 2D NMR and other spectroscopic methods. PM181110 is very close in structure to FE399. The compound exhibited in vitro anticancer activity against 40 human cancer cell lines with a mean IC50 value of 0.089 µM and ex vivo efficacy towards 24 human tumor xenografts (mean IC50=0.245 µM).


Subject(s)
Antineoplastic Agents/pharmacology , Ascomycota/chemistry , Biological Products/pharmacology , Depsipeptides/pharmacology , Endophytes/chemistry , Antineoplastic Agents/chemistry , Antineoplastic Agents/isolation & purification , Ascomycota/isolation & purification , Biological Products/chemistry , Biological Products/isolation & purification , Cell Line, Tumor , Chemical Phenomena , Depsipeptides/chemistry , Depsipeptides/isolation & purification , Endophytes/isolation & purification , Humans , Inhibitory Concentration 50 , Millettia/microbiology , Molecular Structure , Plant Leaves/microbiology , Spectrum Analysis
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